Efficient DNA base excision repair in ataxia telangiectasia cells

European Journal of Biochemistry

Volumn 267, Issue 23, 2000, Pages 6883-6887

  Cappelli, Enrico ^a   Rossi, Ottavio ^a   Chessa, Luciana ^b   Frosina, Guido ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Abasic sites; Ataxia telangiectasia; DNA base excision repair; In vitro; Uracil

Indexed keywords

ALKYLATING AGENT; BRCA1 PROTEIN; DNA BASE; FREE RADICAL; NUCLEOTIDE; URACIL;

ARTICLE; ATAXIA TELANGIECTASIA; CELL DIVISION; DNA REPAIR; EXCISION REPAIR; HUMAN; HUMAN CELL; IONIZING RADIATION; MUTATION; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ATAXIA; ATAXIA TELANGIECTASIA; MAMMALIA; ZIZIPHUS MAURITIANA;

EID: 0033694738     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2000.01789.x     Document Type: Article

References (39)

1. The ATM gene and protein: Possible roles in genome surveillance, checkpoint controls and cellular defence against oxidative stress
2. A single ataxia telangiectasia gene with a product similar to PI-3 kinase
3. The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species
4. Genomic organization of the ATM gene
5. Abnormal response of ataxia-telangiectasia cells to agents that break the deoxyribose moiety of DNA via a targeted free radical mechanism
6. In vitro phenotype of ataxia-telangiectasia (AT) fibroblast strains: Clues to the nature of the 'AT DNA lesion' and the molecular defect in AT
7. Response of fibroblasts cultures from ataxia-telangiectasia patients to oxidative stress
8. Response of fibroblast cultures from ataxia-telangiectasia patients to reactive oxygen species generated during inflammatory reactions
9. Hypersensitivity of ataxia telangiectasia skin fibroblasts to DNA alkylating agents
10. Generation of single nucleotide repair patches following excision of uracil residues from DNA
11. Two pathways for base excision repair in mammalian cells
12. Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA
13. DNA strand breakage repair in ataxia-telangiectasia fibroblast-like cells
14. Is chromatid-type damage in ataxia-telangiectasia after irradiation at G0 a consequence of defective repair?
15. Normal repair of DNA single-strand breaks in patients with ataxia-telangiectasia
16. Repair of strand breaks in superhelical DNA of ataxia telangiectasia lymphoblastoid cells
17. DNA replication and repair in ataxia-telangiectasia cells exposed to bleomycin
18. Dose-rate effect on induction and repair rate of radiation-induced DNA double-strand breaks in a normal and an ataxia telangiectasia human fibroblast cell line
19. Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks
20. Identification of ATM mutations using extended RT-PCR and restriction endonuclease fingerprinting, and elucidation of the repertoire of A-T mutations in Israel
21. ATM protein and p53-serine phosphorylation in AtaxiA-Telangiectasia (AT) patients and AT heterozygotes
22. Predominance of null mutations in ataxia-telangiectasia
23. In vitro base excision repair assay using mammalian cell extracts
24. Promoter-selective activation domains in October-1 and October-2 direct differential activation of an snRNA and mRNA promoter
25. Proliferating cell nuclear antigen-dependent abasic site repair in Xenopus laevis oocytes: An alternative pathway of base excision DNA repair
26. Involvement of XRCC 1 and DNA ligase III gene products in DNA base excision repair
27. Different DNA polymerases are involved in the short and long-patch base excision repair in mammalian cells
28. Comparative repair of the endogenous lesions 8-oxoguanine, uracil and abasic site by mammalian cell extracts: 8-Oxoguanine is poorly repaired by human cell extracts
29. Long patch base excision repair with purified human proteins. DNA ligase I as patch size mediator for DNA polymerases delta and epsilon
30. Splitting the ATM: Distinct repair and checkpoint defects in ataxia-telangiectasia
31. Deficient recovery from potentially lethal radiation damage in ataxia telangiectasia and xeroderma pigmentosum
32. Defective recovery from potentially lethal damage in some human fibroblast cell strains
33. On the nature of a defect in cells from individuals with ataxia-telangiectasia
34. Heterogeneity in ataxia telangiectasia: Classical phenotype associated with low cellular radiosensitivity
35. Requirement of ATM-dependent phosphorylation of Brca1 in the DNA damage response to double-strand breaks
36. BRCA1 required for transcription-coupled repair of oxidative DNA damage
37. Requirement of mammalian DNA polymerase β in base-excision repair
38. Repair by human cell extracts of single (6-4) and cyclobutane thyminethymine photoproducts in DNA
39. Protective roles for ATM in cellular response to oxidative stress