Expression and in vitro properties of guinea pig IL-5: Comparison to human and murine orthologs

Mediators of Inflammation

Volumn 9, Issue 3-4, 2000, Pages 181-187

  Scott, C W ^a   Budzilowicz, C ^a   Hubbs, S J ^a   Stein, M ^a   Sobotka Briner, C ^a   Wilkins, D E ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Airway inflammation; Asthma; Eosinophil; Interleukin 5

Indexed keywords

ANIMAL CELL; ARTICLE; ASTHMA; BINDING AFFINITY; CELL PROLIFERATION; GUINEA PIG; IMMUNE RESPONSE; IN VITRO STUDY; LIGAND BINDING; LUNG LAVAGE; MEDIATOR RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY;

ANIMALIA; CAVIA; CAVIA PORCELLUS; INSECTA; MURINAE; SUS SCROFA;

EID: 0033663437     PISSN: 09629351     EISSN: None     Source Type: Journal    
DOI: 10.1080/09629350020008709     Document Type: Article

References (35)

1. Eosinophil function in health and disease
2. Eosinophils
3. Eosinophilic inflammation in asthma
4. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity
5. Eosinophilic inflammation is associated with elevation of interleukin-5 in the airways of patients with spontaneous symptomatic asthma
6. Role of IL-5 in the development of allergen-induced airway hyperresponsiveness
7. Cytokines as targets for the inhibition of eosinophilic inflammation
8. Interleukin-5 and its receptor: A drug target for eosinophilia associated with chronic allergic disease
9. Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma
10. Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: The role of specific adhesion molecules and phosphatidylinositol 3-kinase
11. Production and characterization of guinea pig IL-5 in baculovirus-infected insect cells
12. Reconstitution of the functional receptors for murine and human interleukin 5
13. Detailed analysis of the IL-5-IL-5R alpha interaction: Characterization of crucial residues on the ligand and the receptor
14. Identification of key charged residues of human interleukin-5 in receptor binding and cellular activation
15. Delineation of IL-5 domains predicted to engage the IL-5 receptor complex
16. Mutants of single chain interleukin 5 show asymmetric recruitment of receptor alpha and betac subunits
17. Effects of interleukin 5-induced pulmonary eosinophilia on airway reactivity in the guinea pig
18. Molecular cloning of the guinea pig IL-5 receptor alpha and beta subunits and reconstitution of a high affinity receptor
19. A single-step purification of biologically active recombinant human interleukin-5 from a baculovirus expression system
20. Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins
21. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
22. Interleukin 5 synthesis by eosinophils: Association with granules and immunoglobulin-dependent secretion
23. Eosinophils and eosinophil-associated cytokines in allergic inflammation
24. Production and purification of recombinant human interleukin-5 from yeast and baculovirus expression systems
25. Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils
26. Characterization of a receptor for interleukin 5 on human eosinophils: Variable expression and induction by granulocyte/macrophage colony-stimulating factor
27. Characterization of the human IL-5 receptors on eosinophils
28. Monoclonal antibodies reactive with the mouse interleukin 5 receptor
29. Analysis of interleukin 5 receptors on murine eosinophils: A comparison with receptors on B13 cells
30. Interaction of interleukin-5 with its receptors on murine leukemic BCL1 cells and its implication in biological activity
31. Structure-function analysis of interleukin-5 utilizing mouse/human chimeric molecules
32. Restoring the apoptosis suppression response to IL-5 confers on erythroleukemic cells a phenotype of IL-5-dependent growth
33. Characterization of a receptor for interleukin-5 on human eosinophils and the myeloid leukemia line HL-60
34. Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist
35. Mutagenesis in the C-terminal region of human interleukin 5 reveals a central patch for receptor alpha chain recognition