Adenovirus-mediated expression of antisense RNA transcripts complementary to pig α(1,3) galactosyltransferase mRNA inhibits expression of Gal α(1,3) Gal epitope

Acta Pharmacologica Sinica

Volumn 21, Issue 11, 2000, Pages 1005-1010

  Xing, L ^a   Xia, G H ^a   Bai, X F ^a   Fei, J ^a   Guo, L H ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Antisense RNA; Epitopes; Fucosyltransferases; Galactosyltransferases; Gene expression; Human adenoviruses

Indexed keywords

COMPLEMENTARY RNA; EPITOPE; FUCOSYLTRANSFERASE; GALACTOSYLTRANSFERASE; MESSENGER RNA; VIRUS VECTOR;

ADENOVIRUS; ANTIGEN EXPRESSION; ARTICLE; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS RECOMBINANT;

3T3 CELLS; ADENOVIRUSES, HUMAN; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE; DISACCHARIDES; DOWN-REGULATION; EMBRYO; FUCOSYLTRANSFERASES; GALACTOSYLTRANSFERASES; GENE EXPRESSION; HUMANS; KIDNEY; LIVER NEOPLASMS; MICE; RNA, ANTISENSE; RNA, MESSENGER; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033694756     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Xenoantigens and xenoantibodies
2. Adenovirus-mediated gone transfer of antisense ribozyme for α(1,3) galactosyltransferase gene and α (1,2) fucosyltransferase gene in xenotransplantation
3. Inhibitory effect of alpha(1,2) fucosyltransferase recombinant adenoviral vector on alpha Gal expression
4. Adenovirus-mediated expression of human secretor type α(1,2) fucosyltransferase reduces level of Gal α(1,3) Gal epitope
5. cDNA sequence and chromosome localization of pig α(1,3) galactosyltransferase
6. A simple technique for the rescue of early region 1 mutations into infectious human Adenovirus type 5
7. Techniques for human adenovirus vector construction and characterization
8. Reduction in the level of Gal α(1,3) Gal in transgenic mice and pigs by the expression of an α(1,2) fucosyltransferase
9. A unique mechanism regulating gene expression: Translational inhibition by a complementary RNA transcript
10. Antisense RNA inhibition of endogenous genes
11. Murine alpha-1, 3-galactosyltransferase: A single gene locus specifies four isoforms of the enzyme by alternative splicing
12. Sensitization of cells and retroviruses to human serum by (αl - 3) galactosyltransferase