Aging, immunity, and cancer

Cancer Control

Volumn 7, Issue 6, 2000, Pages 513-521

  Burns, Edith A ^a   Leventhal, Elaine A ^b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; APOPTOSIS; ARTICLE; CANCER; CANCER RISK; DISEASE PREDISPOSITION; GENE MUTATION; HUMAN; IMMUNITY;

EID: 0033660417     PISSN: 10732748     EISSN: None     Source Type: Journal    
DOI: 10.1177/107327480000700603     Document Type: Article

References (168)

1. Age-related effects in T cell activation and proliferation
2. Age, thymic involution and circulating thymic hormone activity
3. Aging and immune function
4. Diminished calcium signal generation in subsets of T lymphocytes that predominate in old mice
5. Age-related increase in the fraction of CD27-CD4+ T cells and IL-4 production as a feature of CD4+ T cell differentiation in vivo
6. Age-associated changes in human T cell phenotype and function
7. A comprehensive analysis of peripheral blood lymphocytes in healthy aged humans by flow cytometry
8. Differential expression of various T cell surface markers in young and elderly subjects
9. Age-associated changes in human T cell phenotype and function
10. Enrichment for Th1 cells in the Mel-14+ CD4+ T cell fraction in aged mice
11. Mel14+CD4+ T cells from aged mice display functional and phenotypic characteristics of memory cells
12. Intrathymic differentiation of V gamma 3T cells
13. Bone marrow CD34 cells generate fewer T cells in vitro with increasing age and following chemotherapy
14. Aging, immune response and mortality
15. Association of lack of mitogen-induced lymphocyte proliferation with increased mortality in the elderly
16. Immunological studies of aging. III. Cytokinetic basis for the impaired response of lymphocytes from aged humans to plant lectins
17. Sensitivity of lymphocytes to prostaglandin E2 increases in subjects over age 70
18. Splenic and inguinal lymph node T cells of aged mice respond differently to polyclonal and antigen-specific stimuli
19. Stimulation of murine T cell subsets with anti-CD3 antibody: Age-related defects in the expression of early activation molecules
20. Molecular aspects of the relationship between cancer and aging: Tumor suppressor activity during cellular senescence
21. p53, the cellular gatekeeper for growth and division
22. Differential expression of p53 tumor suppressor protein and IL-2 in activated T cells from elderly humans
23. Accelerated development and aging of the immune system in p53-deficient mice
24. A decreased functional capacity of CD4+T cells underlies the impaired DTH reactivity in old mice
25. Proliferative and cytotoxic immune functions in aging mice. V. Deficiency in generation of cytotoxic cells with normal lytic function per cell as demonstrated by the single cell conjugation assay
26. Humoral and cellular immune response to influenza virus vaccination in aged humans
27. IgD-receptor upregulation on human peripheral blood T cells in response to IgD in vitro or antigen in vivo correlates with the antibody response to influenza vaccination
28. Age-related decline in interleukin 2 production in response to influenza vaccine
29. Recombinant vaccinia virus expressing the PR/8 influenza hemagglutinin gene overcomes the impaired immune response and increased susceptibility of old mice to influenza infection
30. Population-based study of herpes zoster and its sequelae
31. Immune responses to varicella-zoster in the aged
32. The incidence of herpes zoster
33. Risk of cancer after herpes zoster: A population-based study
34. Age-related changes in suppressor functions of human T cells
35. Reduced proliferation in T lymphocytes in aged humans is predominantly in the CD8+ subset and is unrelated to defects in transmembrane signaling which are predominantly in the CD4+ subsets
36. Age restriction in antigen-specific immunosuppression
37. Age-dependent appearance of non-major histocompatibility complex-restricted helper T cells
38. Age-associated changes in proliferative and differentiative response of human B cells and production of T cell-derived factors regulating B cell functions
39. Lymphocyte phytohemagglutinin responsiveness, immunoglobulins, and autoantibodies in aging humans
40. Biology of aging: Retrospect and prospect
41. Loss of immune competence with age may be due to a qualitative abnormality in lymphocyte membranes
42. Age-related changes in the capability, of the bone marrow to generate B cells
43. Bone marrow declines as a site of B-cell precursor differentiation with age: Relationship to thymus involution
44. VH-gene family dominance in ageing mice
45. Immunosenescence: Clinical and pharmacologic considerations
46. Altered major histocompatibility complex-restricted antigen recognition by T cells from elderly humans
47. Dysregulation of the humoral immune response in old mice
48. Lower antibody response to tetanus toxoid associated with higher auto-anti-idiotypic antibody in old compared with young humans
49. Aging and the immune system: Report on Workshop 94 held during the 7th International Congress of Immunology; August 3, 1989: Berlin
50. Factors influencing the secondary antibody response to flagellin in man
51. Effect of age, sex and depression on response to primary and secondary immunization
52. Admission criteria for immunogerontological studies in man: The SENIEUR protocol
53. Age-related changes of the antigen-specific antibody formation in vitro and PHA-induced T-cell proliferation in individuals who met the health criteria of the SENIEUR protocol
54. Age-related decrease in frequencies of B-cell precursors and specific helper T cells involved in the IgG anti-tetanus toxoid antibody production in humans
55. Decreased specific antibody synthesis in old adults: Decreased potency of antigen-B cells with aging
56. Specific humoral immunity in the elderly: In vivo and in vitro response to vaccination
57. Improvement of the immunoglobulin subclass response to influenza vaccine in elderly nursing-home residents by the use of high-dose vaccines
58. Functional analysis of the immunosenescence of the human B cell system: Dissociation of normal activation and proliferation from impaired terminal differentiation into IgM immunoglobulin-secreting cells
59. Human B cell proliferative responses during aging: Reduced RNA synthesis and DNA replication after signal transduction by surface immunoglobulins compared to B cell antigenic determinants CD20 and CD40
60. Effect of age on the expressed B cell repertoire: Role of B cell subsets
61. Repertoire diversity of antibody response to bacterial antigens in aged mice. III. Phosphorylcholine antibody from young and aged mice differ in structure and protective activity against infection with Streptococcus pneumoniae
62. Antibody protection in aging: Influence of idiotypic repertoire and antibody binding activity to a bacterial antigen
63. Ig VH hypermutation is absent in the germinal centers of aged mice
64. Increase of cross(auto)-reactive antibodies after immunization in aged mice: A cellular and molecular study
65. Abolished in vitro antibody response in elderly: Exclusive involvement of prostaglandin-induced T suppressor cells
66. Age-related impairment of the in vitro antibody response in the human
67. Immunological functions of aged human monocytes
68. Promotion of wound repair in old mice by local injection of macrophages
69. Age-related decrease in the number of hemopoietic stem cells and progenitors in senescence accelerated mice
70. Follicular dendritic cells in the alternative antigen transport pathway: Microenvironment, cellular events, age and retrovirus related alterations
71. T cell activation in the elderly: Evidence for specific deficiencies in T cell/accessory cell interactions
72. Antitumoral properties of aged human monocytes
73. Age-related variation in the proportion and activity of murine liver natural killer cells and their cytotoxicity against regenerating hepatocytes
74. Effect of host age upon interleukin-2-mediated anti-tumor responses in a murine fibrosarcoma model
75. Basal natural killer cell activity of young versus elderly humans
76. Increased number of circulating Leu11+ (CD16) large granular lymphocytes and decreased NK activity during human ageing
77. Natural killer cell cytotoxicity in elderly humans after influenza immunization
78. Acquisition of Ly 49 receptor expression by developing natural killer cells
79. Effects of aging on natural killer cell activity and activation by interleukin-2 and IFN-alpha
80. Insulin-like growth factor I is an independent coregulatory modulator of natural killer (NK) cell activity
81. The aging/cancer connection
82. Alterations in DNA methylation: A fundamental aspect of neoplasia
83. Genes, immunity, and senescence: Looking for a link
84. Apoptosis: A two-edged sword in aging
85. Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases
86. Chromosomes of older humans are more prone to aminopterin-induced breakage
87. Age and dose related alteration of in vitro mixed lymphocyte culture response of blood lymphocytes from A-bomb survivors
88. Age-dependent decline in rejoining of X-ray-induced DNA double-strand breaks in normal human lymphocytes
89. Sister chromatid exchange and proliferation pattern in lymphocytes from newborns, elderly subjects and in premature aging syndromes
90. Molecular interactions of cancer and age
91. Micronutrients prevent cancer and delay aging
92. Vitamin E
93. Vitamin E and immune response
94. In vitro glutathione supplementation enhances interleukin-2 production and mitogenic response of peripheral blood mononuclear cells from young and old subjects
95. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects: A randomized controlled trial
96. Long-term vitamin E supplementation enhances immune response in healthy elderly
97. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects
98. Mechanisms of age-related decline in antigen-specific T cell proliferative response: IL-2 receptor expression and recombinant IL-2 induced proliferative response of purified Tac-positive T cells
99. Analysis of the age-related decline in alloreactivity of CD4+ and CD8+ T cells in CBA/RIJ mice
100. Age-related changes of expression of IL-2 receptor subunits and kinetics of IL-2 internalization in T cells after mitogenic stimulation
101. Effect of age on the human high affinity interleukin 2 receptor of phytohaemagglutinin stimulated peripheral blood lymphocytes
102. Age associated changes in mitogen induced proliferation and cytokine production by lymphocytes of the long-lived brown Norway rat
103. In vivo immunologic intervention in age-related T cell defects in murine gut- associated lymphoid tissues by IL-2
104. Cell proliferation and cytokine production by CD4+ cells from old mice
105. The effect of aging on the expression of interleukin 2 messenger ribonucleic acid
106. Secretion of cytokines upon allogeneic stimulation: Effect of aging
107. Impaired autoreactive T cell-induced T cell-T cell interaction in aged mice
108. Response of aged T and B cells to IL-4
109. Age-associated decline in II-4 production by murine T lymphocytes in extended culture
110. The in vivo effects of neutralizing antibodies against IFN-gamma, IL-4, or IL-10 on the humoral immune response in young and aged mice
111. Effects of Interleukin-4 on antigen-specific antibody synthesis by lymphocytes from old and young adults
112. gamma-Interferon, interleukin-4 and interleukin-6 in vitro production in old subjects
113. Age-related changes in lymphokine production related to a decreased number of CD45RBhi CD4+ T cells
114. Effects of aging on natural killer cell activity and activation by interleukin-2 and IFN-alpha
115. Cytokine sensitivity of human NK cells during immunosenescence. 2. IL-2-induced interferon gamma secretion
116. Cytokine production pathway in the elderly
117. Immunomodulatory therapy with thymopentin and indomethacin: Successful restoration of interleukin-2 synthesis in patients undergoing major surgery
118. Interleukin 2, interleukin 2 receptor, and interferon-gamma synthesis and mRNA expression in phorbol myristate acetate and calcium ionophore A23187-stimulated T cells from elderly humans
119. Altered regulation of IL-6 production with normal aging: Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative
120. Interleukin-6: A cytokine for gerontologists
121. Circadian characteristics of circulating interleukin-6 in men
122. Increased urinary cytokine levels in the elderly
123. Fever, tumor necrosis factor and interleukin-6 in young, mature and aged Fischer 344 rats
124. Cytokine production and aging: Over-production of IL-8 in elderly males in response to lipopolysaccharide
125. Old mice are able to control low-dose aerogenic infections with Mycobacterium tuberculosis
126. Evidence for a defective accumulation of protective T cells in old mice infected with Mycobacterium tuberculosis
127. Mechanisms underlying the increased susceptibility of aged mice to tuberculosis
128. Characteristics and specificity of acquired immunologic memory to Mycobacterium tuberculosis infection
129. The response of macrophages from old mice to Mycobacterium tuberculosis and its products
130. Altered Th1/Th2 commitment in human CD4+ T cells with ageing
131. Corrective effects of interleukin-12 on age-related deficiencies in IFN-gamma production and IL-12Rbeta2 expression in virus-specific CD8+ T cells
132. Potassium and calcium channels in lymphocytes
133. The inositol 1,4,5-trisphosphate receptor is essential for T-cell receptor signaling
134. Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores
135. Defective control of cytoplasmic calcium concentration in T lymphocytes from old mice
136. Calcium signals in T lymphocytes from old mice
137. Transmembrane signaling changes with aging
138. Calcium signals in murine T lymphocytes: Preservation of response to PHA and to an anti-Ly-6 antibody
139. Impaired humoral immune responses to mycobacterial antigen in aged murine gut-associated lymphoid tissues
140. Aging and the mobilization of intracellular calcium by phytohemagglutinin in human T cells
141. Diminished cell-cell binding by lymphocytes from healthy elderly humans: Evidence for altered activation of LFA-1 function with age
142. Age-related reductions in the activation of mitogen-activated protein kinases p44mapk/ERK1 and p42mapk/ERK2 in human T cells stimulated via ligation of the T cell receptor complex
143. Differential expression of the alpha- and beta-isoforms of protein kinase C in peripheral blood T and B cells from young and elderly adults
144. Age-associated changes in mitogen-induced protein phosphorylation in murine T lymphocytes
145. Differential tyrosine-specific protein phosphorylation in mouse T lymphocyte subsets: Effect of age
146. Age-related decreases in IL-2 production by human T cells are associated with impaired activation of nuclear transcriptional factors AP-1 and NF-AT
147. Reduced activation of transcriptional factor AP-1 among peripheral blood T cells from elderly humans after PHA stimulation: Restorative effect of phorbol diesters
148. Age-related alterations in the activation and expression of phosphotyrosine kinases and protein kinase C (PKC) among human B cells
149. Decreased immunity and increased morbidity in the elderly
150. Absolute peripheral blood lymphocyte counts and subsequent mortality of elderly men. The Baltimore Longitudinal Study of Aging
151. Immune parameters in a longitudinal study of a very old population of Swedish people: A comparison between survivors and nonsurvivors
152. Immunological responses of healthy elderly population
153. Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60
154. The concept of immunological surveillance
155. Reactions to homologous tissue antigens in relation to hypersensitivity
156. Aging, immunity and malignancy
157. Epidemiology of cancer
158. Cancer and age
159. The NZB mouse as a model for chronic lymphocytic leukemia
160. Genetic regulation of CD5+ B cells in autoimmune disease and in chronic lymphocytic leukemia
161. Regulatory role of T cells in a murine model of lymphoproliferative disease
162. Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions
163. Accelerated development and aging of the immune system in p53-deficient mice
164. Genetic alterations during colorectal-tumor development
165. Age-related factors in cancers of the breast, ovary and endometrium
166. Distribution of non-Hodgkin's lymphoma in the United States between 1950 and 1975
167. The biology of aging: The current research agenda
168. Cancer and aging