A member of the Plasmodium falciparum Pf60 multigene family codes for a nuclear protein expressed by readthrough of an internal stop codon

Molecular Microbiology

Volumn 35, Issue 5, 2000, Pages 1005-1016

  Bischoff, E ^a   Guillotte, M ^a   Mercereau Puijalon, O ^a   Bonnefoy, S ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE ZIPPER PROTEIN; LUCIFERASE; MEMBRANE PROTEIN; NUCLEAR PROTEIN;

AMINO TERMINAL SEQUENCE; ANTIGENIC VARIATION; ARTICLE; CARBOXY TERMINAL SEQUENCE; ERYTHROCYTE MEMBRANE; EXON; GENE EXPRESSION; GENETIC CODE; GENETIC TRANSFECTION; IMMUNOASSAY; MULTIGENE FAMILY; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN INTERACTION; REPORTER GENE; RNA TRANSLATION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STOP CODON;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CLONING, MOLECULAR; CODON, TERMINATOR; DNA, COMPLEMENTARY; FEMALE; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; NUCLEAR PROTEINS; OPEN READING FRAMES; PLASMODIUM FALCIPARUM; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSFECTION;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0034107648     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2000.01788.x     Document Type: Article

References (49)

1. Albers, K., and Fuchs, E. (1992) The molecular biology of intermediate filament proteins. Int Rev Cytol 134: 243-279.
2. Baruch, D.I., Pasloske, B.L., Singh, H.B., Bi, X., Ma, X.C., Feldman, M., et al. (1995) Cloning the P. falciparum gene encoding PfEMP1, a malarial antigen and adherence receptor on the surface of parasitized human erythrocytes. Cell 82: 77-87.
3. Birnstiel, M.L., Busslinger, M., and Strub, K. (1985) Transcription termination and 3′ processing: the end is in site. Cell 41: 349-359.
4. Bjornsson, A., Mottagui-Tabar, S., and Isaksson, L.A. (1996) Structure of the C-terminal end of the nascent peptide influences translation termination. EMBO J 15: 1696-1704.
5. Böck, A., Forchhammer, K., Heider, J., and Baron, C. (1991) Selenoprotein synthesis: an expansion of the genetic code. Trends Biochem Sci 16: 463-467.
6. Bonnefoy, S., Guillotte, M., Langsley, G., and Mercereau-Puijalon, O. (1992) Plasmodium falciparum: characterization of gene R45 encoding a trophozoite antigen containing a central block of six amino acid repeats. Exp Parasitol 74: 441-451.
7. Bonnefoy, S., Bischoff, E., Guillotte, M., and Mercereau-Puijalon, O. (1997) Evidence for distinct prototype sequences within the Plasmodium falciparum Pf60 multigene family. Mol Biochem Parasitol 87: 1-11.
8. Bowman, S., Lawson, D., Basham, D., Brown, D., Chillingworth, T., Churcher, C.M., et al. (1999) The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Nature 400: 532-538.
9. Brenner, S.E., Hubbard, T., Murzin, A., and Chothia, C. (1995) Gene duplications in H. influenzae. Nature 378: 140.
10. Carcy, B., Bonnefoy, S., Guillotte, M., Le Scanf, C., Grellier, P., Schrevel, J., et al. (1994) A large multigene family expressed during the erythrocytic schizogony of Plasmodium falciparum. Mol Biochem Parasitol 68: 221-233.
11. Chen, E., and Seeburg, P. (1985) Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. DNA 4: 165-170.
12. Chen, Q., Fernandez, V., Sundstrom, A., Schlichtherle, M., Datta, S., Hagblom, P., and Wahlgren, M. (1998) Developmental selection of var gene expression in Plasmodium falciparum. Nature 394: 392-395.
13. Cheng, Q., Cloonan, N., Fischer, K., Thomson, J., Waine, G., Lanzer, M., and Saul, A. (1998) stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens. Mol Biochem Parasitol 97: 161-176.
14. Deitsch, K.W., and Wellems, T.E. (1996) Membrane modifications in erythrocytes parasitized by Plasmodium falciparum. Mol Biochem Parasitol 76: 1-10.
15. Fandeur, T., Bonnefoy, S., and Mercereau-Puijalon, O. (1991) In vivo and in vitro derived Palo Alto lines of Plasmodium falciparum are genetically unrelated. Mol Biochem Parasitol 47: 167-178.
16. Farabaugh, P.J. (1996) Programmed translational frameshifting. Microbiol Rev 60: 103-134.
17. Gardner, M.J., Tettelin, H., Carucci, D.J., Cummings, L.M., Aravind, L., Koonin, E.V., et al. (1998) Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science 282: 1126-1132.
18. Gesteland, R.F., and Atkins, J.F. (1996) Recoding: dynamic reprogramming of translation. Annu Rev Biochem 65: 741-768.
19. Grellier, P., Precigout, E., Valentin, A., Carcy, B., and Schrevel, J. (1994) Characterization of a new 60 kDa apical protein of Plasmodium falciparum merozoites. Biol Cell 82: 129-138.
20. Hall, R., Hyde, J.E., Goman, M., Simmons, D.L., Hope, I.A., Mackay, M., and Scaife, J. (1984) Major surface antigen of a human malaria parasite cloned and expressed in bacteria. Nature 311: 379-382.
21. Henikoff, S., Greene, E.A., Pietrokovski, S., Bork, P., Attwood, T.K., and Hood, L. (1997) Gene families: the taxonomy of protein paralogs and chimeras. Science 278: 609-614.
22. Hughes, D., Atkins, J.F., and Thompson, S. (1987) Mutants of elongation factor Tu promote ribosomal frameshifting and nonsense readthrough. EMBO J 6: 4235-4239.
23. Kappe, S.H.I., Noe, A.R., Fraser, T.S., Blair, P.L., and Adams, J.H. (1998) A family of chimeric erythrocyte binding proteins of malaria parasites. Proc Natl Acad Sci USA 95: 1230-1235.
24. Kyes, S.A., Rowe, J.A., Kriek, N., and Newbold, C.I. (1999) Rifins: a second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum. Proc Natl Acad Sci USA 96: 9333-9338.
25. Labedan, B., and Riley, M. (1995) Gene products of Escherichia coli: sequence comparisons and common ancestries. Mol Biol Evol 12: 980-987.
26. Limpaiboon, T., Shirley, M.W., Kemp, D.J., and Saul, A. (1991) 7H8/6, a multicopy DNA probe for distinguishing isolates of Plasmodium falciparum. Mol Biochem Parasitol 47: 197-206.
27. Lupas, A., Van Dyke, M., and Stock, J. (1991) Predicting coiled coils from protein sequences. Science 252: 1162-1164.
28. McCaughan, K.K., Brown, C.M., Dalphin, M.E., Berry, M.J., and Tate, W.P. (1995). Translational termination efficiency in mammals is influenced by the base following the stop codon. Proc Natl Acad Sci USA 92: 5431 -5435.
29. Mostov, K.E., Friedlander, M., and Blobel, G. (1984) The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains. Nature 308: 37-43.
30. Mottagui-Tabar, S., Bjornsson, A., and Isaksson, L.A. (1994) The second to last amino acid in the nascent peptide as a codon context determinant. EMBO J13: 249-257.
31. Rawlings, D.J., and Kaslow, D.C. (1992) A novel 40-kDa membrane-associated EF-hand calcium-binding protein in Plasmodium falciparum. J Biol Chem 267: 3976-3982.
32. Robert, F., Ntoumi, F., Angel, G., Candito, D., Rogier, C., Fandeur, T., et al. (1996) Extensive genetic diversity of Plasmodium falciparum isolates collected from patients with severe malaria in Dakar, Senegal. Trans R Soc Trop Med Hyg 90: 704-711.
33. Roggwiller, E., Fricaud, A.C., Blisnick, T., and Braun-Breton, C. (1997) Host urokinase-type plasminogen activator participates in the release of malaria merozoites from infected erythrocytes. Mol Biochem Parasitol 86: 49-59.
34. Rowe, J.A., Moulds, J.M., Newbold, C.I., and Miller, L.H. (1997) P. falciparum resetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1. Nature 388: 292-295.
35. Sandbaken, M.G., and Culbertson, M.R. (1988) Mutations in elongation factor EF-1 alpha affect the frequency of frameshifting and amino acid misincorporation in Saccharomyces cerevisiae. Genetics 120: 923-934.
36. Scherf, A., Hernandez-Rivas, R., Buffet, P., Bottius, E., Benatar, C., Pouvelle, B., et al. (1998) Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum. EMBO J 17: 5418-5426.
37. Smith, D., and Johnson, K. (1988) Single-step purification of polypeptides expressed in Escherichia coli as fusion proteins with glutathione S-transferase. Gene 67: 31-40.
38. Smith, J.D., Chitnis, C.E., Craig, A.G., Roberts, D.J., Hudson-Taylor, D.E., Peterson, D.S., et al. (1995) Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes. Cell 82: 101-110.
39. Su, X., Heatwole, V.M., Wertheimer, S.P., Guinet, F., Herrfeldt, J.A., Peterson, D.S., and Ravetch, J.A. (1995) The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes. Cell 82: 89-100.
40. Suarez, C.E., McElwain, T.F., Stephens, E.B., Mishra, V.S., and Palmer, G.H. (1991) Sequence conservation among merozoite apical complex proteins of Babesia bovis, Babesia bigemina and other Apicomplexa. Mol Biochem Parasitol 49: 329-332.
41. Tate, W.P., Poole, E.S., Dalphin, M.E., Major, L.L., Crawford, D.J., and Mannering, S.A. (1996) The translational stop signal: codon with a context, or extended factor recognition element? Biochimie 78: 945-952.
42. Tatusov, R.L., Koonin, E.V., and Lipman, D.J. (1997) A genomic perspective on protein families. Science 278: 631-637.
43. Ternynck, T., Falanga, P.B., Unterkirscher, C., Gregoire, J., da Silva, L.P., and Avrameas, S. (1991) Induction of high levels of IgG autoantibodies in mice infected with Plasmodium chabaudi. Int Immunol 3: 29-37.
44. Thompson, J.K., Rubio, J.P., Caruana, S., Brockman, A., Wickham, M.E., and Cowman, A.F. (1997) The chromosomal organization of the Plasmodium falciparum var gene family is conserved. Mol Biochem Parasitol 87: 49-60.
45. Vinkenoog, R., Veldhuisen, B., Speranca, M.A., del Portillo, H.A., Janse, C., and Waters, A.P. (1995) Comparison of introns in a cdc2-homologous gene within a number of Plasmodium species. Mol Biochem Parasitol 71: 233-241.
46. Walliker, D., Quakyi, I.A., Wellems, T.E., McCutchan, T.F., Szarfman, A., London, W.T., et al. (1987) Genetic analysis of the human malaria parasite Plasmodium falciparum. Science 236: 1661-1666.
47. Weber, J.L. (1988) Interspersed repetitive DNA from Plasmodium falciparum. Mol Biochem Parasitol 29: 117-124.
48. Wu, Y., Sifri, C.D., Lei, H.H., Su, X.Z., and Wellems, T.E. (1995) Transfection of Plasmodium falciparum within human red blood cells. Proc Natl Acad Sci USA 92: 973-977.
49. Yamauchi, K. (1991) The sequence flanking translational initiation site in protozoa. Nucleic Acids Res 19: 2715-2720.