A monoclonal antibody directed against the neurokinin-1 receptor contains a peptide sequence with similar hydropathy and functional properties to substance P, the natural ligand for the receptor

Molecular Immunology

Volumn 37, Issue 8, 2000, Pages 423-433

  Sagot, Marie Astrid ^a   Wijkhuisen, Anne ^a,b   Créminon, Christophe ^a   Tymciu, Sylvie ^a   Frobert, Yveline ^a   Turbica, Isabelle ^a,b   Grassi, Jacques ^a   Couraud, Jean Yves ^a,b   Boquet, Didier ^a  

^a DIF   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Complementary peptide; Hydropathic homology; Molecular mimicry; NKI receptor; Substance P

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; INOSITOL PHOSPHATE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY PS12; NEUROKININ 1 RECEPTOR; SUBSTANCE P; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ANTIBODY STRUCTURE; ANTIGEN ANTIBODY REACTION; ARTICLE; COMPLEMENTARITY DETERMINING REGION; MOLECULAR CLONING; MOLECULAR MIMICRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS; CHO CELLS; CRICETINAE; HUMANS; HYBRIDOMAS; IMMUNOGLOBULIN VARIABLE REGION; INOSITOL PHOSPHATES; LIGANDS; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; RECEPTORS, NEUROKININ-1; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SUBSTANCE P;

EID: 0033711993     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(00)00060-2     Document Type: Article

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