A role for protein kinase C in a form of metaplasticity that regulates the induction of long-term potentiation at CA1 synapses of the adult rat hippocampus

European Journal of Neuroscience

Volumn 12, Issue 11, 2000, Pages 4055-4062

  Bortolotto, Z A ^a   Collingridge, G L ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

LTP; MCPG; Memory; Metabotropic glutamate (mGlu) receptor; PKA; PKC

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; CHELERYTHRINE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN KINASE C;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; HIPPOCAMPUS; LONG TERM POTENTIATION; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SYNAPSE; SYNAPTIC TRANSMISSION; TETANUS;

ALKALOIDS; ANIMALS; BENZOATES; BENZOPHENANTHRIDINES; CYCLIC AMP; ELECTRIC STIMULATION; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GLYCINE; HIPPOCAMPUS; INDOLES; LONG-TERM POTENTIATION; NEURONAL PLASTICITY; PHENANTHRIDINES; PROTEIN KINASE C; RATS; RATS, WISTAR; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPSES; SYNAPTIC TRANSMISSION; THIONUCLEOTIDES;

EID: 0033769172     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.00291.x     Document Type: Article

References (60)

1. Modified hippocampal long-term potentiation in PKC-gamma-mutant mice
2. Metaplasticity: The plasticity of synaptic plasticity
3. Metaplasticity: A new vista across the field of synaptic plasticity
4. A data acquisition program for on-line analysis of long-term potentiation and long-term depression
5. Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation
6. Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors
7. A synaptic model of memory: Long-term potentiation in the hippocampus
8. Involvement of calcium/calmodulin-dependent protein kinases in the setting of a molecular switch involved in hippocampal LTP
9. Actions of a protein kinase C inhibitor on the induction of LTP and the setting the molecular switch in area CA1 of rat hippocampal slices
10. Metabotropic glutamate receptors activate a molecular switch which regulates the induction of long-term potentiation
11. PKC inhibitors block the setting of the molecular switch but not LTP at CA1 synapses
12. Kainate receptors are involved in synaptic plasticity
13. Low frequency activation of the NMDA receptor system can prevent the induction of LTP
14. Facilitation of long-term potentiation by prior activation of metabotropic glutamate receptors
15. Inhibition of protein-kinase-C blocks 2 components of LTP persistence, leaving initial potentiation intact
16. Potent selective inhibitors of protein kinase C
17. Evidence that protein kinase M does not maintain long-term potentiation
18. Effects of cAMP stimulate a late stage of LTP in hippocampal CA1 neurons
19. The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity
20. Lack of an effect of novel inhibitors with high specificity for protein kinase C on the action of the phorbol ester 12-0-tetradecanoyl-phorbol-13-acetate on mouse skin in vivo
21. Inhibition of protein kinase Cμ by various inhibitors. Differentiation from protein kinase C isoenzymes
22. Chelerythrine is a potent and specific inhibitor of protein-kinase-C
23. Bidirectional regulation of protein kinase Mζ in the maintenance of long-term potentiation and long-term depression
24. The influence of prior synaptic activity on the induction of long-term potentiation
25. Specificity of Protein-kinase inhibitor peptides and induction of long-term potentiation
26. Effects of KN-62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, on long-term potentiation in the rat hippocampus
27. Persistent protein-kinase activation in the maintenance phase of long-term potentiation
28. Mechanism of protein-kinase-C activation during the induction and maintenance of long-term potentiation probed using a selective peptide substrate
29. Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans
30. The CaM kinase II hypothesis for the storage of synaptic memory
31. Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism
32. Blockade of long-term potentiation and of NMDA receptors by the protein-kinase-C antagonist calphostin-C
33. Protein-kinase-C inhibitors eliminate hippocampal long-term potentiation
34. Persistent protein kinase activity underlying long-term potentiation
35. Inhibition of postsynaptic PKC or CamKII blocks induction but not expression of LTP
36. Differential effects of protein kinase inhibitors on pre-established long-term potentiation in rat hippocampal neurons in vitro
37. Protein kinase A inhibitors prevent the maintenance of hippocampal long-term potentiation
38. The extended protein kinase C superfamily
39. 2+ - Triggered molecular switch
40. Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are anagonistic in vitro
41. Induction of stable long-term potentiation in the presence of the protein kinase C antagonist staurosporine
42. Protein kinase C and lipid signalling for sustained cellular responses
43. The design and biological properties of potent and selective inhibitors of protein kinase C
44. Tetanically induced LTP involves a similar increase in the AMPA and NMDA receptor components of the excitatory postsynaptic current - Investigations of the involvement of mGlu receptors
45. Protein synthesis-dependent formation of protein kinase M zeta in long-term potentiation
46. Postsynaptic inhibitors of calcium/calmodulin-dependent protein kinase type II block induction but not maintenance of pairing-induced long-term potentiation
47. Potentiated transmission and prevention of further LTP by increased CaMKII activity in postsynaptic hippocampal slice neurons
48. Inhibitors of calmodulin and protein kinase-C block different phases of hippocampal long-term potentiation
49. Polymyxin-B, an inhibitor of protein kinase-C prevents the maintenance of synaptic long-term potentiation in hippocampal CA1 neurons
50. Activation of a K-252b-sensitive protein kinase is necessary for a post-synaptic phase of long-term potentiation is area CA1 of rat hippocampus
51. A Biochemist's view of long-term potentiation
52. Persistent activation of the zeta-isoform of protein-kinase-C in the maintenance of long-term potentiation
53. Mechanisms of potentiation by calcium-calmodulin kinase II of postsynaptic sensitivity in rat hippocampal CA1 neurons
54. Deficient hippocampal long-term potentiation in a calcium-calmodulin kinase II mutant mouse
55. Competitive cAMP antagonists for cAMP-receptor proteins
56. Postsynaptic protein-kinase-C essential to induction and maintenance of long-term potentiation in the hippocampal CA1 region
57. 2+/CaM induces synaptic potentiation requiring CaMKII and PKC activity
58. Mediation of hippocampal mossy fiber long-term potentiation by Cyclic AMP
59. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C
60. Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin