Marrow transplantation and targeted gene therapy to the skeleton

Clinical Orthopaedics and Related Research

Volumn 379, Issue SUPPL., 2000, Pages

  Lian, J B ^a   Stein, G S ^a   Steins, J L ^a   Van Wijnen, A J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

BONE DEVELOPMENT; BONE DISEASE; BONE MARROW TRANSPLANTATION; BONE METASTASIS; CARTILAGE CELL; CELL SPECIFICITY; CHONDROGENESIS; CHONDROPATHY; CONFERENCE PAPER; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE TARGETING; GENE THERAPY; HEMATOPOIESIS; HUMAN; MESENCHYME CELL; NONHUMAN; OSTEOBLAST; PHENOTYPE; PRIORITY JOURNAL; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSGENE;

EID: 0033771098     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1097/00003086-200010001-00019     Document Type: Conference Paper

References (67)

1. AP-1 and vitamin D receptor (VDR) signaling pathways converge at the rat osteocalcin VDR element: Requirement for the internal activating protein-1 site for vitamin D-mediated trans-activation
2. Contributions of distal and proximal promoter elements to glucocorticoid regulation of osteocalcin gene transcription
3. Osteoblast-specific expression of growth hormone stimulates bone growth in transgenic mice
4. Targeted expression of calcitonin gene-related peptide to osteoblasts increases bone density in mice
5. Runt homology domain proteins in osteoblast differentiation: AML-3/CBFA 1 is a major component of a bone specific complex
6. Transforming growth factor-beta 1 responsiveness of the rat osteocalcin gene is mediated by an activator protein- 1 binding site
7. Association of nuclear matrix antigens with exon-containing splicing complexes
8. A three-dimensional view of precursor messenger RNA metabolism within the mammalian nucleus
9. Ribonucleic acid precursors are associated with the chick oviduct nuclear matrix
10. The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression
11. A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition
12. Bone marrow stromal cells as a vehicle for gene transfer
13. Osf2/Cbfal: A transcriptional activator of osteoblast differentiation
14. Sequence-specific DNA-binding proteins are components of a nuclear matrix-attachment site
15. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein
16. Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype
17. Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass
18. Activity of the osteocalcin promoter in skeletal sites of transgenic mice and during osteoblast differentiation in bone marrow-derived stromal cell cultures: Effects of age and sex
19. Modified intranuclear organization of regulatory factors in human acute leukemias: Reversal after treatment
20. YY1 regulates VDR/RXR mediated transactivation of the vitamin D responsive osteocalcin gene
21. Histone acetyltransferase is associated with the nuclear matrix
22. Bone tissue-specific transcription of the osteocalcin gene: Role of an activator osteoblast-specific complex and suppressor hox proteins that bind the OC box
23. Transcriptional control of the tissue-specific, developmentally regulated osteocalcin gene requires a binding motif for the Msx family of homeodomain proteins
24. Osteoblast-specific gene expression after transplantation of marrow cells: Implications for skeletal gene therapy
25. Energy-dependent chromatin remodelers: Complex complexes and their components
26. Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D responsive transcription and contribute to chromatin organization
27. Collagenase 3 is a target of Cbfal, a transcription factor of the runt gene family involved in bone formation
28. Dimer formation by an N-terminal coiled coil in the APC protein
29. The human osteocalcin promoter directs bone-specific vitamin D-regulatable gene expression in transgenic mice
30. Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models
31. Targeted disruption of Cbfal results in a complete lack of bone formation owing to maturational arrest of osteoblasts
32. Intranuclear targeting of DNA replication factors
33. Association of chromosome territories with the nuclear matrix. Disruption of human chromosome territories correlates with the release of a subset of nuclear matrix proteins
34. The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha 2 transcription factor
35. The tissue-specific nuclear matrix protein, NMP-2, is a member of the CBF/AML/PEBP2/runt domain transcription factor family: Interactions with the osteocalcin gene promoter
36. AML-2 is a potential target for transcriptional regulation by the t(8;21) and t(12;21) fusion proteins in acute leukemia
37. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1
38. Changes in chromatin structure support constitutive and developmentally regulated transcription of the bone-specific osteocalcin gene in osteoblastic cells
39. Mutations involving the transcription factor CBFA 1 cause cleidocranial dysplasia
40. Association of transcription factors with the nuclear matrix
41. Cells capable of bone production engraft from whole bone marrow transplants ininonablated mice
42. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
43. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
44. Subunits of the yeast SWI/SNF complex are members of the actin-related protein (ARP) family
45. Mutation analysis of core binding factor A 1 in patients with cleidocranial dysplasia
46. Multiple copies of the bone-specific osteocalcin gene in mouse and rat
47. The localization of the HRX/ALL 1 protein to specific nuclear subdomains is altered by fusion with its eps 15 translocation partner
48. p53 Tumor suppressor gene therapy for cancer
49. The critical role of chromosome translocations in human leukemias
50. Stage-specific expression of D1x-5 during osteoblast differentiation: Involvement in regulation of osteocalcin gene expression
51. Adenovirus terminal protein mediates both nuclear matrix association and efficient transcription of adenovirus DNA
52. Multiple levels of steroid hormone-dependent control of osteocalcin during osteoblast differentiation: Glucocorticoid regulation of basal and vitamin D stimulated gene expression
53. In vivo suppression of osteosarcoma pulmonary metastasis with intravenous osteocalcin promoter-based toxic gene therapy
54. Human and murine osteocalcin gene expression: Conserved tissue restricted expression and divergent responses to 1,25-dihydmxyvitamin D 3 in vivo
55. MLL is fused to CBP a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)
56. Nuclear structure - Gene expression interrelationships: Implications for aberrant gene expression in cancer
57. Crystal structure of the nuclear matrix targeting signal of the transcription factor AML-1/PEBP2αB/CBFα2
58. Msx-2/Hox 8.1: A transcriptional regulator of the rat osteocalcin promoter
59. Nuclear matrix association of multiple sequence-specific DNA binding activities related to SP-1, ATF, CCAAT, C/EBP, OCT-1, and AP- 1
60. Segregation of transcription and replication sites into higher order domains
61. Three-dimensional visualization of transcription sites and their association with splicing factor-rich nuclear speckles
62. Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells
63. Alteration of nucleosome structure as a mechanism of transcriptional regulation
64. Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein
65. Intranuclear targeting of AML/CBFα regulatory factors to nuclear matrix-associated transcriptional domains
66. Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBFα transcription factors