Adenovirus-mediated expression of human secretor type α(1, 2) fucosyltransferase reduces level of Ga1α (1,3) Gal epitop

Acta Pharmacologica Sinica

Volumn 21, Issue 9, 2000, Pages 807-813

  Xing, L ^a   Xia, G H ^a   Fei, J ^a   Bai, X F ^a   Guo, L H ^a  

^a Chinese Academy of Scieces   (China)

Author keywords

Antigens; Epitopes; Fucosyltransferases; Gene expression; Human adenoviruses

Indexed keywords

BLOOD GROUP ANTIGEN; EPITOPE; FUCOSYLTRANSFERASE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY;

ANIMAL CELL; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; CELL CULTURE; CELL STRAIN 3T3; CELL SURFACE; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; FLUORESCENCE; GENE EXPRESSION; HUMAN ADENOVIRUS; INFECTION; LYSIS; MOUSE; NONHUMAN; VIRUS VECTOR;

3T3 CELLS; ADENOVIRUSES, HUMAN; ANIMAL; CELL LINE; CHO CELLS; DISACCHARIDES; EMBRYO; FUCOSYLTRANSFERASES; HAMSTERS; HUMAN; KIDNEY; MICE; SUPPORT, NON-U.S. GOV'T; TRANSFECTION;

EID: 0033804961     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Transplantation of discordant xenografts: A challenge revisited
2. The α-1,3-galactosyltransferase knockout mouse: Implications for xenotransplantation
3. Reduction in the level of Gala(1,3) Gal in transgenic mice and pigs by the expression of an α(1,2) fucosyltransferase
4. Man, apes, and old world monkeys differ from other mammals in the expression of α-galactosyl epitopes on nucleated cells
5. Frameshift and nonsense mutations in a human genomic sequence homologous to a routine UDP-Gal: β-D-Gall, 4-D-GlcNAc α 1,3-galacrosyltransferase cDNA
6. Molecular cloning, sequence, and expression of a human GDP-L-fucose:β-D-galactoside 2-α-L-fucosyltransferase cDNA that can form the H hood group antigen
7. Sequence and expression of a candidate for the human secretor blood group a (1,2) fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype
8. Combined transgenic expression of αgalactosidase and α (1,2) fucosyltransferase leads to optimal reduction in the major xenoepitope Gale (1, 3)Gal
9. Inhibitory effect of alpha (1,2) fucosyltransferase recombinant adenoviral vector on alpha Gal expression
10. Transgenic expression of human alpha 1,2-fucosyltransferase (H-transferase) prolongs mouse heart survival in an ex vivo model of xenograft rejection
11. Expression of α1,3-galactose and other type 2 oligosaccharide structures in a porcine endothelial cell line transfected with human α(1,2) fucosyltransferase cDNA
12. A simple technique for the rescue of early region 1 mutations into infectious human adenovirus type5
13. Techniques for human adenovims vector construction and characterization
14. Characterizaton of porine platelet glycoproteins recognized by human natural 'ant-gal' antibodies
15. Large scale recovery of biologically active IgM (95 % pure) from human plasma obtained by therapeutic plasmapheresis
16. Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents
17. Evaluaton of a tetrazolium-based semiautomated colorimetric assay: Assessment of radiosensitivity
18. Expression of human h-type α 1,2 fucosyltransferase encoding for blood group H (O) antgen in Chinese Hamster Ovary cells
19. Sensitization of cells and retroviruses to human serum by (α1 - 3) galactosyltransferase
20. Changes in cell surface glycosylation in α1,3 galactosyltransferase knockout and α1, 2 fucosyltransferase transgene mice
21. Direct gene replacement of the mouse α(1,3) galactosyltransferase gene with human α(1,2) fucosyltransferase gene: Converting α-galactosyl epitopes into H antgens
22. Enzymatic remodeling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis
23. Natural anti-Gal antibody as a universal augmenter of autologous rumor vaccine immunogenicity