Probenecid-associated alterations in valproic acid pharmacokinetics in rats: Can in vivo disposition of valproate glucuronide be predicted from in vitro formation data?

Drug Metabolism and Disposition

Volumn 28, Issue 12, 2000, Pages 1433-1439

  Stacy Ward, E ^a   Pollack, G M ^a   Brouwer, K L R ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROBENECID; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG BILE LEVEL; DRUG DISPOSITION; DRUG EFFECT; DRUG ELIMINATION; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG PROTEIN BINDING; HEPATOBILIARY SYSTEM; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; RAT;

ALGORITHMS; ANIMALS; ANTICONVULSANTS; CYTOSOL; GLUCURONIDES; MALE; PROBENECID; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RENAL AGENTS; TISSUE DISTRIBUTION; VALPROIC ACID;

ANIMALIA;

EID: 0033675837     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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