The involvement of phospholipase C in crystal induced human neutrophil activation

Journal of Rheumatology

Volumn 27, Issue 12, 2000, Pages 2877-2885

  Jackson, J K ^a   Tudan, C ^a   Burt, H M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Calcium pyrophosphate dihydrate; Monosodium urate monohydrate; Neutrophils; Phospholipase C; U73122

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 2,5 PYRROLIDINEDIONE; CALCIUM PYROPHOSPHATE; ISOENZYME; PHOSPHOLIPASE C; SUPEROXIDE; URATE;

ARTICLE; DEGRANULATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RESPIRATORY BURST; SIGNAL TRANSDUCTION;

CALCIUM; CALCIUM PYROPHOSPHATE; CELL DEGRANULATION; CELL RESPIRATION; CHEMILUMINESCENT MEASUREMENTS; CRYSTALLIZATION; DIGLYCERIDES; DRUG INTERACTIONS; ESTRENES; HUMANS; ISOENZYMES; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHIL ACTIVATION; NEUTROPHILS; PHOSPHODIESTERASE INHIBITORS; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PYRROLIDINONES; SIGNAL TRANSDUCTION; SUPEROXIDES; URIC ACID;

EID: 0033674927     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Pathogenesis and treatment of crystal-induced inflammation
2. Mechanism of neutrophil activation by an unopsonized inflammatory particulate
3. Neutrophil activation by inflammatory microcrystals of monosodium urate monohydrate utilizes pertussis toxin-insensitive and sensitive pathways
4. Crystal-induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production by microcrystals
5. Monosodium urate and calcium pyrophosphate crystals differentially activate the excitation-response coupling sequence of human neutrophils
6. Crystal-induced neutrophil activation
7. Inhibition of tyrosme phosphorylation by U73122 in human neutrophils. Dissociation from its inhibitory effects on phospholipase D
8. Inflammatory microcrystals induce a distinct pattern of tyrosine phosphorylation in human neutrophils
9. 2+ concentration determinations in neutrophils stimulated by monosodium urate and calcium pyrophosphate crystals: Effect of protein adsorption
10. Enhancement of crystal induced neutrophil responses by opsonisation of calcium pyrophosphate dihydrate crystals
11. Crystal-induced protein tyrosine phosphorylation in neutrophils and the effect of a tyrosine kinase inhibitor on neutrophil responses
12. Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitor
13. The involvement of phosphatidylinositol 3-kinase in crystal induced human neutrophil activation
14. Pertussis toxin inhibits the FMLP-induced membrane association of protein kinase C in human neutrophils
15. Signal transduction in N-formyl-methionyl-leucyl-phenylalanine and concanavalin A stimulated neutrophils: Superoxide production without a rise in intracellular free calcium
16. Impairment of phosphatidylinositol signaling in acetylshikonin-treated neutrophils
17. 2+
18. Receptor-coupled signal transduction in human polymorphonuclear neutrophils: Effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness
19. Tyrosine phosphorylation of phospholipase C-γ2 is involved in the activation of phosphoinositide hydrolysis by Fc receptors in human neutrophils
20. In vitro tyrosine phosphorylation of PLC-γ1 and PLC-γ2 by SRC-family protein tyrosine kinases
21. Tyrosine phosphorylation and translocation of phospholipase C-γ2 in polymorphonuclear leukocytes treated with pervanadate
22. 3
23. Membranolytic effects of crystalline monosodium urate monohydrate
24. Characterization and membranolytic effects of calcium pyrophosphate dihydrate crystals
25. Effects of U73122 and U73343 on human platelet calcium signalling and protein tyrosine phosphorylation
26. Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils
27. The phospholipase C inhibitor U73122 inhibits phorbol ester-induced platelet activation
28. U73122: A potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces and adhesion related effector functions
29. Phospholipase C-γ1 and phospholipase C-γ2 are substrates of the B cell antigen receptor associated protein tyrosine kinase
30. Phospholipase C-γ1 is translocated to the membrane of rat basophilic leukemia cells in response to aggregation of IgE receptors
31. 1 couples the Fc, receptor mediated signal to mast cells secretion
32. The CD19 complex of B lymphocytes: Activation of phospholipase C by a protein tyrosine kinase dependent pathway that can be enhanced by membrane IgM complex
33. Intracellular signaling pathway of substance P-induced superoxide production in human neutrophils
34. Blockage of chemotactic peptide-induced stimulation of neutrophils by U73122 as a result of selective inhibition of phosphatidylinositol 3-kinase
35. U73122 is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-triphosphate in neutrophil responses
36. Activation of phospholipase Cγ by PI 3-kinase-induced PH domain-mediated membrane targeting
37. Fc-gamma and complement receptor mediated elevation in the cytosolic calcium level in human neutrophils
38. Protein tyrosine phosphorylation in leukocyte activation through receptors for IgG
39. Tyrosine phosphorylation and its possible role in superoxide production by human neutrophils stimulated with FMLP and IgG