Isolation of human adenovirus type 5 variants resistant to the antiviral cidofovir

Investigative Ophthalmology and Visual Science

Volumn 37, Issue 13, 1996, Pages 2774-2778

  Gordon, Y Jerold ^a   Araullo Cruz, T P ^a   Johnson, Y F ^a   Romanowski, E G ^a   Kinchington, P R ^a  

^a University of Pittsburgh School of Medicine   (United States)

Author keywords

(S) HPMPC; adenovirus; antiviral drugs; cidofovir; drug resistance

Indexed keywords

CIDOFOVIR;

ADENOVIRUS; ARTICLE; MINIMUM INHIBITORY CONCENTRATION; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS ISOLATION; VIRUS RESISTANCE; VIRUS TITRATION;

ADENOVIRUSES, HUMAN; ANTIVIRAL AGENTS; CYTOPATHOGENIC EFFECT, VIRAL; CYTOSINE; DRUG RESISTANCE, MICROBIAL; HUMANS; LUNG NEOPLASMS; MICROBIAL SENSITIVITY TESTS; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; TUMOR CELLS, CULTURED;

EID: 0030458329     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Gordon YJ. Adenoviruses and miscellaneous viral infections. In: Smolin G, Thoft R, eds. The Cornea. 3rd ed. Boston: Little, Brown; 1994:215-227.
2. Kimberlin DW, Coen DM, Biron KK, et al. Molecular mechanisms of antiviral resistance. Antiviral Res. 1995;26:369-401.
3. De Clercq E. Therapeutic potential of HPMPC as an antiviral drug. Rev Med Virol. 1993;85-96.
4. Gordon YJ, Romanowski EG, Araullo-Cruz T. Topical HPMPC inhibits adenovims type 5 in the New Zealand rabbit ocular replication model. Invest Ophthalmol Vis Sci. 1994;35:4135-4143.
5. Gordon YJ, Romanowski EG, Araullo-Cruz T. HPMPC, a broad-spectrum topical antiviral, inhibits HSV-1 replication and promotes healing of dendritic keratitis in the NZ rabbit ocular model. Cornea. 1994;13:516-520.
6. Andrei G, Snoeck R, DeClercq E. Antiviral drug susceptibility of HSV-1 strains emerging under the selective pressure of (S)-HPMPC in vitro. Antiviral Res. 1995;25:A312.
7. Mendel DB, Barkhimer DB, Kern ER, Chen MS. Isolation and initial characterization of a herpes simplex virus type 2 (HSV-2) with decreased sensitivity to cidofovir. Antiviral Res. 1995;25:A312.
8. Allen SJW, Mulato AS, Miner R, Drew WL, Chen MS. Sensitivities of human cytomegalovus (HCMV) clinical isolates to cidofovir. Antiviral Res. 1995;25:A319.
9. Smee DF, Barnett BB, Sidwell RW, Reist EJ, Holy A. Antiviral activities of nucleosides and nucleotides against wild-type and drug-resistant strains of murine cytomegaovirus. Antiviral Res. 1995;26:1-9.
10. Kimberlin DW, Crumpacker CS, Straus SE, et al. Antiviral resistance in clinical practice. Antiviral Res. 1995;26:423-438.