Effects of the peripherally selective κ-opioid asimadoline, on substance P and CGRP mRNA expression in chronic arthritis of the rat

Neuropeptides

Volumn 34, Issue 3-4, 2000, Pages 193-202

  Walker, J S ^a   Scott, C ^a   Bush, K A ^a   Kirkham, B W ^b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b ST GEORGE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ASIMADOLINE; CALCITONIN GENE RELATED PEPTIDE; KAPPA OPIATE RECEPTOR AGONIST; MESSENGER RNA; NEUROPEPTIDE; SUBSTANCE P;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC ARTHRITIS; CONTROLLED STUDY; DRUG MECHANISM; IMMUNOMODULATION; MALE; NERVE ENDING; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; SENSORY NERVE; SPINAL GANGLION;

EID: 0033754719     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1054/npep.2000.0813     Document Type: Article

References (40)

1. Involvement of substance P in the anti-inflammatory effects of the peripherally selective κopioid asimadoline and the NK1 antagonist GR205171
2. Effect of the peripherally selective κopioid agonist, asimadoline, on adjuvant arthritis
3. + evoked substance P release from rat peripheral airways
4. Acute effects of morphine on substance P concentrations in microdissected regions of guinea-pig brain
5. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
6. Reinnervation of post-arthritic joints in the rat
7. Increased expression of preprotachykinin, calcitonin gene-related peptide, but not vasoactive intestinal peptide messenger RNA in dorsal root ganglia during the development of adjuvant monoarthritis in the rat
8. Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo
9. Plasticity in the synthesis and storage of substance P and calcitonin gene related peptide in primary afferent neurones during peripheral inflammation
10. Changes in preprotachykinin mRNA expression and substance P levels in dorsal root ganglia of monoarthritic rats: Comparison with changes In synovial substance P levels
11. The effect of a unilateral inflammation at the rat's ankle joint on the expression of preprotachykinin-A mRNA and preprosomatostatin mRNA in the dorsal root ganglion cells - A study using non-radioactive in situ hybridization
12. The proportion of CGRP-immunoreactive and SP-mRNA containing dorsal root ganglion cells is increased by a unilateral inflammation of the ankle joint of the rat
13. Preprotachykinin mRNA expression in the synovial tissue of chronic arthritis
14. Cellular localization of peptides in neural structures
15. Kappa opioid analgesics
16. The arthritic rat as a model of clinical pain?
17. Increased calcitonin gene-related peptide (CGRP), substance P, and enkephalin immunoreactivities in dorsal spinal cord and loss of CGRP-immunoreactive motorneurones in arthritic rats depend on intact peripheral nerve supply
18. A neurogenic mechanism for symmetrical arthritis
19. Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A
20. Calcitonin gene-related peptide increases in the dorsal root ganglia of adjuvant arthritic rat
21. Identification of a delta isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes
22. The effects of tachykinins on inflammatory and immune cells
23. NK-1 and NK-3 type tachykinin receptors mRNA expression in the rat spinal cord dorsal horn is increased during adjuvant or formalin-induced nociception
24. Enhancement of preprotachykinin A gene expression by adjuvant-induced inflammation in the rat spinal cord: Possible involvement of substance P-containing spinal neurons in nociception
25. Adjuvant-induced inflammation of the rat paw is associated with altered calcitonin gene-related peptide immunoreactivity within cell bodies and peripheral endings of primary afferent neurons
26. Coexpression of alpha-CGRP and beta-CGRP mRNA in the rat dorsal root ganglion cells
27. Changes in the mRNA expression pattern with special reference to calcitonin gene related peptide, after axonal injuries in rat motorneurons depends on age and type of injury
28. Afferent and spinal mechanisms of joint pain
29. Evidence for opioid receptors on cells involved in host defence and the immune system
30. Activation of kappa opioid receptors by U50488H and morphine enhances the release of substance P from rat trigeminal nucleus slices
31. Dermatome mapping in the hindlimb by electrical stimulation of the spinal nerves
32. Immunohistochemical localization of calcitonin gene-related peptide in the human gastric mucosa
33. Neurokinin antagonists as potential therapies for inflammation and rheumatoid arthritis
34. Immunopharmacology of opioids in inflammatory arthritis
35. Effect of mu-opioids morphine and buprenorphine on the development of adjuvant arthritis in rats
36. The anti-inflammatory effects of opioids: Their possible relevance to the pathophysiology and treatment of rheumatoid arthritis
37. The site of anti-arthritic action of the κ-opioid, U-50, 488H, in adjuvant arthritis: Importance of local administration
38. Intercellular adhesion molecule-1 expression in adjuvant arthritis in rats: Inhibition by κ-opioid agonist but not by NSAID