The mechanism of geranylgeraniol-induced apoptosis involves activation, by a caspase-3-like protease, of a c-Jun N-terminal kinase signaling cascade and differs from mechanisms of apoptosis induced by conventional chemotherapeutic drugs

Leukemia Research

Volumn 24, Issue 11, 2000, Pages 937-950

  Masuda, Yutaka ^a   Nakaya, Mie ^a   Aiuchi, Toshihiro ^a   Hashimoto, Sachiko ^a   Nakajo, Shigeo ^a   Nakaya, Kazuyasu ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Caspase; Geranylgeraniol; JNK; Leukemia cells

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CHLOROBENZENE; GERANYLGERANIOL; GREEN FLUORESCENT PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASES; CYSTEINE PROTEINASE INHIBITORS; DITERPENES; GREEN FLUORESCENT PROTEINS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; K562 CELLS; LUMINESCENT PROTEINS; MAP KINASE KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MUTAGENESIS; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; SEQUENCE DELETION; TRANSFECTION; U937 CELLS;

EID: 0033730298     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(00)00066-7     Document Type: Article

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