Lack of modification by environmental estrogenic compounds of thyroid carcinogenesis in ovariectomized rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN)

Japanese Journal of Cancer Research

Volumn 91, Issue 10, 2000, Pages 966-972

  Son, Hwa Young ^a   Nishikawa, Akiyoshi ^a   Ikeda, Takako ^a,b   Furukawa, Fumio ^a   Hirose, Masao ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b SHOWA WOMEN'S UNIVERSITY   (Japan)

Author keywords

3 Chloro 4 (dichloromethyl) 5 hydroxy 2(5H) furanone; Genistein; Nonylphenol; Ovariectomy; Thyroid carcinogenesis

Indexed keywords

3 CHLORO 4 DICHLOROMETHYL 5 HYDROXY 2(5H) FURANONE; ANTITHYROID AGENT; BIS(2 HYDROXYPROPYL)NITROSAMINE; CHOLESTEROL; DAIDZEIN; DRINKING WATER; DRUG VEHICLE; ENVIRONMENTAL CHEMICAL; ESTRADIOL BENZOATE; ESTROGEN DERIVATIVE; GENISTEIN; GLYCITEIN; HORMONE DERIVATIVE; ISOFLAVONE DERIVATIVE; NONYLPHENOL; SULFADIMETHOXINE; TUMOR PROMOTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CANCER MODEL; CANCER PREVENTION; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG INDUCED CANCER; FEMALE; HISTOPATHOLOGY; HYPOPHYSIS; KERATINIZATION; KIDNEY MASS; KIDNEY TUBULE DISORDER; LIVER; NONHUMAN; ORGAN WEIGHT; OVARIECTOMY; PANCREAS ISLET CELL TUMOR; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; SQUAMOUS CELL METAPLASIA; TELANGIECTASIA; THYROID CARCINOMA; THYROID TUMOR; THYROID WEIGHT; UTERUS TUMOR; UTERUS WEIGHT; VAGINA DISEASE;

AMINOACRIDINES; ANIMALS; ANTICARCINOGENIC AGENTS; BODY WEIGHT; CARCINOGENICITY TESTS; CARCINOGENS; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENISTEIN; ISOFLAVONES; NITROSAMINES; ORGAN SIZE; OVARIECTOMY; PHENOLS; RATS; RATS, INBRED F344;

EID: 0033756503     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2000.tb00872.x     Document Type: Article

References (59)

1. Mechanistic data and risk assessment of selected toxic end points of the thyroid gland
2. Detection of thyroid toxicants in a tier I screening battery and alterations in thyroid endpoints over 28 days of exposure
3. Castration induces a marked reduction in the incidence of thyroid cancers
4. Sex hormone modulation of serum TSH levels
5. Testosterone enhancement of thyroid carcinoma in rats: The role of TSH
6. Effects of sex difference, gonadectomy, and estrogen on N-methyl-N-nitrosourea induced rat thyroid tumors
7. Synthesis of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, a potent mutagen
8. Microwave mediated synthesis of genistein
9. Effect of thyroid stimulating hormone on the development and progression of rat thyroid follicular cell tumors
10. Dramatic synergism between excess soybean intake and iodine deficiency on the development of rat thyroid hyperplasia
11. Effect of dietary genistein on antioxidant enzyme activities in SENCAR mice
12. Effects of p-nonylphenol (NP) and diethylstilboestrol (DES) on the Alderley Park (Alpk) rat: Comparison of mammary gland and uterus sensitivity following oral gavage or implanted mini-pumps
13. Enhancing effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) on cell proliferation and lipid peroxidation in the rat gastric mucosa
14. Promoting effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine
15. Proliferative lesions of the thyroid and parathyroid glands, E-3
16. Lack of modifying effects of environmental estrogenic compounds on the development of thyroid proliferative lesions in male rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN)
17. Effect of chronic estrogen treatment of Syrian hamsters on microsomal enzymes mediating formation of catechol estrogens and their redox cycling: Implications for carcinogenesis
18. Role of activation of ornithine decarboxylase and DNA synthesis on ethynylestradiol-induced hepatocarcinogenesis
19. Neoplastic responses and correlated plasma prolactin levels in diethylstilberol-treated ACI and Sprague-Dawley rats
20. Ovary intact, but not ovariectomized female ACI rats treated with 17β-estradiol rapidly develop mammary carcinoma
21. Thyroxine metabolism and thyroid function in the pregnant rat
22. Effects of estradiol benzoate on thyroid-pituitary function in female rats
23. Influence of estrogen on the pituitary-thyroid system of the female rat: Mechanisms and loci of action
24. Estrogen action in vitro: Regulation of thyroid stimulating and other pituitary hormones in cell cultures
25. Decrease of free thyroxine levels after controlled ovarian hyperstimulation
26. Chemical carcinogenesis and sex hormones in experimental thyroid tumors
27. Increase in estrogen receptor levels in MNU-induced thyroid tumors in LE rats
28. The other oestrogen receptor in the plasma membrane: Implications for the actions of environmental oestrogens
29. Rapid screening of environmental chemicals for estrogen receptor binding capacity
30. Development of a tier 1 screening battery for detecting endocrine-active compounds (EACs)
31. Expression of the estrogen receptor in human thyroid neoplasms
32. A PCR analysis of ERalpha and ERbeta mRNA abundance in rats and the effect of ovariectomy
33. Estrogen and progesterone receptors in thyroid lesions
34. Estrogen receptors and glucocorticoid receptors in human well-differentiated thyroid cancer
35. Hormones and mammary carcinogenesis in mice, rats, and humans: A unifying hypothesis
36. Induction of uterine adenocarcinoma in CD-1 mice by catechol estrogens
37. Oviduct, uterus, and vagina
38. Direct and indirect influences of a 14 days oestradiol-17 beta treatment on the endocrine pancreas of the female rat
39. Effect of 2-hydroxyoestradiol on insulin secretion in normal rat pancreatic islets
40. Occurrence of goiter in an infant on a soy diet
41. The goitrogenic action of soybean and groundnut
42. Separation of a thyroid-active fraction from unheated soya bean flour
43. Development of malignant goiter by defatted soybean with iodine-free diet in rats
44. Anti-thyroid isoflavones from soybean: Isolation, characterization, and mechanisms of action
45. Effects of mammalian and plant estrogens on mammary glands and uteri of macaques
46. Dietary genistein exerts estrogenic effects upon the uterus, mammary gland and the hypothalamic/pituitary axis in rats
47. A case of a laboratory animal feed with high estrogenic activity and its impact on in vivo responses to exogenously administered estrogens
48. Developmental effects of dietary phytoestrogens in Sprague-Dawley rats and interactions of genistein and daidzein with rat estrogen receptors alpha and beta in vitro
49. In vivo estrogenic action of nonylphenol in immature female rats
50. Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats
51. Subchronic toxicity (90-day) study with para-nonylphenol in rats
52. The effects of 4-nonylphenol in rats: A multigeneration reproduction study
53. Phytoestrogens
54. Activity of raloxifene in immature and ovariectomized rat uterotrophic assays
55. Mutagenic potency of chlorofuranones and related compounds in Salmonella
56. Mutagenic and elastogenic properties of 3-chloro-4-(dichloromethyl)-5-hydroxy-2 (5H)-furanone: A potent bacterial mutagen in drinking water
57. Genotoxicity and cell proliferative activity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2 (5H)-furanone (MX) in rat glandular stomach
58. Carcinogenicity of the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone in the rat