Molecular strategies to define HLA haplotype loss in microdissected tumor cells

Human Immunology

Volumn 61, Issue 10, 2000, Pages 1001-1012

  Ramal, Luis Manuel ^a   Maleno, Isabel ^a   Cabrera, Teresa ^a   Collado, Antonia ^b   Ferron, Antonio ^b   Lopez Nevot, Miguel Angel ^a   Garrido, Federico ^a,b  

^a Department of Analisis Clinicos ^*  (Spain)

^b HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

Author keywords

2 microglobulin; Expression; HLA; LOH; Tumor

Indexed keywords

BETA 2 MICROGLOBULIN; HLA ANTIGEN; HLA ANTIGEN CLASS 1;

ALLELE; ANTIGEN EXPRESSION; ARTICLE; CELLULAR IMMUNITY; CHROMOSOME 15; CHROMOSOME 6P; CLINICAL ARTICLE; COLORECTAL CARCINOMA; CRYOPRESERVATION; GENE AMPLIFICATION; HAPLOTYPE; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LARYNX CARCINOMA; PRIORITY JOURNAL; TUMOR CELL;

BETA 2-MICROGLOBULIN; COLORECTAL NEOPLASMS; CRYOPRESERVATION; HAPLOTYPES; HISTOCOMPATIBILITY TESTING; HISTOLOGICAL TECHNIQUES; HLA ANTIGENS; HUMANS; LARYNGEAL NEOPLASMS; LOSS OF HETEROZYGOSITY; LYMPHOCYTES; MICROSATELLITE REPEATS; PHENOTYPE;

EID: 0033695531     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(00)00171-3     Document Type: Article

References (26)

1. Natural history of HLA expression during tumour development
2. The biological consequences of altered MHC expression on tumors
3. Implications for immunosurveillance of altered HLA class I phenotypes in human tumors
4. 2-microglobulin gene result in a lack of HLA class I molecules on melanoma cells of two patients immunized with MAGE peptides
5. Chromosome loss is the most frequent mechanism contributing to HLA haplotype loss in human tumors
6. HLA class I expression and chromosomal deletions at 6p and 15q in head and neck squamous cell carcinomas
7. HLA class I phenotype and genotype alterations in cervical carcinomas and derivate cell lines
8. Criteria to define HLA haplotype loss in human solid tumors
9. Microsatellite analysis of micro-dissected tumor cells and 6p high density microsatellite analysis in HHSCC with downregulated HLA class I expression
10. HLA-A typing: Comparison between serology, the amplification refractory mutation system with polymerase chain reaction and sequencing
11. HLA-B locus sequence-based typing
12. HLA class II region sequences
13. HLA class I region sequences
14. High frequency of altered HLA class I phenotypes in invasive breast carcinomas
15. HLA and cancer
16. Practical histological microdissection for PCR analysis
17. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma
18. HLA class I antigens in human tumors
19. The HLA crossroad in tumor immunology
20. A simple method for PCR based analyses of immunohistochemically stained, microdissected, formalin fixed, paraffin wax embedded material
21. Loss of heterozygosity on 8p in prostate cancer implicates a role for dematin in tumor progression
22. Loss of heterozygosity on chromosome 13 is associated with advanced stage prostate cancer
23. Frequent loss of heterozygosity on chromosome 6p in uveal melanoma
24. Multiple genetic alterations cause frequent and heterogeneous human histocompatibility leukocyte antigen class I loss in cervical cancer
25. Human leukocyte antigens class I gene mutations in cervical cancer
26. New polymorphic microsatellite markers in the human MHC class I region