On the pathogenesis of perforin defects and related immunodeficiencies [2]

Immunology Today

Volumn 21, Issue 11, 2000, Pages 593-

  Moretta, Lorenzo ^a   Moretta, Alessandro ^a   Hengartner, Hans ^b   Zinkernagel, Rolf M ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PERFORIN;

EFFECTOR CELL; FAMILIAL DISEASE; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOSTIMULATION; LETTER; OSMOSIS; PRIORITY JOURNAL; PROTEIN DEFECT; REGULATORY MECHANISM; T LYMPHOCYTE ACTIVATION;

EID: 0033666758     PISSN: 01675699     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5699(00)01731-X     Document Type: Letter

References (7)

1. S.E. Stepp Perforin gene defects in familial hemophagocytic lymphohistiocytosis Science 286 1999 1957 1959
2. S.E. Stepp Perforin: more than just an effector molecule Immunol. Today 21 2000 254 256
3. D. Kagi Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo Annu. Rev. Immunol. 14 1996 207 232
4. C. Klein Partial albinism with immunodeficiency (Griscelli syndrome) J. Pediatr. 125 1994 886 895
5. E. Pastural Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene Nat. Genet. 16 1997 289 292
6. J. Sayos The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM Nature 395 1998 462 469
7. S. Parolini X-linked lymphoproliferative disease: 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein–Barr virus-infected cells J. Exp. Med. 192 2000 337 346