Structure of a novel extracellular Ca2+-binding module in BM-40

Nature Structural Biology

Volumn 3, Issue 1, 1996, Pages 67-73

  Hohenester, Erhard ^a   Maurer, Patrik ^b   Hohenadl, Christine ^b   Timpl, Rupert ^b   Jansonius, Johan N ^a   Engel, Jürgen ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALMODULIN; OSTEONECTIN; SCLEROPROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CALCIUM BINDING; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; EXTRACELLULAR MATRIX; PRIORITY JOURNAL; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; BINDING SITES; CALCIUM; CALCIUM-BINDING PROTEINS; CRYSTALLOGRAPHY, X-RAY; HUMANS; MOLECULAR SEQUENCE DATA; OSTEONECTIN; PROTEIN CONFORMATION;

EID: 0030040724     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb0196-67     Document Type: Article

References (13)

1. Nakayama, S. & Kretsinger, R.H. Evolution of the EF-hand family of proteins. Annu. Rev. Biophys. biomolec. Struct. 23, 473-507 (1994).
2. Kretsinger, R.H., Tolbert, D., Nakayama, S. & Pearson, W. The EF-hand. homologs and analogs. In Novel calcium binding proteins (ed Heizmann, C.W.) 17-37 (Springer, Berlin, 1991).
3. Strynadka, N.C.J. & James, M.N.G. Crystal structures of the helix-loophelix calcium-binding proteins. A. Rev. Biochem. 58, 951-998 (1989).
4. McPhalen, C.A., Strynadka, N.C.J. & James, M.N.G. Calcium-binding sites in proteins: a structural perspective. Adv. Prot. Chem. 42, 77-144 (1991).
5. Kretsinger, R.H. & Nockolds, C.E. Carp muscle calcium-binding protein: structure determination and general description. J biol. Chem. 9, 3313-3326 (1973).
6. Finn, B.E. & Forsén, S. The evolving model of calmodulin structure, function and activation. Structure 3, 7-11 (1995).
7. Crivici, A. & Ikura, M. Molecular and structural basis of target recognition by calmodulin. A. Rev. Biophys. biomol. Struct. 24, 85-116 (1995).
8. Falke, J.J., Drake, S.K., Hazard, A.L. & Peersen, O.B. Molecular tuning of ion binding to calcium signaling proteins. Quart. Rev. Biophys. 27, 219-290 (1994).
9. Engel. J., Taylor. W., Paulsson, M., Sage, H. & Hogan, B. Calciumbinding domains and calcium-induced conformational transition of SPARC/BM-40/osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues. Biochemistry 26, 6958-6965 (1987).
10. Bolander, M.E., Young, M.F., Fisher, L.W., Yamada, Y. & Termine, J.D. Osteonectin cDNA sequence reveals potential binding regions for calcium and hydroxyapatite and shows homologies with both a basement membrane protein (SPARC) and a serine protease inhibitor (ovomucoid). Prac. natn. Acad. Sci. U.S.A. 85, 2919-2923 (1988).
11. Pottgieser, J. et al. Changes in calcium and collagen IV binding caused by mutations in the EF hand and other domains of extracellular matrix protein BM-40 (SPARC, osteonectin). J. molec. Biol. 238, 563-574 (1994).
12. Termine, J.D. et al. Osteonectin, a bone-specific protein linking mineral to collagen. Cell 26, 99-105 (1981).
13. r 43 000. EMBOJ. 5, 1465-1472 (1986).