Fly immunity: Great expectations

Genome Biology

Volumn 1, Issue 1, 2000, Pages

  Medzhitov, Ruslan ^a   Janeway Jr , Charles ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; DROSOPHILA MELANOGASTER; GENETICS; GENOME; HUMAN; IMMUNOLOGY; REVIEW;

ANIMALS; DROSOPHILA MELANOGASTER; GENOME; HUMANS;

EID: 0033641313     PISSN: 14656906     EISSN: None     Source Type: Journal    
DOI: 10.1186/gb-2000-1-1-reviews106     Document Type: Article

References (17)

1. Adams MD. Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF et al.: The genome sequence of Drosophila mefonogoster. Science 2000, 287:2185-2195.
2. Rubin GM, Yandell MD, Wortman JR, Gabor Miklos GL, Nelson CR, Hariharan IK, Fortini ME, Li PW, Apweiler R, Fleischmann W et öl.: Comparative genomics of the eukaryotes. Science 2000, 287: 2204-2215.
3. Myers EW, Sutton GG, Delcher AL, Dew IM, Fasulo DP, Flanigan MJ, Kravitz SA, Mobarry CM, Reinert KH, Remington KA et ah. A whole-genome assembly of Drosophila. Science 2000, 287:21962204.
4. Janeway CA Jr: Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Bio/ 1989,54:1-13.
5. Meister M, Lemaitre B, Hoffmann JA: Antimicrobial peptide defense in Drosophila. β/oessoys 1997, 19:1019-1026.
6. Hoffmann JA, Kafatos FC, Janeway CA, Ezekowitz RA: Phylogenetic perspectives in innate immunity. Science 1999, 284:13131318.
7. Stahl PD, Ezekowitz RA: The mannose receptor is a pattern recognition receptor involved in host defense. Curr Opin Immunol 1998. 10:50-55.
8. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr: A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997, 388:394-397.
9. Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF. A family of human receptors structurally related to Drosophila Toll. Proc NatJAcad Sei USA 1998, 95:588-593.
10. Poltorak A, He X, Smirnova I, Liu MY, Huffel CV, Du X, Birdwell D, Alejos E, Suva M, Galanos C: Defective LPS signaling in C3H/HeJ and C57BUIOScCr mice: mutations in Tlr4 gene. Science 1998,282:2085-2088.
11. Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S: Differential rolesof TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999, 11:443-451.
12. Wright SD: Toll, a new piece in the puzzle of innate immunity [commentJ.] Exp Med 1999, 189:605-609.
13. Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyaké K, Kimoto M: MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll- like receptor 4. ] Exp Med 1999, 189: 1777-1782.
14. Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA: The dorsoventral regulatory gene cassette spatzle/ToII/cactus controls the potent antifungal response in Drosophila adults. Cell 1996, 86:973-983.
15. Anderson KV: Toll signaling pathways in the innate immune response. Curr Op/n Immunol 2000, 12:13-19.
16. Medzhitov R, Preston-Hurlburt P, Kopp E, Stadien A, Chen C, Ghosh S, Janeway CA Jr: MyD88 is an adaptor protein in the hToll/IL-I receptor family signaling pathways. Mol Cell 1998, 2:253-258.
17. Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A: The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor- associated factor 6 (TRAF6).J Exp Med 1998, 187:2097-2101.