Morphine has a dual concentration-dependent effect on K+-evoked substance P release from rat peripheral airways

Pulmonary Pharmacology and Therapeutics

Volumn 10, Issue 4, 1997, Pages 215-221

  Cabot, Peter J ^a   Cramond, Tess ^b   Smith, Maree T ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b NONE

Author keywords

Morphine; Naloxone; Opioid binding sites; Rat peripheral airways; Substance P; Superfusion

Indexed keywords

MORPHINE; NALOXONE; OPIATE AGONIST; OPIATE ANTAGONIST; OPIATE RECEPTOR; POTASSIUM ION; SUBSTANCE P;

AIRWAY; ANIMAL TISSUE; ARTICLE; DRUG ANTAGONISM; DRUG BINDING SITE; LUNG; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031215164     PISSN: 10945539     EISSN: None     Source Type: Journal    
DOI: 10.1006/pupt.1997.0094     Document Type: Article

References (30)

1. 1. Davis C L. Dyspnoea in palliative care. Br Med J 1992; 305: 1158.
2. 2. Farncombe M, Chater S. Clinical application of nebulized opioids for treatment of dyspnoea in patients with malignant disease. Support Care Cancer 1994; 2: 184-187.
3. 3. Fuller R W, Karlsson J A, Choudry N B, Pride N B. Effect of inhaled and systemic opiates on responses to inhaled capsaicin in humans. J Appl Physiol 1988; 65: 1125-1130.
4. 4. Cabot P J, Dodd P R, Cramond T, Smith M T. Characterization of non-conventional opioid binding sites in rat and human lung. Eur J Pharmacol 1994; 268: 247-255.
5. 5. Cabot P J, Cramond T, Smith M T. Quantitative autoradiography of peripheral opioid binding sites in rat lung. Eur. J. Pharmacol 1996; 310: 47-53.
6. 6. Sibinga N E, Goldstein A. Opioid peptides and opioid receptors in cells of the immune system. Ann Rev Immunol 1988; 6: 219-249.
7. 7. Ovadia H, Nitsan P, Abramsky O. Characterization of opiate binding sites on membranes of rat lymphocytes. J Neuroimmunol 1989; 21: 93-102.
8. 3-opiate receptors. Eur J Pharmacol 1995; 273: R5-R6.
9. 9. Roy S, Loh H H. Effects of opioids on the immune system. Neurochem. Res. 1996; 21: 1375-1386.
10. 10. Frossard N, Barnes P H. Mu-opioid receptors modulate non-cholinergic constrictor nerves in guinea-pig airways. Eur J Pharmacol 1987; 141: 519-522.
11. 11. Bartho L, Amman R, Saria A, Szolcsanyi J, Lembeck F. Peripheral effects of opioid drugs on capsaicin-sensitive neurones of the guinea-pig bronchus and rabbit ear. 1987; 336: 316-320.
12. 12. Belvisi M G, Stretton C D, Barnes P J. Modulation of cholinergic neurotransmission in guinea-pig airways by opioids. 1990; 100: 131-137.
13. 13. Lundberg J M, Brodin E, Saria A. Effects and distribution of vagal capsaicin-sensitive substance P neurons with special reference to the trachea and lungs. Acta Physiol Scand 1983; 119: 243-252.
14. 14. Laduron P M. Axonal transport of opiate receptors in capsaicin-sensitive neurones. Brain Res 1984; 294: 157-160.
15. 15. Barnes P J. Neurogenic Inflammation in airways and its modulation. Arch Int Pharmacodyn 1990; 303: 67-82.
16. 16. Ray N J, Jones A J, Keen P. Morphine, but not sodium cromoglycate, modulates the release of substance P from capsaicin-sensitive neurones in the rat trachea in vitro, Br J Pharmacol 1991; 102: 797-800.
17. 17. Suarez-Roca H, Abdullah L, Zuniga J, Madison S, Maixner W. Multiphasic effect of morphine on the release of substance P from rat trigeminal nucleus slices. Brain Res 1992; 579: 187-194.
18. 18. Mauborgne A, Lutz O, Legrand J-C, Hamon M, Cesselin F. Opposite effects of δ and μ opioid receptor agonists on the in vitro release of substance P-like material from the rat spinal cord. J Neurochem 1987; 48: 529-537.
19. 19. Shen K-F, Crain S M. Dual opioid modulation of the action potential duration of mouse dorsal root ganglion neurons in culture. Brain Res 1989; 491: 227-242.
20. 20. Lilly C M, Bai T R, Shore S A, Hall A E, Drazen J M. Neuropeptide content of lungs from asthmatic and nonasthmatic patients. Am J Respir Crit Care Med 1995; 151: 548-553.
21. 21. Lundberg J M, Brodin E, Rosell S, Folkers K. A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in guinea-pig. Proc Natl Acad Sci 1983; 80: 1120-1124.
22. 22. Otsuka M, Konishi S. Release of substance P-like immunoreactivity from isolated spinal cord of newborn rat. Nature (Lond.) 1976; 264: 83-84.
23. 23. Schenker C, Mroz E A, Leeman S E. Release of substance P from isolated nerve endings. Nature (Lond.) 1976; 264: 790-794.
24. 24. Takemori A E, Ikeda M, Portoghese P S. The mu, kappa and delta properties of various opioid agonists. Eur J Pharmacol 1986; 123: 357-361.
25. 25. Suarez-Roca H, Maixner W. Morphine produces a multiphasic effect on the release of substance P from rat trigeminal nucleus slices by activating different opioid receptor subtypes. Brain Res 1992; 579: 195-203.
26. 26. Barke K E, Hough L B. Opiates, mast cells and histamine release. Life Sci 1993; 53: 1391-1399.
27. 27. Saria A, Martling C R, Yan Z, Theodorsson-Norheim E, Gamse R, Lundberg J M. Release of multiple tachykinins from capsaicin-sensitive sensory nerves in the lung by bradykinin, histamine, dimethylphenyl piperazinium, and vagal nerve stimulation. Am Rev Respir Dis 1988; 137: 1330-1335.
28. 28. Collin E D, Frechilla D, Pohl M, Bourgoin S, LeBars D, Hamon M, Cesselin F. Opioid control of the release of calcitonin gene-related peptide-like material from the rat spinal cord in vivo. Brain Res 1993; 609: 211-212.
29. 29. Manaka H, Manaka Y, Kostolanska F, Fox J E, Daniel E E. Release of VIP and substance P from isolated perfused canine ileum. Am J Physiol 1989; 257: G182-G190.
30. 30. Xu H, Smolens I, Gintzler A R. Opioids can enhance and inhibit the electrically evoked release of methionine-enkephalin. Brain Res 1989; 504: 36-42.