Different subcellular localizations for the related interferon-induced GTPases, MuGBP-1 and MuGBP-2: Implications for different functions?

Journal of Interferon and Cytokine Research

Volumn 20, Issue 11, 2000, Pages 991-1000

  Vestal, D J ^a   Gorbacheva, V Y ^a   Sen, G C ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN 1; GUANINE NUCLEOTIDE BINDING PROTEIN 2; GUANOSINE DIPHOSPHATE; GUANOSINE PHOSPHATE; GUANOSINE TRIPHOSPHATASE; INTERFERON; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; EMBRYO; FIBROBLAST; ISOPRENYLATION; MACROPHAGE; MEMBRANE VESICLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

3T3 CELLS; ANIMALS; CELLS, CULTURED; CYTOPLASMIC VESICLES; DNA-BINDING PROTEINS; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; INTERFERON TYPE II; INTRACELLULAR MEMBRANES; MACROPHAGES; MICE; MUTATION; PROTEIN ISOPRENYLATION; TRANSFECTION;

EID: 0033652395     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/10799900050198435     Document Type: Article

References (89)

1. The human interferon-γ receptor system
2. Jak-Stat pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
3. The molecular cell biology of interferon-gamma and its receptor
4. Recent progress in the elucidation of interferon-gamma actions: Molecular biology and biological functions
5. Interferon-gamma: A key immunoregulatory lymphokine
6. Interferon regulatory factor 1 is required for mouse Gbp gene activation by gamma interferon
7. Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein
8. Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene
9. Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons
10. Interferon induction of gene transcription analyzed by in vivo footprinting
11. Promoter analysis of an interferon-inducible gene associated with macrophage activation
12. Interferon induction of fibroblast proteins with guanylate binding activity
13. Two families of GTPases dominate the complex cellular response to IFN-γ
14. Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP
15. Identification and characterization of a new gene family induced during macrophage activation
16. Murine GBP-2: A new IFN-γ-induced member of the GBP family of GTPases isolated from macrophages
17. Genomic organization and chromosomal localization of a new member of the murine interferon-induced guanylate-binding protein family
18. Molecular cloning and characterization of an isoprenylated 67 kDa protein
19. Chicken guanylate-binding protein. Conservation of GTPase activity and induction by cytokines
20. Cloning, expression, and characterization of a novel guanylate-binding protein, GBP3, in murine erythroid progenitor cells
21. Alpha interferon and gamma interferon stimulate transcription of a single gene through different signal transduction pathways
22. Interferon-induced guanylate binding protein-1 (GBP-1) mediates an antiviral effect against vesicular stomatitis virus and encephalomyocarditis virus
23. GTP-binding domain: Three consensus sequence elements with distinct spacing
24. The GTP-binding domain revisited
25. A model for the tertiary structure of p21, the product of the ras oncogene
26. Affinity purification of an interferon-induced human guanylate-binding protein and its characterization
27. Genetic control of interferon action: Mouse strain distribution and inheritance of an induced protein with guanylate-binding property
28. The interferon-induced 67-kDa guanylate-binding protein (hGBP1) is a GTPase that converts GTP to GMP
29. GTPase properties of the interferon-induced human guanylate-binding protein 2
30. Nucleotide-binding characteristics of human guanylate-binding protein 1 (hGBP-1) and identification of the third GTP-binding motif
31. Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins
32. GTPases: Multifunctional molecular switches regulating vesicular traffic
33. Dynamin GTPase, a force-generating molecular switch
34. Activation of dynamin GTPases is a result of positive cooperativity
35. Dynamin self-assembly stimulates its GTPase activity
36. Participation of dynamin in the biogenesis of cytoplasmic vesicles
37. Endocytosis: Is dynamin a 'blue collar' or 'white collar' worker?
38. Functional diversity in the dynamin family
39. Posttranslational modification of proteins by isoprenoids in mammalian cells
40. The prenylation of proteins
41. Biochemistry of protein prenylation
42. Prenylation of an interferon-γ-induced GTP-binding protein: The human guanylate binding protein, HuGBP-1
43. Rat p67 GBP is induced by interferon-gamma and isoprenoid-modified in macrophages
44. Murine GBP1: Incomplete C20 isoprenoid modification of an IFNγ-inducible GTP-binding protein
45. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity
46. Isoprenoid modification and plasma membrane association: Critical factors for ras oncogenicity
47. Polylysine domain of K-ras 4B protein is crucial for malignant transformation
48. Regulators of small GTPases
49. Rab GDP dissociation inhibitor as a general regulator for the membrane association of Rab proteins
50. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses
51. M-Ras/R-Ras3, a transforming Ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6
52. Induction of interferon synthesis and activation of interferon-stimulated genes by liposomal transfection reagents
53. Liposomal induction of NO synthase expression in cultured vascular smooth muscle cells
54. A protein tyrosine kinase in the interferon alpha/beta signaling pathway
55. The protein tyrosine kinase Jak1 complements defects in interferon-alpha/beta and -gamma signal transduction
56. Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Major sialoglycoproteins carrying polylactosaminoglycan
57. The small GTP-binding protein Rab4 controls an early sorting event on the endocytic pathway
58. Rab4 and Rab7 define distinct nonoverlapping endosomal compartments
59. Regulation of membrane transport through the endocytic pathway by rabGTPases
60. Receptor-mediated endocytosis: The intracellular journey of transferrin and its receptor
61. Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
62. Sorting of lysosomal membrane glycoproteins lamp-1 and lamp-2 into vesicles distinct from mannose 6-phosphate receptor/γ-adaptin vesicles at the trans-Golgi network
63. The 70 kDa peroxisomal membrane protein: An ATP-binding cassette transporter protein involved in peroxisome biogenesis
64. The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glycoprotein)-related ATP-binding protein superfamily
65. Nucleotide sequence of the human 70 kDa peroxisomal membrane protein: A member of ATP-binding cassette transporters
66. Kinetically coordinated induction of TAP1 and HLA class I by IFN-gamma: The rapid induction of TAP1 by IFN-gamma is mediated by Stat1 alpha
67. Clathrin and adaptors
68. Linking cargo to vesicle formation: Receptor tail interactions with coat proteins
69. Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network
70. Different domains of the AP-1 adaptor complex are required for Golgi membrane binding and clathrin recruitment
71. Biochemical dissection of AP-1 recruitment onto Golgi membranes
72. Interaction of phosphoinositide cycle intermediates with the plasma membrane-associated clathrin assembly protein AP-2
73. Redistribution of clathrin-coated vesicle adaptor complexes during adipocytic differentiation of 3T3-L1 cells
74. Rab GTPases, directors of vesicle docking
75. The diversity of Rab proteins in vesicle transport
76. Rab proteins
77. Prenylation-dependent interaction of Rab proteins with GDP dissociation inhibitors
78. Identification of a GDI displacement factor that releases endosomal Rab GTPases from Rab-GDI
79. Isoprenylation of Rab1B is impaired by mutations in its effector domain
80. Properties of Rab5 N-terminal domain dictate prenylation of C-terminal cysteines
81. Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro
82. Regions outside of the CAAX motif influence the specificity of prenylation of G protein gamma subunits
83. The function of dynamin in endocytosis
84. Dynamin, endocytosis and intracellular signalling
85. The dynamins: Redundant or distinct functions for an expanding family of related GTPases?
86. Importance of the pleckstrin homology domain of dynamin in clathrin-mediated endocytosis
87. Essential role of the dynamin pleckstrin homology domain in receptor-mediated endocytosis
88. Synergistic activation of dynamin GTPase by Grb2 and phosphoinositides
89. Impairment of dynamin's intramolecular GAP stimulates receptor-mediated endocytosis