Freeze-drying and lyopreservation of diblock and triblock poly(lactic acid)-poly(ethylene oxide) (PLA-PEO) copolymer nanoparticles

Pharmaceutical Development and Technology

Volumn 5, Issue 4, 2000, Pages 473-483

  De Jaeghere, Fanny ^a   Allémann, Eric ^a   Feijen, Jan ^b   Kissel, Thomas ^c   Doelker, Eric ^a   Gurny, Robert ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b UNIVERSITY OF TWENTE   (Netherlands)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Block copolymer; Freeze drying; Nanoparticles; Poly(ethylene oxide); Poly(lactic acid); Shelf stability

Indexed keywords

ETHYLENE OXIDE; MEDISORB 100 DL; NANOPARTICLE; POLYLACTIC ACID; RESOMER R 206; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATION; CRYOPRESERVATION; DRUG FORMULATION; DRUG STABILITY; FREEZE DRYING; MOLECULAR WEIGHT; PRIORITY JOURNAL; SURFACE PROPERTY;

DRUG DELIVERY SYSTEMS; DRUG STABILITY; FREEZE DRYING; LACTIC ACID; MOLECULAR CONFORMATION; POLYETHYLENE GLYCOLS; POLYMERS; TREHALOSE;

EID: 0033667280     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100102031     Document Type: Article

References (32)

1. Long circulating microparticulate drug carriers
2. Freeze-drying of bioproducts: Putting principles into practice
3. Poly-DL-lactic acid: Polyethylene glycol block copolymers. The influence of polyethylene glycol on the degradation of poly-DL-lactic acid
4. In-vitro degradation and bovine serum albumin release of the ABA triblock copolymers consisting of poly(L(+)lactic acid), or poly(L(+)lactic acid-co-glycolic acid) A-blocks attached to central polyoxyethylene B-blocks
5. Formulation and lyoprotection of poly(lactic acid-co-ethylene oxide) nanoparticles: Influence on physical stability and in vitro cell uptake
6. Stereocomplex formation in ABA triblock copolymers of poly(lactide) (A) and poly(ethylene glycol) (B)
7. Synthesis and properties of biodegradable ABA triblock copolymers consisting of poly(L-lactic acid) or poly(L-lactic-co-glycolic acid) A-blocks attached to central poly(oxyethylene) B-blocks
8. An investigation on the role of plasma and serum opsonins on the internalization of biodegradable poly(D,L-lactic acid) nanoparticles by human monocytes
9. Drug loaded poly(lactic acid) nanoparticles produced by a reversible salting-out process: Purification of an injectable dosage form
10. The effect of polyethylene oxide molecular weight on determination on its concentration in aqueous solutions
11. Synthesis and characterization of a short-haired poly(ethylene oxide)-grafted polystyrene latex
12. In vitro sustained release properties of drug loaded poly (D,L-lactic acid) nanoparticles produced by a salting-out procedure
13. MPEO-PLA nanoparticles: Effect of MPEO content on some of their surface properties
14. Surface modification of poly(lactide-co-glycolide) nanospheres by biodegradable poly(lactide)-poly(ethylene glycol) copolymers
15. Nonstealth (poly(lactic acid/albumin)) and stealth (poly(lactic acid-polyethylene glycol)) nanoparticles as injectable drug carriers
16. PEG-PLA nanoparticles avoid uptake by the mononuclear phagocytes system
17. Biodegradable long circulating polymeric nanospheres
18. Development of sterically stabilized poly(isobutyl 2-cyanoacrylate) nanoparticles by chemical coupling of poly(ethylene glycol)
19. PEG-coated nanospheres from amphiphilic diblock and multiblock copolymers: Investigation of their drug encapsulation and release characteristics
20. Thermophysical properties of trehalose and its concentrated aqueous solutions
21. Lyophilisation de vecteurs colloidaux submicroniques
22. Freeze-drying of itraconazole-loaded nanospheres suspensions: A feasibility study
23. Rational design of stable lyophilized protein formulations: Some practical advice
24. Effect of freezing rate on the stability of liposomes during freeze-drying and rehydration
25. Cryoprotective mechanism of saccharides on freeze-drying of liposome
26. Phase separation of excipients during lyophilization: Effects on protein stability
27. Effects of sugar and polymers on crystallization of poly(ethylene glycol) in frozen solutions: Phase separation between incompatible polymers
28. Freeze Drying: From empiricism to predictability
29. Effect of process conditions on recovery of protein activity after freezing and freeze-drying
30. Surface-induced denaturation of proteins during freezing and its inhibition by surfactants
31. Stability study of drug-loaded proteinoid microsphere formulations during freeze-drying
32. Surface denaturation at solid-void interface - A possible pathway by which opalescent particulates form during the storage of lyophilized tissue-type plasminogen activator at high temperatures