The apical organelles of malaria merozoites: Host cell selection, invasion, host immunity and immune evasion

Microbes and Infection

Volumn 2, Issue 12, 2000, Pages 1461-1477

  Preiser, Peter ^a   Kaviratne, Mallika ^a   Khan, Shahid ^a   Bannister, Lawrence ^b   Jarra, William ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Antigens; Dense granules; Erythrocyte; Immune evasion; Immunity; Invasion; Malaria; Merozoite; Micronemes; Proteins; Rhoptry

Indexed keywords

PARASITE ANTIGEN;

ANIMAL CELL; APICAL MEMBRANE; APICOMPLEXA; CELL ORGANELLE; ERYTHROCYTE; HOST CELL; HOST PARASITE INTERACTION; HUMAN; HUMAN CELL; IMMUNITY; MALARIA; MEROZOITE; NONHUMAN; PARASITE VIRULENCE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; REVIEW;

ANIMALIA; APICOMPLEXA; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0033759127     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(00)01301-0     Document Type: Review

References (149)

1. The current global malaria situation
2. Rhoptry organelles of the Apicomplexa: Their role in host cell invasion and intracellular survival
3. Invasion of vertebrate cells: Erythrocytes
4. Malaria vaccine development: Current status
5. Release of merozoite dense granules during erythrocyte invasion by Plasmodium knowlesi
6. The ultrastructure of red cell invasion in malaria infections: A review
7. The fine structure of secretion by Plasmodium knowlesi merozoites during red cell invasion
8. Malaria parasite invasion: Interactions with the red cell membrane
9. Lamellar membranes associated with rhoptries in erythrocytic merozoites of Plasmodium knowlesi: A clue to the mechanism of invasion
10. Interaction between cytochalasin B-treated malarial parasites and erythrocytes. Attachment and junction formation
11. Erythrocyte entry by malarial parasites. A moving junction between erythrocyte and parasite
12. Structure and invasive behaviour of Plasmodium knowlesi merozoites in vitro
13. Ultrastructure of rhoptry development in Plasmodium falciparum erythrocytic schizonts
14. Biogenesis of rhoptry organelles in Plasmodium falciparum
15. Fine structure of human malaria in vitro
16. The nuclear envelope serves as an intermediary between the ER and Golgi complex in the intracellular parasite Toxoplasma gondii
17. Plasmodium falciparum: Two antigens of similar size are located in different compartments of the rhoptry
18. Characterization of a 225 kilodalton rhoptry protein of Plasmodium falciparum
19. Plasmodium falciparum rhoptry proteins of 140/130/110 kD (Rhop-H) are located in an electron lucent compartment in the neck of the rhoptries
20. Rhoptry section of membranous whorls by Plasmodium falciparum merozoites
21. Red cell membrane protein distribution during malarial invasion
22. The role of lipids in Plasmodium falciparum invasion of erythrocytes: A coordinated biochemical and microscopic analysis
23. Characterization of the lipid content of Toxoplasma gondii rhoptries
24. The origin of parasitophrous vacuole membrane lipids in malaria-infected erythrocytes
25. The invasion of erythrocytes by malarial merozoites
26. Pf155/RESA antigen is localized in dense granules of Plasmodium falciparum merozoites
27. Plasmodium falciparum ring-infected erythrocyte surface antigen is released from merozoite dense granules after erythrocyte invasion
28. Transfer of a dense granule protein of Plasmodium falciparum to the membrane of ring stages and isolation of dense granules
29. Plasmodium knowlesi: Studies on invasion of rhesus erythrocytes by merozoites in the presence of protease inhibitors
30. Secretion of Plasmodium falciparum rhoptry protein into the plasma membrane of host erythrocytes
31. The ring-infected erythrocyte surface antigen of Plasmodium falciparum associates with spectrin in the erythrocyte membrane
32. Isolation of merozoite rhoptries identification of novel rhoptry-associated proteins from Plasmodium yoelii, P. chabaudi, P. berghei and conserved interspecies reactivity of organelles and proteins with P. falciparum rhoptry-specific antibodies
33. Morphological analysis of isolated rhoptries from Plasmodium yoelii P. berghei and P. chabaudi merozoites
34. Isolation and characterization of rhoptries of Plasmodium falciparum
35. Plasmodium yoelii: Identification of rhoptry proteins using monoclonal antibodies
36. Protective antigens of rodent and human bloodstage malaria
37. Isolation of a Plasmodium falciparum rhoptry protein
38. Ultrastructural localization of protective antigens of Plasmodium yoelii merozoites by the use monoclonal antibodies and ultra-thin cryomicrotomy
39. An antigenic complex in the rhoptries of Plasmodium falciparum
40. The 140/130/105 kilodalton protein complex in the rhoptries of Plasmodium falciparum consists of discrete polypeptides
41. A rhoptry antigen of Plasmodium falciparum contains conserved and variable epitopes recognized by inhibitory monoclonal antibodies
42. The 42-kilodalton rhoptry-associated protein of Plasmodium falciparum
43. Merozoite surface coat precursor protein completely protects Aotus monkeys against Plasmodium falciparum malaria
44. Characterisation and sequence of a protective rhoptry antigen from Plasmodium falciparum
45. Biosynthesis of a putative protective Plasmodium knowlesi merozoite antigen
46. Integral membrane protein located in the apical complex of Plasmodium falciparum
47. Apical membrane antigen of Plasmodium fragile
48. Structure of the apical membrane antigen I (AMA-1) of Plasmodium chabaudi
49. Sequence analysis of the apical membrane antigen I (AMA-1) of Plasmodium vivax
50. Differential localization of full-length and processed forms of PF83/AMA-1 an apical membrane antigen of Plasmodium falciparum merozoites
51. A merozoite receptor protein from Plasmodium knowlesi is highly conserved and distributed throughout Plasmodium
52. Sixty-six kilodalton-related antigens of Plasmodium knowlesi are merozoite surface antigens associated with the apical prominence
53. Analysis of the processing of Plasmodium falciparum rhoptry-associated protein 1 and localization of Pr86 to schizont rhoptries and p67 to free merozoites
54. Inhibitory monoclonal antibodies recognise epitopes adjacent to a proteolytic cleavage site on the RAP-1 protein of Plasmodium falciparum
55. Proteins responsible for a punctate fluorescence pattern in Plasmodium falciparum merozoites
56. RAP1 controls rhoptry targeting of RAP2 in the malaria parasite Plasmodium falciparum
57. A component of an antigenic rhoptry complex of Plasmodium falciparum is modified after merozoite invasion
58. Interaction of the 140/130/110 kDa rhoptry protein complex of Plasmodium falciparum with the erythrocyte membrane and liposomes
59. Analysis of the high molecular weight rhoptry complex of Plasmodium falciparum using monoclonal antibodies
60. Preferential binding of Plasmodium falciparum SERA and rhoptry proteins to erythrocyte membrane inner leaflet phospholipids
61. Primary structure of a Plasmodium falciparum rhoptry antigen
62. Molecular factors responsible for host cell recognition and invasion in Plasmodium falciparum
63. A large multigene family expressed during the erythrocytic schizogony of Plasmodium falciparum
64. Evidence for distinct prototype sequences within the Plasmodium falciparum Pf60 multigene family
65. Characterization of a new 60 kDa apical protein of Plasmodium falciparum merozoite expressed in late schizogony
66. A member of the Plasmodium falciparum Pf60 multigene family codes for a nuclear protein expressed by readthrough of an internal stop codon
67. Sudden increase in virulence in a strain of Plasmodium berghei yoelii
68. Protective monoclonal antibodies recognising stage-specific merozoite antigens of a rodent malaria parasite
69. Immunization against bloodstage rodent malaria using purified parasite antigens
70. Identification of the gene for a Plasmodium yoelii rhoptry protein. Multiple copies in the parasite genome
71. Multiple genes code for high-molecular-mass rhoptry proteins of Plasmodium yoelii
72. Comparison of two members of a multigene family coding for high-molecular mass rhoptry proteins of Plasmodium yoelii
73. Plasmodium yoelii: Differences in the transcription of the 235-kDa rhoptry protein multigene family in lethal and nonlethal lines
74. A high molecular mass Plasmodium yoelii rhoptry protein binds to erythrocytes
75. A gene coding for a high-molecular mass rhoptry protein of Plasmodium yoelii
76. Induction of the proteolytic activity of a membrane protein in Plasmodium falciparum by phosphatidyl inositol-specific phospholipase C
77. A family of chimeric erythrocyte binding proteins of malaria parasites
78. Plasmodium yoelii YM MAEBL protein is coexpressed and colocalizes with rhoptry proteins
79. A family of erythrocyte binding proteins of malaria parasites
80. The domain on the Duffy blood group antigen for binding Plasmodium vivax and P. knowlesi malarial parasites to erythrocytes
81. The Duffy receptor family of Plasmodium knowlesi is located within the micronemes of invasive malaria merozoites
82. Plasmodium vivax inter-action with the human Duffy blood group glycoprotein: Identification of a parasite receptor-like protein
83. EBL-1, a putative erythrocyte binding protein of Plasmodium falciparum, maps within a favored linkage group in two genetic crosses
84. Receptor and ligand domains for invasion of erythrocytes by Plasmodium falciparum
85. A Plasmodium falciparum antigen that binds to host erythrocytes and merozoites
86. Targeted disruption of an erythrocyte binding antigen in Plasmodium falciparum is associated with a switch toward a sialic acid-independent pathway of invasion
87. Erythrocyte binding protein homologues of rodent malaria parasites
88. A reticulocyte-binding protein complex of Plasmodium vivax merozoites
89. Plasmodium vivax: Merozoites, invasion of reticulocytes and considerations for malaria vaccine development
90. Monoclonal antibodies identify a subset of dense granules in Cryptosporidium parvum zoites and gamonts
91. Differential targeting of dense granule proteins in the parasitophorous vacuole of Toxoplasma gondii
92. A subtilisin-like protein in secretory organelles of Plasmodium falciparum merozoites
93. Rabbit and human antibodies to a repeated amino acid sequence of a Plasmodium falciparum antigen, Pf 155, react with the native protein and inhibit merozoite invasion
94. PfSUB-2: A second subrilisin-like protein in Plasmodium falciparum merozoites
95. Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite surface protein 1-42 maturase
96. A rhoptry-protein-associated mechanism of clonal phenotypic variation in rodent malaria
97. Chromosomal organisation of a gene family encoding rhoptry proteins in Plasmodium yoelii
98. Glycophorin B as an EBA-175 independent Plasmodium falciparum receptor of human erythrocytes
99. Evidence for a switching mechanism in the invasion of erythrocytes by Plasmodium falciparum
100. Antigenic variation of cloned Plasmodium fragile in its natural host Macaca sinica
101. Plasmodium falciparum: A high proportion of parasites from a population of the Dd2 strain are able to invade erythrocytes by an alternative pathway
102. Invasion of erythrocytes by Plasmodium falciparum malaria parasites: Evidence for receptor heterogeneity and two receptors
103. Evidence for two-stage binding by the 175-kD erythrocyte binding antigen of Plasmodium falciparum
104. Identification of an erythrocyte binding peptide from the erythrocyte binding antigen, EBA-175, which blocks parasite multiplication and induces peptide-blocking antibodies
105. Plasmodium falciparum field isolates commonly use erythrocyte invasion pathways that are independent of sialic acid residues of glycophorin A
106. The Fab fragments of monoclonal IgG to a merozoite surface antigen inhibit Plasmodium knowlesi invasion of erythrocytes
107. Vaccination trials in rhesus monkeys with a minor invariant Plasmodium knowlesi 66 kD merozoite antigen
108. Protective immunity induced in squirrel monkeys with recombinant apical membrane antigen-1 of Plasmodium fragile
109. Protective immune responses to apical membrane antigen 1 of Plasmodium chabaudi involve recognition of strain-specific epitopes
110. Specific T-cell recognition of the merozoite proteins rhoptry-associated protein 1 and erythrocyte-binding antigen 1 of Plasmodium falciparum
111. A study of antibody and T cell recognition of rhoptry-associated protein-1 (RAP-1) and RAP-2 recombinant proteins and peptides of Plasmodium falciparum in migrants and residents of the state of Rondonia, Brazil
112. Assessment of the humoral immune response against Plasmodium falciparum rhoptry-associated proteins 1 and 2
113. Antibody responses to rhoptry-associated protein-1 (RAP-1) of Plasmodium falciparum parasites in humans from areas of different malaria endemicity
114. Immunoglobulin G reactivities to rhoptry-associated protein-1 associated with decreased levels of Plasmodium falciparum parasitemia in Tanzanian children
115. IgG reactivities against recombinant rhoptry-associated protein-1 (rRAP-1) are associated with mixed Plasmodium infections and protection against disease in Tanzanian children (In Process Citation)
116. Reactivity profile of human anti-82-kilodalton rhoptry protein antibodies generated during natural infection with Plasmodium falciparum
117. A longitudinal study of human antibody responses to Plasmodium falciparum rhoptry-associated protein 1 in a region of seasonal and unstable malaria transmission
118. A rhoptry antigen of Plasmodium falciparum is protective in Saimiri monkeys
119. Limited RAP-1 sequence diversity in field isolates of Plasmodium falciparum
120. Seroprevalence and specificity of human responses to the Plasmodium falciparum rhoptry protein Rhop-3 determined by using a C-terminal recombinant protein
121. Expression and serologic activity of a soluble recombinant Plasmodium vivax Duffy binding protein
122. Naturally acquired and vaccine-elicited antibodies block erythrocyte cytoadherence of the Plasmodium vivax Duffy binding protein
123. Characterization of the 175-kilodalton erythrocyte binding antigen of Plasmodium falciparum
124. EBA-175: An erythrocyte-binding ligand of Plasmodium falciparum
125. 1t
126. Sequence conservation of a functional domain of erythrocyte binding antigen 175 in Plasmodium falciparum
127. Primary structure of the 175K Plasmodium falciparum erythrocyte binding antigen and identification of a peptide which elicits antibodies that inhibit malaria merozoite invasion
128. Plasmodium falciparum: Further characterization of a functionally, active region of the merozoite invasion ligand EBA-175
129. Baculovirus-mediated expression of Plasmodium falciparum erythrocyte binding antigen 175 polypeptides and their recognition by human antibodies
130. Human antibodies to a mr 155,000 Plasmodium falciparum antigen efficiently inhibit merozoite invasion
131. Assessment of the role of the humoral response to Plasmodium falciparum MSP2 compared to RESA and SPf66 in protecting Papua New Guinean children from clinical malaria
132. T and B cell responses of Plasmodium falciparum malaria-immune individuals to synthetic peptides corresponding to sequences in different regions of the P. falciparum antigen Pf155/RESA
133. Immunization of Aotus monkeys with recombinant proteins of an erythrocyte surface antigen of Plasmodium falciparum
134. Immunization of owl monkeys with the ring-infected erythrocyte surface antigen of Plasmodium falciparum
135. The Plasmodium falciparum protein RESA interacts with the erythrocyte cytoskeleton and modifies erythrocyte thermal stability
136. Human monoclonal antibodies to Pf 155, a major antigen of malaria parasite Plasmodium falciparum
137. Involvement of Pf155/RESA and cross-reactive antigens in Plasmodium falciparum merozoite invasion in vitro
138. A hypothesis about the chronicity of malaria infection
139. The role of variant-specific immunity in asymptomatic malaria infections: Maintaining a fine balance
140. A single gene copy merozoite surface antigen and immune evasion?
141. The role of variant surface antigens on malaria-infected red blood cells
142. Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria
143. Antibodies that inhibit malaria merozoite surface protein-1 processing and erythrocyte invasion are blocked by naturally acquired human antibodies
144. Malaria multigene families: The price of chronicity
145. Complementation of a Toxoplasma gondii ROP1 knock-out mutant using phleomycin selection
146. A Plasmodium chabaudi protein contains a repetitive region with a predicted spectrin-like structure
147. A polyclonal but not a monoclonal antibody to an M(r) 52-kD protein responsible for a punctate fluorescence pattern in Plasmodium falciparum merozoites inhibits invasion in vitro