Interstitial fibrosis of unilateral ureteral obstruction is exacerbated in kidneys of mice lacking the gene for inducible nitric oxide synthase

Laboratory Investigation

Volumn 80, Issue 11, 2000, Pages 1721-1728

  Hochberg, David ^a   Johnson, Christopher W ^a   Chen, Jie ^a   Cohen, Drorit ^a   Stern, Joshua ^a   Vaughan, E Darracott ^a   Poppas, Dix ^a   Felsen, Diane ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; HYDROXYPROLINE; NITRIC OXIDE SYNTHASE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE EXACERBATION; GENE DELETION; KIDNEY FIBROSIS; KIDNEY INTERSTITIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; URETER OBSTRUCTION;

ANIMALS; KIDNEY; MICE; MICE, KNOCKOUT; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; POLYMERASE CHAIN REACTION; URETERAL OBSTRUCTION;

EID: 0033747688     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3780182     Document Type: Article

References (46)

1. Leukocyte adhesion induced by inhibition of nitric oxide production in skeletal muscle
2. Paradoxical roles of different nitric oxide synthase isoforms in colonic injury
3. Nitric oxide 9 years on
4. Transforming growth factor beta in tissue fibrosis
5. Mechanism of inducible nitric oxide synthase inactivation by aminoguanidine and L-N6-(1-iminoethyl)lysine
6. Pharmacological modulation of nitric oxide synthesis by mechanism-based inactivators and related inhibitors
7. Hypertensive nephrosclerosis in the Dahl/Rapp rat: Initial sites of injury and effect of dietary L-arginine supplementation
8. Arginine feeding modifies cyclosporine nephrotoxicity in rats
9. Macrophages, monocyte chemoattractant peptide-1, and TGF-beta 1 in experimental hydronephrosis
10. Molecular insights into renal interstitial fibrosis
11. Antigen markers of macrophage differentiation in murine tissues
12. Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock
13. Angiotensin II-induced cardiac fibrosis in the rat is increased by chronic inhibition of nitric oxide synthase
14. The role of nitric oxide in obstructive nephropathy
15. Angiotensin II receptor antagonist ameliorates renal tubulointerstitial fibrosis caused by unilateral ureteral obstruction
16. Nitric oxide is an antiadhesive molecule for leukocytes
17. Dietary supplementation with L-arginine ameliorates glomerular hypertension in rats with subtotal nephrectomy
18. MR findings in diffuse renal parenchymal disease
19. Nitric oxide as a bifunctional regulator of apoptosis
20. The role of growth factors, cytokines, and vasoactive compounds in obstructive nephropathy
21. Nitric oxide in renal health and disease
22. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
23. Lessons from genetically engineered animal models. IV. Nitric oxide synthase gene knockout mice
24. Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry
25. Antibody to TGF-β ameliorates tubular apoptosis in unilateral ureteral obstruction
26. Role of nitric oxide in renal tubular apoptosis of unilateral ureteral obstruction
27. L-N6-(1-iminoethyl)lysine: A selective inhibitor of inducible nitric oxide synthase
28. Nitric oxide generation ameliorates the tubulointerstitial fibrosis of obstructive nephropathy
29. Chronic inhibition of nitric oxide synthesis causes coronary microvascular remodeling in rats
30. L-arginine supplementation increases mesangial cell injury and subsequent tissue fibrosis in experimental glomerulonephritis
31. Angiotensin II blockade and low-protein diet produce additive therapeutic effects in experimental glomerulonephritis
32. Susceptibility of mice with specific NOS gene deletions to experimental colitis
33. A simplified method for the analysis of hydroxyproline in biological tissues
34. L-arginine administration prevents glomerular hyperfiltration and decreases proteinuria in diabetic rats
35. Low plasma and renal tissue levels of L-arginine in rats with obstructive nephropathy
36. EDRF role in renal function and blood pressure of normal rats and rats with obstructive uropathy
37. BCL-2 and p53 expression in clinically localized prostate cancer predicts response to external beam radiotherapy
38. The nitric oxide system is activated during late unilateral ureteral obstruction
39. Interstitial fibrosis in obstructive nephropathy
40. Angiotensin II-induced myocardial fibrosis in rats: Role of nitric oxide, prostaglandins and bradykinin
41. Early induction of transforming growth factor-beta via angiotensin II type 1 receptors contributes to cardiac fibrosis induced by long-term blockade of nitric oxide synthesis in rats
42. Nitric oxide stimulates the activity of a 72-kDa neutral matrix metalloproteinase in cultured rat mesangial cells
43. Chronic unilateral ureteral obstruction is associated with interstitial fibrosis and tubular expression of transforming growth factor-beta
44. Nitric oxide modulates the expression of monocyte chemoattractant protein 1 in cultured human endothelial cells
45. Amlodipine enhances NO production induced by an ACE inhibitor through a kinin-mediated mechanism in canine coronary microvessels