Neuroendocrine evidence that clozapine's serotonergic antagonism is relevant to its efficacy in treating hallucinations and other positive schizophrenic symptoms

American Journal of Psychiatry

Volumn 155, Issue 6, 1998, Pages 838-840

  Jones, Hugh ^b   Curtis, Vivienne A ^b   Wright, Padraig ^b   Lucey, James V ^a  

^a Royal College of Surgeons in Ireland   (Ireland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; FENFLURAMINE; PROLACTIN; SEROTONIN; SEROTONIN ANTAGONIST;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DELUSION; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; FEMALE; HALLUCINATION; HUMAN; MALE; NEGATIVE SYNDROME; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SCHIZOPHRENIA; SEROTONIN RELEASE;

ADULT; ANTIPSYCHOTIC AGENTS; CLOZAPINE; FEMALE; FENFLURAMINE; HALLUCINATIONS; HUMANS; MALE; PROLACTIN; PSYCHIATRIC STATUS RATING SCALES; RECEPTORS, SEROTONIN; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SEROTONIN ANTAGONISTS; TREATMENT OUTCOME;

EID: 0031745928     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Kane J, Honigfeld G, Singer J, Meltzer H: Clozapine for the treatment-resistant schizophrenic: a douhle-blind comparison with chlorpromazine. Arch Gen Psychiatry 1988; 45:789-796
2. 2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients. Am J Psychiatry 1995; 152:1444-1449
3. Wooley DW, Shaw E: A biochemical and pharmacological suggestion about certain mental disorders. Proc Natl Acad Sci USA 1954; 40:228-231
4. Kahn RS, Davidson M, Siever L, Gabriel S, Apter S, Davis KL: Serotonin function and treatment response to clozapine in schizophrenic patients. Am J Psychiatry 1993; 150:1337-1342
5. Owen RR, Guhewez-Estinou R, Hsiao J, Hadd K, Benkelfat C, Murphy DL, Lawlor BA, Pickar D: Effects of clozapine and fluphenazine treatment on responses to m-chlorophenylpiperazine infusions in schizophrenia. Arch Gen Psychiatry 1993; 50: 636-644
6. Curtis VA, Wright P, Reveley A, Kerwin R, Lucey JV: Effect of clozapine on d-fenfluramine evoked neuroendocrine responses in schizophrenia and its relation to clinical improvement. Br J Psychiatry 1995; 166:642-646
7. Invernizzi R, Berettera C, Garattini S, Samanin R: d- and l-isomers of fenfluramine differ markedly in their interaction with brain serotonin and catecholamines in the rat. Eur J Pharmacol 1986; 20:9-15
8. Garattini S, Mennini T, Samanin R: From fenfluramine racemate to d-fenfluramine: specificity and potency of the effects on the serotoninergic system and food intake. Ann NY Acad Sci 1987; 499:156-166
9. Goodall EM, Cowen PJ, Franklin M, Silverstone T: Ritanserin attenuates anorexic responses to d-fenfluramine in human volunteers. Psychopharmacology (Berl) 1993; 499:156-166
10. Andreasen NC: Scale for the Assessment of Positive Symptoms (SAPS). Iowa City, University of Iowa, 1983
11. Andreasen NC: Scale for the Assessment of Negative Symptoms (SANS). Iowa City, University of Iowa, 1981
12. Breier A: Serotonin, schizophrenia and antipsychotic drug action. Schizophr Res 1995; 14:187-202
13. Meltzer HY: Clozapine: is another view valid? (editorial). Am J Psychiatry 1995; 152:821-825