Metabolic activation of o-phenylphenol to a major cytotoxic metabolite, phenylhydroquinone: Role of human CYP1A2 and rat CYP2C11/CYP2E1

Xenobiotica

Volumn 30, Issue 10, 2000, Pages 1005-1017

  Ohno, Y ^a   Ozawa, S ^a   Ohta, K ^a   Miyajima, A ^a   Kurebayashi, H ^a   Sunouchi, M ^a   Shimizy, M ^a   Murayama, N ^a,b   Matsumoto, Y ^b   Fukuoka, M ^b  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA NAPHTHOFLAVONE; CHLORZOXAZONE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C11; DIMETHYLNITROSAMINE DEMETHYLASE; FURAFYLLINE; HYDROXYBIPHENYL; ISONIAZID; PHENYLHYDROQUINONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROXYLATION; IN VITRO STUDY; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; RAT;

ANIMALIA; MAMMALIA; UNIDENTIFIED BACULOVIRUS;

EID: 0033711983     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/00498250050200159     Document Type: Article

References (27)

1. Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites
2. Oxygen and xenobiotic reductase activities of cytochrome P450
3. The effect of phenobarbital and β-naphthoflavone induction on the metabolism of biphenyl in the rat and mouse
4. Sex difference in o-phenylphenate rat urinary bladder carcinogenesis: Urinary metabolites and electrolytes under conditions of aciduria and alkaliuria
5. Induction of tumours of the urinary system in F344 rats by dietary administration of sodium o-phenylphenate
6. Toxicological studies of orthophenylphenol (Dowcide 1)
7. First-phase inter-laboratory validation of the in vitro eye irritation tests for cosmetic ingredients. X-Evaluation of cytotoxicity tests on SIRC cells
8. Genotoxic effects of the o-phenylphenol metabolites phenylhydroquinone and phenylbenzoquinone in V79 cells
9. Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: Implications for active site modelling
10. The effect of orthophenylphenol, tris(2,3-dichloroporpyl)phosphate, and cyclophosphamide on the immune system and host susceptibility of mice following subchronic exposure
11. Polymorphic metabolism of the carcinogen 2-acetylaminofluorene in human liver microsomes
12. DNA damage in urinary bladder epithelium of male F344 rats treated with 2-phenyl-1,4-benzoquinone, one of the non-conjugated urinary metabolites of sodium o-phenylphenate
13. Correlation between the DNA damage in urinary bladder epithelium and the urinary 2-phenyl-1,4-benzoquinone levels from F344 rats fed sodium o-phenylphenate in the diet
14. Oxidative damage to cellular and isolated DNA by metabolites of a fungecide ortho-phenylphenol
15. DNA cleavage by phenylhydroquinone: The major metabolite of a fungicide o-phenylphenol
16. Formation of 8-hydroxydeoxyguanosine in calf thymus DNA treated in vitro with phenylhydroquinone, the major metabolite of o-phenylphenol
17. Activation of phenacetin o-deethylase activity by α-naphthoflavone in human liver microsomes
18. Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: Absence of mutation prescribing the phenotype in the CYP1A2 gene
19. Alternative methods for mechanistic studies in toxicology. Screening of hepatotoxicity of pesticides using freshly isolated and primary cultured hepatocytes and non-liver-derived cells, SIRC cells
20. Specificity of substrate and inhibitor probes for cytochrome P450s: Evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes
21. Monoclonal antibodies of differentiating specificities as probes of cytochrome P450h (2C11)
22. In vivo genotoxicity of ortho- phenylphenol, biphenyl, and thiabendazole detected in multiple mouse organs by the alkaline single cell gel electrophoresis assay
23. Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal livers and adult lungs
24. Cytotoxicity of food preservatives in cultured rat hepatocytes loaded with linolenic acid
25. Effect of scavengers of active oxygen species on cell damage caused in CHO-K1 cells by phenylhydroquinone, an o-phenylphenol metabolite
26. Examination of metabolic pathways and identification of human liver cytochrome P450 isozymes responsible for the metabolism of barnidipine, a calcium channel blocker
27. DNA adduct formation by o-phenylphenol metabolite in vivo and in vitro