Pathogenesis of fibrosis produced by asbestos and man-made mineral fibers: What makes a fiber fibrogenic?

Inhalation Toxicology

Volumn 12, Issue SUPPL. 3, 2000, Pages 15-26

  Churg, A ^a   Wright, J ^a   Gilks, B ^a   Dai, J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033771281     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/08958378.2000.11463227     Document Type: Conference Paper

References (28)

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2. Response of mouse lung to crocidolite asbestos. II. Pulmonary fibrosis after long fibres
3. Silica deposition in the lung during epithelial injury potentiates fibrosis and increases particle translocation to lymph nodes
4. Reduced tumor necrosis factor-α and transforming growth factor-β expression in the lungs of inbred mice that fail to develop fibroproliferative lesions consequent to asbestos exposure
5. Analyzing the genes and peptide growth factors expressed in lung cells in vivo consequent to asbestos exposure and in vitro
6. Free radical activity of synthetic vitreous fibers: Iron chelation inhibits hydroxyl radical generation by refractory ceramic fiber
7. The uptake of mineral particles by pulmonary epithelial cells
8. Cigarette smoke increases amosite asbestos fiber binding to the surface of tracheal epithelial cells via a surface iron dependent mechanism
9. Mineral dusts directly induce epithelial and interstitial fibrogenic mediators and matrix components in the airway wall
10. Asbestos fibre length-dependent detachment injury to alveolar epithelial cells in vitro: Role of a fibronectin binding receptor
11. α-Quartz induced chemokine expression by rat lung epithelial cells
12. Crocidolite activates NF-κB and MIP-2 gene expression in rat alveolar epithelial cells. Role of mitochondrial-derived oxidants
13. Role of iron in the reactivity of mineral fibers
14. Free radical activity of industrial fibers: Role of iron in oxidative stress and activation of transcription factors
15. Iron in asbestos chemistry and carcinogenicity
16. Chronic inhalation study of fiber glass and amosite asbestos in hamsters
17. The importance of fiber biopersistence and lung dose in determining the chronic inhalation effects of X607, RCF1, and chrysotile asbestos in rats
18. Acute biological effects of intratracheally instilled titanium dioxide whisker compared with nonfibrous titanium dioxide and amosite in rats
19. Induction of c-fos and c-jun proto-oncogenes in target cells of the lung and pleura by carcinogenic fibers
20. Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor (NF)-κB
21. Asbestosis: Clinical spectrum and pathogenic mechanisms
22. TNF-α receptor knockout mice are protected from the fibroproliferative effects of inhaled asbestos fibers
23. Mechanisms in the pathogenesis of asbestosis and silicosis
24. Determination of carcinogenic potential of mineral fibers by 8-hydroxydeoxyguanosine as a marker of oxidative DNA damage in mammalian cells
25. Patterns of inflammation, cell proliferation, and related gene expression in lung after inhalation of chrysotile asbestos
26. Cellular and molecular mechanisms of asbestos-induced fibrosis
27. Effects of mineral fibers on the expression of genes whose product may play a role in fiber pathogenesis
28. Critical role of glass fiber length in TNF-α production and transcription factor activation in marophages