A-ZIP/F-1 mice lacking white fat: A model for understanding lipoatrophic diabetes

International Journal of Obesity

Volumn 24, Issue , 2000, Pages S11-S14

  Reitman, M L ^a   Gavrilova, O ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Adipose tissue; Diabetes; Fasting; Insulin resistance; Leptin; Lipoatrophy lipodystrophy; Torpor

Indexed keywords

LEPTIN;

ADAPTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; ENERGY METABOLISM; HIBERNATION; INSULIN RESISTANCE; LIPOATROPHIC DIABETES MELLITUS; LIPOATROPHY; LIPODYSTROPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; ANIMALS; BODY COMPOSITION; DIABETES MELLITUS, LIPOATROPHIC; DISEASE MODELS, ANIMAL; FASTING; HUMANS; INSULIN RESISTANCE; LEPTIN; MICE; MICE, TRANSGENIC; PHENOTYPE; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0033711146     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/sj.ijo.0801493     Document Type: Article

References (19)

1. Foster DW. The lipodystrophies and other rare disorders of adipose tissue. In: Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL (eds). Harrison’s Principles of Internal Medicine. McGraw-Hill: New York, 1998, pp 2209-2214.
2. Seip M, Trygstad O. Generalized lipodystrophy, congenital and acquired (lipoatrophy). Acta Paediatr Suppl 1996; 413: 2-28.
3. Rossini AA, Cahill GFJ. Lipoatrophic diabetes. In: DeGroot LJ, Cahill GF Jr, Martini L, Nelson DH, Odell WD, Potts JT, Jr, E Steinberger E, Winegrad AI (eds). Endocrinology. Grune & Stratton: New York, 1979, pp 1093-1097.
4. Vigouroux C, Khallouf E, Bourut C, Robert JJ, de Kerdanet M, Tubiana-Rufi N, Faure S, Weissenbach J, Capeau J, Magre J. Genetic exclusion of 14 candidate genes in lipoatropic diabetes using linkage analysis in 10 consanguineous families. J Clin Endocrinol Metab 1997; 82: 3438-3444.
5. Cao H, Hegele RA. Nuclear lamin A/C R482Q mutation in Canadian kindreds with Dunnigan-type familial partial lipo-dystrophy. Hum Mol Genet 2000; 9: 109-112.
6. Shackleton S, Lloyd DJ, Jackson SN, Evans R, Niermeijer MF, Singh BM, Schmidt H, Brabant G, Kumar S, Durrington PN, Gregory S, O’Rahilly S, Trembath RC. LMNA, encoding lamin A/C, is mutated in partial lipodystrophy. Nature Genet 2000; 24: 153-156.
7. Garg A, Wilson R, Barnes R, Arioglu E, Zaidi Z, Gurakan F, Kocak N, O’Rahilly S, Taylor SI, Patel SB, Bowcock AM. A gene for congenital generalized lipodystrophy maps to human chromosome 9q34. J Clin Endocrinol Metab 1999; 84: 3390-3394.
8. Moitra J, Mason MM, Olive M, Krylov D, Gavrilova O, Marcus-Samuels B, Feigenbaum L, Lee E, Aoyama T, Eckhaus M, Reitman ML, Vinson C. Life without white fat: a transgenic mouse. Genes Devl 1998; 12: 3168-3181.
9. Ross SR, Graves RA, Spiegelman BM. Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity. Genes Devl 1993; 7: 1318-1324.
10. Burant CF, Sreenan S, Hirano K, Ta TA, Lohmiller J, Lukens J, Davidson NO, Ross S, Graves RA. Troglitazone action is independent of adipose tissue. J Clin Invest 1997; 100: 2900-2908.
11. Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bash-makov Y, Goldstein JL, Brown MS. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Devl 1998; 12: 3182-3194.
12. Gavrilova O, Leon LR, Marcus-Samuels B, Mason MM, Castle AL, Refetoff S, Vinson C, Reitman ML. Torpor in mice is induced by both leptin-dependent and-independent mechanisms. Proc Natl Acad Sci USA 1999; 96: 14623-14628.
13. Gavrilova O, Marcus-Samuels B, Graham D, Kim JK, Shul-man GI, Castle AL, Vinson C, Eckhaus M, Reitman ML. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J Clin Invest 2000; 105: 271-278.
14. Kim JK, Gavrilova O, Chen Y, Reitman ML, Shulman GI. Mechanism of insulin resistance in A-ZIP/F-1 fatless mice. J Biol Chem 2000; 275: 8456-8460.
15. Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron MJ. Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 1997; 389: 374-377.
16. Rossetti L, Massillon D, Barzilai N, Vuguin P, Chen W, Hawkins M, Wu J, Wang J. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem 1997; 272: 27758-27763.
17. Shimomura I, Hammer RE, Ikemoto S, Brown MS, Goldstein JL. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 1999; 401: 73-76.
18. Gavrilova O, Marcus-Samuels B, Leon LR, Vinson C, Reit-man ML. Leptin and diabetes in lipoatrophic mice. Nature 2000; 403: 850.
19. Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, Shen J, Vinson C, Rueger JM, Karsenty G. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 2000; 100: 197-207.