Clinical evaluation of a radioimmunoprecipitation assay for IA-2 antibody and comparison of GAD antibody in type 1 diabetes mellitus

Autoimmunity

Volumn 32, Issue 2, 2000, Pages 79-88

  Ohta, Mitsuhiro ^a,b   Ohta, Kiyoe ^a   Obayashi, Hiroshi ^c   Nakamura, Naoto ^d   Shigeta, Hirofumi ^d   Nakano, Koji ^d   Hasegawa, Goji ^d   Fukui, Michiaki ^d   Kitagawa, Yoshihiro ^d   Nishimura, Masataka ^a   Itoh, Nobuyuki ^e  

^a UTANO NATIONAL HOSPITAL   (Japan)

^b KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^c Kyoto Microbiological Institute   (Japan)

^d KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^e KYOTO UNIVERSITY   (Japan)

Author keywords

Autoantibody; Diabetes Mellitus (DM); GAD antibody; IA 2 antibody; RIA; Type 1 DM; Type 2 DM

Indexed keywords

AUTOANTIBODY; ENZYME ANTIBODY; GLUTAMATE DECARBOXYLASE; INSULIN ANTIBODY; PANCREAS ISLET CELL ANTIBODY; RECOMBINANT HUMAN INSULIN;

ADULT; AGED; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; JAPAN; MAJOR CLINICAL STUDY; MASS SCREENING; NON INSULIN DEPENDENT DIABETES MELLITUS; PREVALENCE; RADIOIMMUNOPRECIPITATION; RISK ASSESSMENT;

EID: 0033776247     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916930008994076     Document Type: Article

References (26)

1. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
2. Detection of decarboxylase
3. Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases
4. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma
5. Relationship of the 37,000 and 40,000 Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2(ICA512)
6. Protein tyrosine phosphatase-like proteins: Link with IDDM
7. The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2
8. Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies
9. Assessment of precision of concordance, specificity and sensitivity of islet cell antibody measurement in 41 assays
10. Analysis of islet cell antibodies in frozen sections of human pancreas
11. Precision of the islet-cell antibody assay depends on the pancreas
12. Radioimmunoprecipitation assay for glutamic acid decarboxylase antibodies evaluated clinically with sera from patients with insulin-dependent diabetes mellitus
13. Identification of protein tyrosine phosphatase-like IA-2 (islet cell antigen 512) as the insulin-dependent diabetes-related 37/40K autoantigen and a target of islet-cell antibodies
14. Autoantibodies to IA-2 in insulin-dependent diabetes mellitus measurement with a new immunoprecipitation assay
15. The preparation of 131I-labelled human growth hormone of high specific radioactivity
16. IA-2, transmembrane protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus
17. Autoantibodies [17] associated with Type 1 diabetes mellitus persist after diagnosis in children
18. Comparison of GAD and ICA512/IA-2 antibodies at and after the onset of IDDM
19. GAD antibodies are associated with thyroid antibodies in children with IDDM and in their siblings
20. IA-2 antibodies - A sensitive marker of IDDM with clinical onset in childhood and adolescence
21. Diagnostic significance of antibodies to glutamic acid decarboxylase in Japanese diabetic patients with secondary oral hypoglycemic agents failure
22. Pancreatic islet cell cytoplasmic antibody in diabetes is represented by antibodies to islet cell antigen 512 and glutamic acid decarboxylase
23. Ten year follow up study of islet cell antibodies and childhood diabetes mellitus
24. Combined analysis and single-step detection of GAD65 and IA-2 autoantibodies in IDDM can replace the histochemical islet cell antibody test
25. Combind screening for autoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first degree relatives of patients with IDDM
26. A simple solid-phase radioimmunoassay for glutamic acid decarboxylase (GAD) antibodies in patients with diabetes mellitus