Physicochemical characterization of a new crystal form and improvements in the pharmaceutical properties of the poorly water-soluble antiosteoporosis drug 3,9-bis(N,N-dimethylcarbamoy-loxy)-5H-benzofuro[3,2-c]quinoline-6-one (KCA-098) by solid dispersion with hydroxypropylcellulose

Pharmaceutical Development and Technology

Volumn 5, Issue 4, 2000, Pages 443-454

  Yamada, Tatsuhiko ^a   Saito, Noriyasu ^a   Anraku, Makoto ^b   Imai, Teruko ^b   Otagiri, Masaki ^b  

^a KISSEI PHARMACEUTICAL CO LTD   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Absorption; Dissolution; Hydroxypropylcellulose; KCA 098; Solid dispersion

Indexed keywords

3,9 BIS(N,N DIMETHYLCARBAMOYLOXY) 5H BENZOFURO[3,2 C]QUINOLIN 6 ONE; HYDROXYPROPYLCELLULOSE; POVIDONE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; CRYSTAL; DIFFERENTIAL SCANNING CALORIMETRY; DOG; DRUG ABSORPTION; DRUG CAPSULE; DRUG SOLUBILITY; INFRARED SPECTROSCOPY; MALE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; X RAY POWDER DIFFRACTION;

EID: 0033667237     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100102028     Document Type: Article

References (31)

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5. Synthesis of novel 2-benzothiopyran and 3-benzothiepin derivatives and their stimulatory effect on bone formation
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