A novel imprinted gene, KCNQ1DN, within the WT2 critical region of human chromosome 11p15.5 and Its reduced expression in wilms' tumors

Journal of Biochemistry

Volumn 128, Issue 5, 2000, Pages 847-853

  Xin, Zhenghan ^a   Soejima, Hidenobu ^a   Higashimoto, Ken ^a   Yatsuki, Hitomi ^a   Zhu, Xike ^a   Satoh, Yuji ^a   Masaki, Zenjiro ^a   Kaneko, Yasuhiko ^b   Jinno, Yoshihiro ^c   Fukuzawa, Ryuji ^d   Hata, Jun Ichi ^d   Mukai, Tsunehiro ^a  

^a SAGA UNIVERSITY   (Japan)

^b SAITAMA CANCER CENTER   (Japan)

^c UNIVERSITY OF THE RYUKYUS   (Japan)

^d KEIO UNIVERSITY   (Japan)

Author keywords

CpG island; Genomic imprinting; Imprinted genes; KCNQ1DN; Wilms' tumors

Indexed keywords

ALLELE; ARTICLE; CARCINOGENESIS; CHROMOSOME 11P; CONTROLLED STUDY; CPG ISLAND; EXON; GENE EXPRESSION; GENE LOCATION; GENE MAPPING; GENE STRUCTURE; GENETIC POLYMORPHISM; GENOME IMPRINTING; GENOTYPE; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; NEPHROBLASTOMA; NUCLEOTIDE SEQUENCE; TISSUE SPECIFICITY;

EID: 0033672104     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022823     Document Type: Article

References (45)

1. Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis
2. Completion of mouse embryogenesis requires both the maternal and paternal genomes
3. Genetic linkage of Beckwith-Wiedemann Syndrome to 11p15
4. Multiple genetic loci within 11p15 defined by Beckwith-Wiedemann Syndrome rear rangement breakpoints and subchromosomal transferable fragments
5. Parental imprinting of human chromosome region 11p15.3-pter involved in the Beckwith-Wiedemann Syndrome and various human neoplasia
6. Human KvLQT1 gene shows tissue-specific imprinting and encompasses Beckwith-Wiedemann Syndrome chromosomal rearrangements
7. An imprinted gene p57(KIP2) is mutated in Beckwith-Wiedemann Syndrome
8. New p57(KIP2) mutations in Beckwith-Wiedemann Syndrome
9. Low frequency of p57(KIP2) mutation in Beckwith-wiedemann Syndrome
10. Coding mutations in p57(KIP2) are present in some cases of Beckwith-Wiedemann syndrome but are rare or absent in Wilms tumors
11. Loss of allelic heterozygosity at a second locus on chromosome 11 in sporadic Wilms' tumor cells
12. Less of heterozygosity in Wilms' tumor involves two distinct regions of chromosome 11
13. Loss of heterozygosity in Wilms' tumor, studied for six purgative tumor suppressor regions, is limited to chromosome 11
14. Loss of heterozygosity mapping in Wilms tumor indicates the involvement of three distinct regions and a limited role for nondisjunction or mitotic recombination
15. A common region of loss of heterozygosity in Wilms' tumor and embryonal rhabdomyosarcoma distal to the D11-S988 locus on chromosome 11P15.5
16. Wilms tumor genetics
17. A catalogue of imprinted genes and parent-of-origin effects in humans and animals
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19. A novel gene, ITM, located between p57(KIP2) and IPL, is imprinted in mice
20. LIT1, an imprinted antisenseRNA in the human KvLQT1 locus identified by screening for differentially expressedtranscripts using monochromosomal hybrids
21. Loss of imprinting of a paternally expressed transcript, with antisense orientation to KvLQT1, occurs frequently in Beckwith-Wiedemann syndrome and is independent of insulin-like growth factor II imprinting
22. Expression and imprinting status of human PEG8/IGF2AS, a paternally expressed antisense transcript from the IGF2 locus, in Wilms' tumors
23. Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression
24. Relaxation of imprinted genes in human cancer
25. Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour
26. Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome
27. Tumour-suppressor activity of H19 RNA
28. Role of the H19 gene in Syrian hamster embryo cell tumorigenicity
29. Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour
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31. p57(KIP2), a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene
32. Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57(KIP2), on chromosome 11p15
33. Reduced expression of the cyclin-dependent kinase inhibitor gene p57(KIP2) in Wilms' tumor
34. Genomic imprinting of human p57(KIP2) and its reduced expression in Wilms' tumors
35. Altered cell differentiation and proliferation in mice lacking p57(KIP2) indicates a role in Beckwith-Wiedemann syndrome
36. Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5
37. Tumor cell growth arrest caused by subchromosomal transferable DNA fragments from chromosome 11
38. Allele specific-PCR: A novel method for investigation of the imprinted IGF2 gene
39. Analysis of IGF2 gene imprinting in breast and colorectal cancer by allele specific-PCR
40. Polymerase chain reaction (PCR) for detection of ApaI polymorphism at the insulin like growth factor II gene (IGF2)
41. An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
42. Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: Long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human
43. Imprinting mechanisms in mammals
44. Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting
45. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2