Activating phosphorylation of the Kin28p subunit of yeast TFIIH by Cak1p

Molecular and Cellular Biology

Volumn 19, Issue 7, 1999, Pages 4774-4787

  Kimmelman, Jonathan ^a   Kaldis, Philipp ^a   Hengartner, Christoph J ^b,c   Laff, Geoffrey M ^a,d   Koh, Sang Seok ^b   Young, Richard A ^b   Solomon, Mark J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c PRINCETON UNIVERSITY   (United States)

^d Antigenics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE ACTIVATING KINASE; PHOSPHOTRANSFERASE; PROTEIN CAK1P; PROTEIN KIN28P; RNA POLYMERASE II; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR IIH; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE;

MAMMALIA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 0033036182     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.7.4774     Document Type: Article

References (67)

1. Adamczewski, J. P., M. Rossignol, J.-P. Tassan, E. A. Nigg, V. Moncollin, and J.-M. Egly. 1996. MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH. EMBO J. 15:1877-1884.
2. Akoulitchev, S., T. P. Mäkelä, R. A. Weinberg, and D. Reinberg. 1995. Requirement for TFIIH kinase activity in transcription by RNA polymerase II. Nature 377:557-560.
3. Akoulitchev, S., and D. Reinberg. 1998. The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7. Genes Dev. 12:3541-3550.
4. Albertyn, J., S. Hohmann, J. M. Thevelein, and B. A. Prior. 1994. GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway. Mol. Cell. Biol. 14:4135-4144.
5. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. 1995. Current protocols in molecular biology. J. Wiley & Sons, Inc., Boston, Mass.
6. Buck, V., P. Russell, and J. B. A. Millar. 1995. Identification of a cdk-activating kinase in fission yeast. EMBO J. 14:6173-6183.
7. Cismowski, M. J., G. M. Laff, M. J. Solomon, and S. I. Reed. 1995. KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity. Mol. Cell. Biol. 15:2983-2992.
8. Cross, F. R., and K. Levine. 1998. Molecular evolution allows bypass of the requirement for activation loop phosphorylation of the Cdc28 cyclin-dependent kinase. Mol. Cell. Biol. 18:2923-2931.
9. Dahmus, M. E. 1996. Reversible phosphorylation of the C-terminal domain of RNA polymerase II. J. Biol. Chem. 271:19009-19012.
10. Damagnez, V., T. P. Mäkelä, and G. Cottarel. 1995. Schizosaccharomyces pombe Mop1-Mcs2 is related to mammalian CAK. EMBO J. 14:6164-6172.
11. Desai, D., Y. Gu, and D. O. Morgan. 1992. Activation of human cyclin-dependent kinases in vitro. Mol. Biol. Cell 3:571-582.
12. Desai, D., H. C. Wessling, R. P. Fisher, and D. O. Morgan. 1995. The effect of phosphorylation by CAK on cyclin binding by CDC2 and CDK2. Mol. Cell. Biol. 15:345-350.
13. Devault, A., A.-M. Martinez, D. Fesquet, J.-C. Labbé, N. Morin, J.-P. Tassan, E. A. Nigg, J.-C. Cavadore, and M. Dorée. 1995. MAT1 ('menage à trois'), a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK. EMBO J. 14:5027-5036.
14. Ducommun, B., P. Brambilla, M.-A. Félix, B. R. Franza Jr., E. Karsenti, and G. Draetta. 1991. cdc2 phosphorylation is required for its interaction with cyclin. EMBO J. 10:3311-3319.
15. Espinoza, F. H., A. Farrell, H. Erdjument-Bromage, P. Tempst, and D. O. Morgan. 1996. A cyclin-dependent kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAK. Science 273:1714-1717.
16. Espinoza, F. H., A. Farrell, J. L. Nourse, H. M. Chamberlin, O. Gileadi, and D. O. Morgan. 1998. Cak1 is required for Kin28 phosphorylation and activation in vivo. Mol. Cell. Biol. 18:6365-6373.
17. Faye, G., M. Simon, J. G. Valay, D. Fesquet, and C. Facca. 1997. Rig2, a RING finger protein that interacts with the Kin28/Ccl1 CTD kinase in yeast. Mol. Gen. Genet. 255:460-466.
18. Feaver, W. J., O. Gileadi, and R. D. Kornberg. 1991. Purification and characterization of yeast RNA polymerase II transcription factor b. J. Biol. Chem. 266:19000-19005.
19. Feaver, W. J., N. L. Henry, Z. Wang, X. Wu, J. Q. Svejstrup, D. A. Bushnell, E. C. Friedberg, and R. D. Kornberg. 1997. Genes for Tfb2, Tfb3, and Tftb4 subunits of yeast transcription/repair factor IIH. J. Biol. Chem. 272:19319-19327.
20. Feaver, W. J., J. Q. Svejstrup, N. L. Henry, and R. D. Kornberg. 1994. Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK. Cell 79:1103-1109.
21. Fesquet, D., J.-C. Labbé, J. Derancourt, J.-P. Capony, S. Galas, F. Girard, T. Lorca, J. Shuttleworth, M. Dorée, and J.-C. Cavadore. 1993. The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues. EMBO J. 12:3111-3121.
22. Fisher, R. P., P. Jin, H. M. Chamberlin, and D. O. Morgan. 1995. Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase. Cell 83:47-57.
23. Fisher, R. P., and D. O. Morgan. 1994. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 78:713-724.
24. 1 and mitotic cyclins. Proc. Natl. Acad. Sci. USA 92:4651-4655.
25. Gietz, R. D., and A. Sugino. 1988. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74:527-534.
26. cdc2 function. EMBO J. 10:3297-3309.
27. Gu, Y., J. Rosenblatt, and D. O. Morgan. 1992. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J. 11:3995-4005.
28. Hengartner, C. J., V. E. Meyer, S. M. Liao, C. J. Wilson, S. S. Koh, and R. A. Young. 1998. Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases. Mol. Cell 2:43-54.
29. Hermand, D., A. Pihlak, T. Westerling, V. Damagnez, J. Vandenhaute, G. Cottarel, and R. P. Mäkelä. 1998. Fission yeast Csk1 is a CAK-activating kinase (CAKAK). EMBO J. 17:7230-7238.
30. Iavarone, A., and J. Massagué. 1997. Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15. Nature 387:417-422.
31. Kaldis, P., A. A. Russo, H. S. Chou, N. P. Pavletich, and M. J. Solomon. 1998. Human and yeast cdk-activating kinases (CAKs) display distinct substrate specificities. Mol. Biol. Cell 9:2545-2560.
32. Kaldis, P., A. Sutton, and M. J. Solomon. 1996. The cdk-activating kinase (CAK) from budding yeast. Cell 86:553-554.
33. Kato, J.-Y., M. Matsuoka, D. K. Storm, and C. J. Sherr. 1994. Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. Mol. Cell. Biol. 14:2713-2721.
34. Kolman, C. J., J. Toth, and D. K. Gonda. 1992. Identification of a portable determinant of cell cycle function within the carboxyl-terminal domain of the yeast CDC34 (UBC3) ubiquitin conjugating (E2) enzyme. EMBO J. 11: 3081-3090.
35. MO15 associates with a p36 subunit and requires both nuclear translation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes. EMBO J. 13:5155-5164.
36. Lees, E. 1995. Cyclin dependent kinase regulation. Curr. Opin. Cell Biol. 7:773-780.
37. Liao, S.-M., J. Zhang, D. A. Jeffery, A. J. Koleske, C. M. Thompson, D. M. Chao, M. Viljoen, H. J. J. van Vuuren, and R. A. Young. 1995. A kinase-cyclin pair in the RNA polymerase II holoenzyme. Nature 374:193-196.
38. Long, J. J., A. Leresche, R. W. Kriwacki, and J. M. Gottesfeld. 1998. Repression of TFIIH transcriptional activity and TFIIH-associated cdk7 kinase activity at mitosis. Mol. Cell. Biol. 18:1467-1476.
39. Mager, W. H., and J. C. S. Varela. 1993. Osmostress response of the yeast Saccharomyces. Mol. Microbiol. 10:253-258.
40. Mäkelä, T. P., J. D. Parvin, J. Kim, L. J. Huber, P. A. Sharp, and R. A. Weinberg. 1995. A kinase-deficient transcription factor TFIIH is functional in basal and activated transcription. Proc. Natl. Acad. Sci. USA 92:5174-5178.
41. Mäkelä, T. P., J.-P. Tassan, E. A. Nigg, S. Frutiger, G. J. Hughes, and R. A. Weinberg. 1994. A cyclin associated with the CDK-activating kinase MO15. Nature 371:254-257.
42. Maldonado, E., and D. Reinberg. 1995. News on initiation and elongation of transcription by RNA polymerase II. Curr. Opin. Cell Biol. 7:352-361.
43. Martinez, A.-M., M. Afshar, F. Martin, J.-C. Cavadore, J.-C. Labbé, and M. Dorée. 1997. Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity. EMBO J. 16:343-354.
44. Matsuoka, M., J.-Y. Kato, R. P. Fisher, D. O. Morgan, and C. J. Sherr. 1994. Activation of cyclin-dependent kinase 4 (Cdk4) by mouse MO15-associated kinase. Mol. Cell. Biol. 14:7265-7275.
45. Molz, L., and D. Beach. 1993. Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity. EMBO J. 12:1723-1732.
46. Morgan, D. O. 1997. Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu. Rev. Cell Dev. Biol. 13:261-291.
47. Morgan, D. O. 1996. The dynamics of cyclin dependent kinase structure. Curr. Opin. Cell Biol. 8:767-772.
48. Nonet, M., C. Scafe, J. Sexton, and R. Young. 1987. Eucaryotic RNA polymerase conditional mutant that rapidly ceases mRNA synthesis. Mol. Cell. Biol. 7:1602-1611.
49. Orphanides, G., T. Lagrange, and D. Reinberg. 1996. The general transcription factors of RNA polymerase II. Genes Dev. 10:2657-2683.
50. cdc2. EMBO J. 12:3123-3132.
51. Roy, R., J. P. Adamczewski, T. Seroz, W. Vermeulen, J.-P. Tassan, L. Schaeffer, E. A. Nigg, J. H. J. Hoeijmakers, and J.-M. Egly. 1994. The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor. Cell 79:1093-1101.
52. Russo, A. A., P. D. Jeffrey, and N. P. Pavletich. 1996. Structural basis of cyclin-dependent kinase activation by phosphorylation. Nat. Struct. Biol. 3:696-700.
53. Santos, R. C., N. C. Waters, C. L. Creasy, and L. W. Bergman. 1995. Structure-function relationship of the yeast cyclin-dependent kinase Pho85. Mol. Cell. Biol. 15:5482-5491.
54. Serizawa, H., T. P. Mäkelä, J. W. Conaway, R. C. Conaway, R. A. Weinberg, and R. A. Young. 1995. Association of Cdk-activating kinase subunits with transcription factor TFIIH. Nature 374:280-282.
55. Shiekhattar, R., F. Mermelstein, R. P. Fisher, R. Drapkin, B. Dynlacht, H. C. Wessling, D. O. Morgan, and D. Reinberg. 1995. Cdk-activating kinase complex is a component of human transcription factor TFIIH. Nature 374: 283-287.
56. Simon, M., B. Seraphin, and G. Faye. 1986. Kin28, a yeast split gene coding for a putative protein kinase homologous to CDC28. EMBO J. 5:2697-2701.
57. cdc2 activating kinase. Trends Biochem. Sci. 19:496-500.
58. MO15. EMBO J. 12:3133-3142.
59. Solomon, M. J., and P. Kaldis. 1998. Regulation of cdks by phosphorylation, p. 79-109. In M. Pagano (ed.), Results and problems in cell differentiation, vol. 22. Cell cycle control. Springer, Heidelberg, Germany.
60. cdc2 activation: identification of an activating kinase. Mol. Biol. Cell 3:13-27.
61. Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. Genes Dev. 10:1491-1502.
62. 2/M in the budding yeast cell cycle. Genetics 147:57-71.
63. Tassan, J.-P., M. Jaquenoud, A. M. Fry, S. Frutiger, G. J. Hughes, and E. A. Nigg. 1995. In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein. EMBO J. 14:5608-5617.
64. Thuret, J.-Y., J.-G. Valay, G. Faye, and C. Mann. 1996. Civ1 (CAK in vivo), a novel Cdk-activating kinase. Cell 86:565-576.
65. Valay, J.-G., M.-F. Dubois, O. Bensaude, and G. Faye. 1996. Cell, a cyclin associated with protein kinase Kin28, controls the phosphorylation of RNA polymerase II largest subunit and mRNA transcription. C. R. Acad. Sci. 319:183-189.
66. Valay, J.-G., M. Simon, M.-F. Dubois, O. Bensaude, C. Facca, and G. Faye. 1995. The KIN28 gene is required both for RNA polymerase II mediated transcription and phosphorylation of the Rpb1p CTD. J. Mol. Biol. 249:535-544.
67. Valay, J. G., M. Simon, and G. Faye. 1993. The Kin28 protein kinase is associated with a cyclin in Saccharomyces cerevisiae. J. Mol. Biol. 234:307-310.