The novel structural protein of human cytomegalovirus, pUL25, is localized in the viral tegument

Journal of Virology

Volumn 73, Issue 7, 1999, Pages 6073-6075

  Zini, N ^a   Battista, M C ^b   Santi, S ^a   Riccio, M ^a   Bergamini, G ^b   Landini, M P ^b   Maraldi, N M ^a  

^a CNR   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS PROTEIN;

ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENSE BODY; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; IMMUNOELECTRON MICROSCOPY; INTEGUMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; VIRION; VIRUS ASSEMBLY; VIRUS NUCLEOCAPSID; VIRUS REPLICATION;

EID: 0033056698     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.7.6073-6075.1999     Document Type: Article

References (17)

1. Baldick, C. J., Jr., and T. Shenk. 1996. Proteins associated with purified human cytomegalovirus particles. J. Virol. 70:6097-6105.
2. Battista, M. C., G. Bergamini, M. C. Boccuni, F. Campanini, A. Ripalti, and M. P. Landini. 1999. Expression and characterization of a novel structural protein of human cytomegalovirus, pUL25. J. Virol. 73:3800-3809.
3. Bogner, E., M. Reschke, B. Reis, T. Mockenhaupt, and K. Radsak. 1993. Identification of the gene product encoded by ORF UL56 of the human cytomegalovirus genome. Virology 196:290-293.
4. Dallas, P. B., P. A. Lyons, J. B. Hudson, A. A. Scalzo, and G. R. Shellam. 1994. Identification and characterization of a murine cytomegalovirus gene with homology to the UL25 open reading frame of human cytomegalovirus. Virology 200:643-650.
5. Gibson, W. 1996. Structure and assembly of the virion. Intervirology 39:389-400.
6. Hensel, G., H. Meyer, S. Gartner, G. Brand, and H. F. Kern. 1995. Nuclear localization of the human cytomegalovirus tegument protein pp150 (ppUL32). J. Gen. Virol. 76:1591-1601.
7. Irmiere, A., and W. Gibson. 1983. Isolation and characterization of a non-infectious virion-like particle released from cells infected with human strains of cytomegalovirus. Virology 130:118-133.
8. Landini, M. P., B. Severi, G. Furiini, and L. Badiali-De Giorgi. 1987. Human cytomegalovirus structural components: intracellular and intraviral localization of p28 and p65-69 by immunoelectron microscopy. Virus Res. 8:15-23.
9. Liu, B., and M. F. Stinski. 1992. Human cytomegalovirus contains a tegument protein that enhances transcription from promoters with upstream ATF and AP-1 cis-acting elements. J. Virol. 66:4434-4444.
10. Meyer, H., A. T. Bankier, M. P. Landini, C. M. Brown, B. G. Barrell, B. Rüger, and M. Mach. 1988. Identification and procaryotic expression of the gene coding for the highly immunogenic 28-kilodalton structural phosphoprotein (pp28) of human cytomegalovirus. J. Virol. 62:2243-2250.
11. Sanchez, V., P. C. Angeletti, J. A. Engler, and W. J. Britt. 1998. Localization of human cytomegalovirus structural proteins to the nuclear matrix of infected human fibroblasts. J. Virol. 72:3321-3329.
12. Schmolke, S., P. Drescher, G. Jahn, and B. Plachter. 1995. Nuclear targeting of the tegument protein pp65 (UL83) of human cytomegalovirus: an unusual bipartite nuclear localization signal functions with other portions of the protein to mediate its efficient nuclear transport. J. Virol. 69:1071-1078.
13. Severi, B., M. P. Landini, G. Cenacchi, N. Zini, and N. M. Maraidi. 1992. Human cytomegalovirus nuclear and cytoplasmic dense bodies. Arch. Virol. 123:193-207.
14. Spaete, R. R., R. C. Gehrz, and M. P. Landini. 1994. Human cytomegalovirus structural proteins. J. Gen. Virol. 75:3287-3308.
15. Stefan, A., P. Secchiero, T. Baechi, W. Kempf, and G. Campadelli-Fiume. 1997. The 85-kilodalton phosphoprotein (pp85) of human herpesvirus 7 is encoded by open reading frame U14 and localizes to a tegument substructure in virion particles. J. Virol. 71:5758-5763.
16. Tooze, J., M. Hollinshead, B. Reis, K. Radsak, and H. Kern. 1992. Progeny vaccinia and human cytomegalovirus particles utilize early endosomal cisternae for their envelopes. Eur. J. Cell Biol. 60:163-178.
17. Winkler, M., and T. Stamminger. 1996. A specific subform of the human cytomegalovirus transactivator protein pUL69 is contained within the tegument of virus particles. J. Virol. 70:8984-8987.