Modulation by soluble factors of gelatinase activities released by osteoblastic cells

Cytokine

Volumn 12, Issue 11, 2000, Pages 1727-1731

  Damiens, Christelle ^a   Fortun, Yannick ^a   Charrier, Céline ^a   Heymann, Dominique ^a   Padrines, Marc ^a  

^a Universite de Nantes   (France)

Author keywords

Gelatinases; Human osteoblasts; Osteosarcoma; Soluble factors

Indexed keywords

GELATINASE A; GROWTH HORMONE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; ONCOSTATIN M; PROTEIN; SOMATOMEDIN;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REGULATION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; OSTEOBLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; SARCOMA CELL; ZYMOGRAPHY;

EID: 0033662271     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.2000.0765     Document Type: Article

References (16)

1. Matrix metalloproteinases
2. Inhibition of bone resorption in vitro by selective inhibitors of gelatinases and collagenases
3. Matrix metalloproteinase-2 is an interstital collagenase. Inhibitor-free enzymes catalyses the cleavage of collagen fibrils and soluble native type 1 collagen generating the specific 3/4- and 1/4-length fragments
4. Human osteoblasts in culture synthesis collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines
5. Regulation of matrix metalloproteinases (MMP-2,-3, -9 and -13) by interleukin-1 and interleukin-6 in mouse calvaria: Association of MMP induction with bone resportion
6. The synthesis of collagenase, gelatinase-A (72 kDA) and -B (92 kDA), and TIMP-1 and -2 by human osteoblasts from normal and arthritic bone
7. Stimulation by human interleukin 1 of cartilage breakdown and production of collagenase and proteoglycanase by human chondrocytes but not by human osteoblasts in vitro
8. 2d-Page reveals the absence of collagenase production in normal human osteoblasts in culture
9. Expression of metalloproteinases and tissue inhibitors of metalloproteinases in human osteoblast-like cells: Differentiation is associated with repression of metalloproteinase biosynthesis
10. Cysteine protease production by human osteosarcoma cells (MG63, SaOS2) and its modulation by soluble factors
11. Insulin-like growth factor I has independent effects on bone matrix formation and cell replication
12. Osteoblasts mediate insulin-like growth factor I and -II stimulation of osteoclast formation and function
13. Normal human osteoblast-like cells consistently express genes for insulin-like growth factors I and II but tranformed human osteoblast cell lines do not
14. Role of tissue inhibitor of metalloproteinases-2 (TIMP-2) in regulation of pro-gelatinase A activation catalyzed by membrane-type matrix metalloproteinase-1 (MT1-MMP) in human cancer cells
15. Initiation of osteoclast bone resorption by interstitial collagenase
16. Are MG-63 and HOS TE85 human osteosarcoma cell lines representative models of the osteoblastic phenotype?