The effect of 17β-estradiol, and the phytoestrogens Genistein and Daidzein on neointima development in endothelium-denuded female rabbit aortae - An in vitro study

Endothelium: Journal of Endothelial Cell Research

Volumn 7, Issue 2, 2000, Pages 99-107

  Finking, G ^a   Wohlfrom, M ^a   Lenz, C ^a   Wolkenhauer, M ^a   Eberle, C ^a   Brehme, U ^a   Bruck, B ^a   Hanke, H ^a  

^a Dept of Int Medicine II/Cardiology ^*

Author keywords

[No Author keywords available]

Indexed keywords

DAIDZEIN; ESTRADIOL; GENISTEIN; PHYTOESTROGEN; ACTIN; ENZYME INHIBITOR; ESTROGEN; ESTROGEN RECEPTOR; ISOFLAVONE DERIVATIVE; PLANT MEDICINAL PRODUCT;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA INTIMA; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM; FEMALE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RABBIT; ABDOMINAL AORTA; ANIMAL; DRUG EFFECT; INJURY; VASCULAR ENDOTHELIUM;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

ACTINS; ANIMALS; AORTA, ABDOMINAL; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; ESTRADIOL; ESTROGENS, NON-STEROIDAL; FEMALE; GENISTEIN; ISOFLAVONES; PHYTOESTROGENS; PLANT PREPARATIONS; RABBITS; RECEPTORS, ESTROGEN;

EID: 0033643999     PISSN: 10623329     EISSN: None     Source Type: Journal    
DOI: 10.3109/10623320009072205     Document Type: Article

References (52)

1. Adlercreutz, H., Markkanen, H., and Watanabe, S. (1993) Plasma concentrations of phyto-oestrogens in Japanese men. Lancet 342, 1209-1210.
2. Akiyama, T., Ishida, J., Nakagawa, S., Ogawara, H., Watanabe, S., Itoh, N., Shibuya, M., and Fukami, Y. (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262, 5592-5595.
3. Anthony, M.S., Clarkson, T.B., Hughes, C.L., Jr., Morgan, T.M., and Burke, G.L. (1996) Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys. J Nutr. 126, 43-50.
4. Barnes, S. (1998) Evolution of the health benefits of soy isoflavones. Proc. Soc. Exp. Biol. Med. 217, 386-392.
5. Bischof, G., Illek, B., Reenstra, W.W., and Machen, T.E. (1995) Role for tyrosine kinases in carbachol-regulated Ca entry into colonic epithelial cells. Am. J. Physiol. 268, 154C-161C.
6. Cataldi, M., Taglialatela, M., Guerriere, S., Amoroso, S., Lombardi, G., di Renzo, G., and Annunziato, L. (1996) Protein-tyrosine kinases activate while protein-tyrosine phosphatases inhibit L-type calcium channel activity in pituitary GH3 cells. J. Biol. Chem. 271, 9441-9446.
7. Chen, S.-J., Li, H., Durand, J., Oparil, S., and Chen, Y.-F. (1996) Estrogen reduces myointimal proliferation after balloon injury of rat carotid artery. Circulation 93, 577-584.
8. Chiang, C.E., Chen, S.A., Chang, M.S., Lin, C.I., and Luk, H.N. (1996) Genistein directly inhibits L-type calcium currents but potentiates cAMP-dependent chloride currents in cardiomyocytes. Biochem. Biophys. Res. Commun. 223, 598-603.
9. Coward, L., Kirk, M., Albin, N., and Barnes, S. (1996) Analysis of plasma isoflavones by reversed-phase HPLC-multiple reaction monitoring-mass spectrometry. Clin. Chim. Acta 247, 121-142.
10. Fingerle, L. and Kraft, T. (1987) The induction of smooth muscle cell proliferation in vitro using an organ culture system. Inter. Angio. 6, 65-72.
11. Fotsis, T., Pepper, M., Adlercreutz, H., Hase, T., Montesano, R., and Schweigerer, L. (1995) Genestein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis. J. Nutr. 125, 790S-797S.
12. Fukumoto, Y., Shimokawa, H., Kozai, T., Kadokami, T., Kuwata, K., Owada, M.K., Shiraishi, T., Kuga, T., Egashira, K., and Takeshita, A. (1996) Tyrosine kinase inhibitor suppresses the (re) stenotic changes of the coronary artery after balloon injury in pigs. Cardiovasc. Res. 32, 1131-1140.
13. Grodstein, F., Stampfer, M.J., Colditz, G.A., Willett, W.C., Manson, J.E., Joffe, M., Rosner, B., Fuchs, C., Hankinson, S.E., Hunter, D.J., Hennekens, C.H., and Speizer, F.E. (1997) Postmenopausal hormone therapy and mortality. New Engl. J. Med. 336, 1769-1775.
14. Gustafsson, J.-A. (1997) Estrogen receptor β-Getting in on the action. Recent findings in mice hint that ERβ and not ERα mediate some of the vascular benefits of estrogen. Nature Medicine 3, 493-494.
15. Holm, P., Stender, S., Andersen, H.O., Hansen, B.F., and Nordestgard, B.G. (1997) Antiatherogenic effect of estrogen abolished by balloon catheter injury in cholesterol-clamped rabbits. Arterioscler. Thromb. Vasc. Biol. 17, 1504-1511.
16. Honore, E.K., Williams, J.K., Anthony, M.S., and Clarkson, T.B. (1997) Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques. Fertil. Steril. 67, 148-154.
17. Huang, J., Nasr, M., Kim, Y., and Matthews, H.R. (1992) Genistein inhibits protein histidine Kinase. J. Biol. Chem. 267, 15511-15515.
18. Hughes, C.L.j. (1987) Effects of phytoestrogens on GnRH-induced luteinizing hormone secretion in ovariectomized rats. Reprod. Toxicol. 1, 179-181.
19. Iafrati, M.D., Karas, R.H., Aronovitz, M., Kim, S., Sullivan, T.R., Lubahn, D.B., O'Donnell, T.F., Korach, K.S., and Mendelsohn, M.E. (1997) Estrogen inhibits the vascular injury response in receptor α-deficient mice. Nature Medicine 3, 545-548.
20. Jiang, C., Poole-Wilson, P.A., Sarrel, P.M., Mochizuki, S., Collins, P., and MacLeod. K.T. (1992) Effect of 17-beta-oestradiol on contraction. Ca-2+ current and intracellular free Ca-2+ in guinea-pig isolated cardiac myocytes. Brit. J. Pharmacol. 106, 739-745.
21. Jonas, J.C., Plant, T.D., Gilon, P., Detimary, P., Nenquin, M., and Henquin, J.C. (1995) Multiple effects and stimulation of insulin secretion by the tyrosine kinase inhibitor genistein in normal mouse islets. Br. J. Pharmacol. 114, 872-880.
22. Kanazawa, T., Osanai, T., Zhang, X.S., Uemura, T., Yin, X.Z., Onodera, K., Oike, Y., and Ohkubo, K. (1995) Protective effects of soy protein on the peroxidizability of lipoproteins in cerebrovascular diseases. J. Nutr. 125, 639S-646S.
23. Karas, R.H., Patterson, B.L., and Mendelsohn, M.E. (1994) Human vascular smooth muscle cells contain functional estrogen receptor. Circulation 89, 1943-1950.
24. Krasinski, K., Spyridopoulos, I., Asahara, T., Zee, R.v.d., Isner, J.M., and Losordo, D.W. (1997) Estradiol accelerates functional endothelial recovery after arterial injury. Circulation 95, 1768-1772.
25. Layman, D.L. and Titus, J.L. (1975) Synthesis of type I collagen by human smooth muscle cells in vitro. Lab. Invest. 33, 103-107.
26. Lin, A.L., Gonzalez, R., Carey, K.D., and Shain, S.A. (1986) Estradiol-17-beta affects estrogen receptor distribution and elevates progesterone receptor content in baboon aorta. Arteriosclerosis 6, 495-504.
27. Lindner, H.R. (1976) Occurence of anabolic agents in plants and their importance. Environ. Qual. Saf. Suppl. 5, 151-158.
28. Losordo, D.W., Kearney, M., Kim, E.A., Jekanowski, J., and Isner, J.M. (1994) Variable expression of the estrogen receptor in normal and atherosclerotic coronary arteries of premenopausal women. Circulation 89, 1501-1510.
29. Negrescu, E.V., de-Quintana, K.L., and Siess, W. (1995) Platelet shape change induced by thrombin receptor activation. Rapid stimulation of thyrosine phosphorylation of novel protein substrates through an integrin-and Ca(2+)-independent mechanism. J. Biol. Chem. 270, 1057-1061.
30. O'Keefe, J.H., Kim, S.C., Hall, R.R., Cochran, V.C., Lawhom, S.L., and McCallister, B.D. (1997) Estrogen replacement thrapy after coronary angioplasty in women. JACC 29, 1-5.
31. O'Brien, J.E., Peterson, E.D., Keeler, G.P., Berdan, L.G., Ohman, E.M., Faxon, D.P., Jacobs, A.K., Topol, E.J., and Califf, R.M. (1996) Relation between estrogen replacement therapy and restenosis after percutaneous coronary interventions. JACC 28, 1111-1118.
32. Paech, K., Webb, P., Kuiper, G.G.J.M., Nilsson, S., Gustafsson, J.-A., Kushner, P.J., and Scanlan, T.S. (1997) Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites. Science 277, 1508-1510.
33. Pauletto, P., Puato, M., Caroli, M.G., Casiglia, E., Munhambo, A.E., Cazzolato, G., Bon, G.B., Angeli, M.T., Galli, C., and Pessina, A.C. (1996) Blood pressure and atherogenic lipoprotein profiles of fish-diet and vegetarian villagers in Tanzania: the Lugalawa study. Lancet 348, 784-788.
34. Pelissero, C., Flouriot, G., Foucher, J.L., Bennetau, B., Dunoguès, J., Le-Gac, F., and Sumpter, J.P. (1993) Vitellogenin synthesis in cultured hepatocytes; an in vitro test for the estrogenic potency of chemicals. J. Steroid. Biochem. Molec. Biol. 44, 263-272.
35. Pennisi, E. (1997) Differing roles found for estrogen's two receptors. Science 277, 1439-1440.
36. Raines, E.W. and Ross, R. (1995) Biology of atherosclerotic plaque formation: possible role of growth factors in lesion development and the potential impact of soy. J. Nutr. 125, 624S-630S.
37. Reinli, K. and Block, G. (1996) Phytoestrogen content of foods - a compendium of literature values. Nutr. Cancer. 26, 123-148.
38. Rosenblum, E.R., Stauber, R.E., Van-Thiel, D.H., Campbell, I.M., and Gavaler, J.S. (1993) Assessment of the estrogenic activity of phytoestrogens isolated from bourbon and beer. Alcohol Clin. Exp. Res. 17, 1207-1209.
39. Rosenfeld, M.E. and Ross, R. (1990) Macrophage and smooth muscle cell proliferation in atherosclerotic lesions of WHHL and comparably hypercholesterolemic fat-fed rabbits. Arteriosclerosis 10, 680-687.
40. Ross, R. (1985) The pathogenesis of atherosclerosis - an update. N. Engl. J. Med. 314, 488-500.
41. Shi, Y., O'Brien, J.E., Jr., Fard, A., Mannion, J.D., Wang, D., and Zalewski, A. (1996a) Adventitial myofibroblasts contribute to neointimal formation in injured porcine coronary arteries. Circulation 94, 1655-1664.
42. Shi, Y., Pieniek, M., Fard, A., O'Brien, J.E., Jr., Mannion, J.D., and Zalewski, A. (1996b) Adventitial remodeling after coronary arterial injury. Circulation 93, 340-348.
43. Simons, L.A. (1986) Interrelations of lipids and lipoproteins with coronary artery disease mortality in 19 countries. Am. J. Cardial 57, 5G-10G.
44. Stampfer, M.J., Colditz, G.A., Willett, W.C., Manson, J.E., Rosner, B., Speizer, F.E., and Hennekens, C.H. (1991) Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study. N. Engl. J. Med. 11, 756-762.
45. Sullivan, J.M., Vander Zwag, R., Hughes, J.P., Maddock, V., Kroetz, F.W., Ramanathan, K.B., and Mirvis, D.M. (1990) Estrogen replacement and coronary artery disease. Effect on survival in postmenopausal women. Arch. Int. Med. 150, 2557-2562.
46. Vargas, R., Wroblewska, B., Rego, A., Hatch, J., and Ramwell, P.W. (1993) Oestradiol inhibits smooth muscle cell proliferation of pig coronary artery. Br. J. Pharmacol. 109, 612-617.
47. Venkov, C.D., Rankin, A.B., and Vaughan, D.E. (1996) Identification of authentic estrogen receptor in cultured endothelial cells. A potential mechanism for steroid hormone regulation of endothelial function. Circulation 94, 727-733.
48. Voisard, R., Baur, R., Hanke, H., Vogel, U., Mattfeldt, T., Höher, M., and Hombach, V. (1995) The effect of β-estradiol and progesterone on the proliferation of human endothelial and coronary smooth muscle cells in vitro. Eur. Heart J. 16, 278(Abstract).
49. Wei, H., Bowen, R., Cai, Q., Barnes, S., and Wang, Y. (1995) Anti-oxidant and antipromotional effects of the soybean isoflavone genistein. Proc. Soc. Exp. Biol. Med. 208, 124-130.
50. Whitten, P.L., Lewis, C., Russel, E., and Naftolin, F. (1995) Potential adverse effects of phytoestrogens. J. Nutr. 125, 771S-776S.
51. Wight, T.N. and Ross, R. (1975) Proteoglycans in primate arteries. II. Synthesis and secretion of glycosaminoglycans by arterial smooth muscle cells in culture. J. Cell Biol. 67, 675-686.
52. Xu, X., Wang, H.J., Murphy, P.A., Cook, L., and Hendrich, S. (1994) Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women. J. Nutr. 124, 825-832.