Specificity and binding kinetics of murine lupus anti-DNA monoclonal antibodies implicate different stimuli for their production

Immunology

Volumn 101, Issue 3, 2000, Pages 371-377

  Eivazova, E R ^a   McDonnell, J M ^a   Sutton, B J ^a   Staines, N A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; MONOCLONAL ANTIBODY; OLIGONUCLEOTIDE;

ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CELL DEATH; DNA STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURFACE PLASMON RESONANCE; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; AUTOIMMUNE DISEASES; DNA; DNA, SINGLE-STRANDED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED MRL LPR; OLIGONUCLEOTIDES; SURFACE PLASMON RESONANCE;

EID: 0033653484     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2000.00119.x     Document Type: Article

References (32)

1. Antibodies to polynucleotides in human sera: Antigenic specificity and relation to disease
2. Genesis and pathogenicity of anti-DNA antibodies
3. Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits
4. Expression and relationships of seven public idiotypes of DNA-binding autoantibodies on monoclonal antibodies and serum immunoglobulins
5. Susceptibility loci for lupus: A guiding light from murine models?
6. The genetics of lupus
7. Pathogenic idiotypes of autoantibodies in autoimmunity: Lessons from new experimental models of SLE
8. T and B cell recognition of idiotypes of anti-DNA autoantibodies
9. Induction of cross-reactive anti-dsDNA antibodies in pre-autoimmune NZB/NZW mice by immunization with bacterial DNA
10. Specificity and immunochemical properties of antibodies to bacterial DNA in sera of normal human subjects and patients with systemic lupus erythematosus (SLE)
11. Antibodies against DNA autoantibody idiotopes defined by idiopeptides appear in parallel with anti-double stranded DNA autoantibodies in systemic lupus erythematosus
12. Crossreactivity of anti-idiotypic antibodies with DNA in systemic lupus erythematosus
13. Molecular modelling of an anti-DNA autoantibody (V-88) and mapping of its V region epitopes recognized by heterologous and autoimmune antibodies
14. Five groups of antigenic determinants on DNA identified by monoclonal antibodies from (NZB x NZW) F1 and MRL/lpr/lpr mice, Immunology
15. A monoclonal DNA-binding autoantibody causes a deterioration in renal function in MRL mice with lupus disease
16. Surface plasmon resonance for detection and measurement of antibody-antigen affinity and kinetics
17. Determination of anti-idiotype antibodies by surface plasmon resonance
18. Structural and affinity studies of IgM polyreactive natural autoantibodies
19. Difference in affinity between HMG proteins 1 and 2 determined by surface plasmon resonance measurements
20. Interpretation of deviations from pseudo-first-order kinetic behaviour in the characterization of ligand binding by biosensor technology
21. Divesity and multispecificity of autoantibodies reactive with DNA; some evolutionary implications
22. Structure-function correlates of autoantibodies to nucleic acids. Lessons from immunochemical, genetic and structural studies
23. Cell death: The significance of apoptosis
24. Apoptotic death in epithelial cells: Cleavage of DNA to 300 and/or 50 kb fragments prior to or in the presence of internucleosomal fragmentation
25. A caspase activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
26. Formation of large scale molecular weight fragments of DNA is a key committed step of apoptosis m thymocytes
27. Large scale fragmentation of mammalian DNA in the course of apoptosis proceeds via excision of chromosomal DNA loops and their oligomers
28. The structure of an oligo (dA)-(dT) tract and its biological implications
29. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
30. Autoantigens as substrates for apoptotic proteases: Implications for the pathogenesis of systemic autoimmune disease
31. 1 mice