Positive and negative regulation of IL-12 receptor expression of naive CD4+ T cells by CD28/CD152 co-stimulation

European Journal of Immunology

Volumn 30, Issue 11, 2000, Pages 3171-3180

  Yamane, Hidehiro ^a,b   Igarashi, Osamu ^a   Kato, Takuma ^a,d   Nariuchi, Hideo ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c Ogata Institute for Medical and Chemical Research   (Japan)

^d MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

CD28 CD152; IFN ; IFN R; IL 12R; Naive CD4+ T cell

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD86 ANTIGEN; CELL ANTIGEN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 2; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; FEMALE; GENETIC TRANSFECTION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION; CD4-POSITIVE T-LYMPHOCYTES; CHO CELLS; CRICETINAE; GENE EXPRESSION REGULATION; IMMUNOCONJUGATES; LIGANDS; MICE; MICE, INBRED C57BL; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; SIGNAL TRANSDUCTION;

EID: 0033729633     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200011)30:11<3171::AID-IMMU3171>3.0.CO;2-C     Document Type: Article

References (43)

1. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
2. Second signal activity of IL-12 on the proliferation and IL-2R expression of T helper cell-1 clone
3. Induction of IL-12 p40 messenger RNA expression and IL-12 production of macrophages via CD40-CD40 ligand interaction
4. Effective stimulation for IL-12 p35 mRNA accumulation and bioactive IL-12 production of antigen-presenting cells interacted with Th cells
5. + T cells through IL-12 produced by Listeria-induced macrophages
6. + T cells
7. CD28/B7 interactions delivers a unique signal to naive T ceils that regulates cell survival but not early proliferation
8. CD28 activation pathway regulates the production of multiple T cell derived lymphokines/cytokines
9. Regulation of lymphokine mRNA stability by a surface-mediated activation pathway
10. Role of co-stimulation of the IL-12/IL-12R receptor pathway and the development of autoimmunity
11. TCR-independent pathways mediate the effects of antigen dose and altered peptide ligands on Th cell polarization
12. CTLA-4 can function as a negative regulator of T cell activation
13. CD28 and CTLA-4 have opposing effects on the response of T cell activation
14. + T cells
15. Role of transforming growth factor-β in the preferential induction of T helper cells of type 1 by staphylococcal enterotoxin B
16. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
17. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses
18. CD28 co-stimulation promotes the production of Th2 cytokines
19. B7 and interleukin 12 cooperate for proliferation and interferon-γ production by mouse T helper clones that are unresponsive to B7 co-stimulation
20. B7-1 synergizes with interleukin-12 in interleukin-2 receptor α expression by mouse T helper 1 clones
21. + T cells by co-stimulation with B7-2 molecules
22. Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells
23. Ligand-induced autoregulation of IFN-γ receptor β chain expression in T helper subsets
24. Regulation of surface and intracellular expression of CTLA-4 on mouse T cells
25. Cytokine regulation of IL-12 receptor β2 expression: Differentiatial effects on human T and NK cells
26. Interleukin-2 enhances the response of natural killer cells to interleukin-12 through upregulation of the interleukin-12 receptor and STAT4
27. CD28 co-stimulatory signals induce IL-2 receptor expression on antigen-stimulated virgin T cells by an IL-2-independent mechanism
28. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
29. Interleukin 2 upregulates expression of its receptor on a T cell clone
30. Regulation of interleukin (IL)-12 receptor β2 subunit expression by endogenous IL-12: A critical step in the differentiation of pathogenic autoreactive T cells
31. Ligation of B7 with CD28/ CTLA-4 on T cells results in CD40 ligand expression, interleukin-4 secretion and efficient help for antibody production by B cells
32. + cells
33. The role of CTLA-4 in regulating Th2 differentiation
34. Limited role of CD28-mediated signals in T helper subset differentiation
35. CD28 dependence oft cell differentiation to IL-4 production varies with the particular type 2 immune response
36. + T cell responses: The alternative approaches
37. Intracellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells
38. LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production
39. Suppression of concanavalin A-induced hepatitis in IFN-γ(-/-), but not in TNF-α(-/-), mice: Role for IFN-γ in activating apoptosis of hepatocytes
40. T cell activation through TCR-CD3 complex: IL-2 production of T cell clones stimulated with anti-CD3 without cross-linkage
41. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4, or 5, using modified cDNA expression vectors
42. Costimulatory effect of IL-12 on the activation of naive, memory CD4+ T cells and Th1 clone
43. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction