Design and synthesis of a potent selective endothelin-converting enzyme inhibitor, CGS 35066

Journal of Cardiovascular Pharmacology

Volumn 36, Issue 5 SUPPL. 1, 2000, Pages

  Jeng, A Y ^a   De Lombaert, S ^a   Beil, M E ^a   Bruseo, C W ^a   Savage, P ^a   Chou, M ^a   Trapani, A J ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

CGS 35066; CGS 35339; Endothelin converting enzyme (ECE); Inhibitors; Neutral endopeptidase 24.11; Zinc metalloprotease

Indexed keywords

2 (4 BIPHENYLYL) 1 (1H TETRAZOL 5 YL)ETHYLAMINOMETHYLPHOSPHONIC ACID; BIG ENDOTHELIN 1; CARBOXYLIC ACID; CGS 31447; CGS 34043; CGS 35066; CGS 35339; DIBENZOFURAN; ENDOTHELIN CONVERTING ENZYME INHIBITOR; MEMBRANE METALLOENDOPEPTIDASE; PHENYL GROUP; PHOSPHONIC ACID DERIVATIVE; PHOSPHORAMIDON; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; MALE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT;

EID: 0033755954     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200036001-00117     Document Type: Article

References (10)

1. The clinical potential of endothelin receptor antagonists in cardiovascular medicine
2. Endothelins in the normal and diseased kidney
3. Therapeutic potential of endothelin receptor antagonists in cerebrovascular disease
4. Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene
5. ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
6. Therapeutic potential of endothelin converting enzyme inhibitors
7. Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme
8. Purification and specificity of a membrane-bound metalloendopeptidase from bovine pituitaries
9. Inhibition of big ET-1-induced pressor response by an orally active dual inhibitor of endothelin-converting enzyme and neutral endopeptidase 24.11
10. Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase 24.11