Tumour necrosis factor-alpha (TNF-α) transcription and translation in the CD4+ T cell-transplanted scid mouse model of colitis

Clinical and Experimental Immunology

Volumn 116, Issue 3, 1999, Pages 415-424

  Williams, Amanda M ^a   Whiting, C V ^a   Bonhagen, K ^b   Reimann, J ^b   Bregenholt, S ^c   Claesson, M H ^c   Bland, P W ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF ULM   (Germany)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Macrophages; Scid colitis; Transcription; Translation; Tumour necrosis factor alpha

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL INFILTRATION; COLITIS; COMBINED IMMUNODEFICIENCY; DISEASE COURSE; DISEASE SEVERITY; HELPER CELL; IMMUNOCOMPETENCE; IMMUNOHISTOLOGY; IN SITU HYBRIDIZATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RNA PROBE;

ADOPTIVE TRANSFER; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; COLITIS; DISEASE MODELS, ANIMAL; MACROPHAGE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, SCID; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033034790     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.00915.x     Document Type: Article

References (55)

1. Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993; 75:253-61.
2. Kühn RL, Löhler J, Rennick D, Rajewsky K, Müller W. Interleukin-10-deficient mice develop chronic enterocolitis
3. Mombaerts P, Mizoguchi E, Grusby MJ, Glimeher LH, Bhan AK, Tonegawa S. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 1993; 75:275-82.
4. + T cells and proinflammatory Th1-type cytokines. J Immunol 1997; 158:1068-77.
5. + T cells. J Exp Med 1993; 178:237-44.
6. + T cells induce or protect against chronic intestinal inflammation in C.B-17 Scid mice. Int Immunol 1993; 5:1461-71.
7. + T cells are important for the balance between protective and pathogenic cell mediated immunity. J Exp Med 1994; 179:589-600.
8. + T cells. Am J Pathol 1996; 148:1503-15.
9. + T cells in the pathogenesis of murine inflammatory bowel disease. Eur J Immunol 1994; 24:2803-12.
10. + αβ T cells in scid mice with colitis. Eur J Immunol 1996; 26:3074-83.
11. + T cells. Res Immunol 1904; 145:332-7.
12. + alpha beta T cells in the colonic lamina propria of scid mice with colitis. Eur J Immunol 1996; 26:1156-63.
13. + T cells into scid mice chronically treated with soluble IL-4 receptor does not prevent engraftment of IL-4-producing T cells. Scand J Immunol 1993; 38:57-64.
14. Bregenholt S, Claesson MH. Increased intracellular Th1 cytokines in scid mice with inflammatory bowel disease. Eur J Immunol 1998; 28:379-89.
15. + T cells. Immunity 1994; 1:553-62.
16. Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A. Interleukin 10 inhibits cytokine production by activated macrophage. J Immunol 1991; 147:3815-22.
17. + T cell subset inhibits antigen specific T cell responses and prevents colitis. Nature 1997; 389:737-41.
18. Asseman C, Powrie F. Interleukin 10 is a growth factor for a population of regulatory T cells. Gut 1998; 42:157-8.
19. + T cells. J Exp Med 1996; 183:2669-74.
20. MacDonald TT, Hutchings P, Choy MY, Murch S, Cooke A. Tumour necrosis factor α and inlerferon γ production measured at the single cell level in normal and inflamed human intestine. Clin Exp Immunol 1990; S1:301-5.
21. Murch S, Lambkin VA, Savage MO, Walker-Smith JA, MacDonald TT. Serum concentrations of tumour necrosis factor α in childhood chronic inflammatory bowel disease. Gut 1991; 32:913-7.
22. Murch SH, Braegger CP, Walker-Smith JA, MacDonald TT. Location of tumour necrosis factor α by immunohistochemistry in chronic inflammatory bowel disease. Gut 1993; 34:1705-9.
23. Isaacs KL, Sartor LB, Haskill JS. Cytokine mRNA profiles in inflammatory bowel disease mucosa detected by PCR amplification. Gastroenterol 1992; 103:1587-95.
24. Stevens C, Walz G, Singaram C et al. Tumour necrosis factor-α, interleukin-1β, and interleukin-6 expression in inflammatory bowel disease. Dig Dis Sci 1992; 37:818.
25. Reimund JM, Dumont S, Muller CD, Kenney JS, Kedinger M, Baumann R, Poindron P, Duclos B. In vitro effects of oxpentifylline on inflammatory cytokine release in patients with IBD. Gut 1997; 40:475-80.
26. Bauditz J, Haemling J, Ortner M, Lochs H, Raedler A, Schreiber S. Treatment with tumour necrosis factor inhibitor oxpentifylline does not improve corticosteroid dependant chronic active Crohn's disease. Gut 1997; 40:470-4.
27. Katz J, Geraci K. An open trial of pentoxifylline for active Crohn's disease. Gastroenterol 1997; 112:A1009.
28. Stack WA, Man SD, Roy AJ et al. Randomised controlled trial of CDP571 antibody to tumour necrosis factor-α in Crohn's disease. Lancet 1997; 349:521-4.
29. van Dullemen HM, van Deventer SJH, Hommes DW, Bijl HA, Jansen J, Tytgat GNJ, Woody J. Treatment of Crohn's disease with anti-tumour necrosis factor chimeric monoclonal antibody (cA2). Gastroenterol 1995; 109:129-35.
30. Targan SR, Hanauer SB, van Deventer SJH et al. A short-term study of chimeric monoclonal antibody cA2 to tumour necrosis factor-α for Crohn's disease. N Engl J Med 1997; 337:1029-35.
31. Rutgeerts P, D'Haens G, van Deventer SJH et al. Retreatment with anti-TNF-α chimeric antibody (cA2) effectively maintains cA2-induced remission in Crohn's disease. Gastroenterol 1997; 112:A1078.
32. Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 1977; 74:5463-7.
33. Sanger F, Coulson AR, Barrell BG, Smith AJM, Roe BA. Cloning in single stranded bacteriophage as an aid to rapid DNA sequencing. J Mol Biol 1980; 143:161-78.
34. Ezekowitz RAB, Austyn J, Stahl P, Gordon S. Surface properties of BCG-activated mouse macrophages; reduced expression of mannose specific endocytosis, Fc receptors, and antigen F4/80 accompanies induction of Ia. J Exp Med 1981; 154:60-76.
35. Hume DA, Robinson AP, Macpherson GG, Gordon S. The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of the antigen F4/80; relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs. J Exp Med 1983; 158:1522-36.
36. McKnight AJ, Macfarlane AJ, Dris P, Turley L, Willis C, Gordon S. Molecular cloning of F4/80, a macrophage-restricted cell surface glycoprotein with homology to the G-protein linked transmembrane 7 hormone receptor family. J Biol Chem 1996; 271:486-9.
37. Haidl ID, Jefferies WA. The macrophage cell surface glycoprotein F4/ 80 is a highly glycosylated proteoglycan. Eur J Immunol 1996; 26:1139-46.
38. Woywodt A, Neustock P, Kruse A, Schwarting K, Ludwig D, Stange EF, Kirchner H. Cytokine expression in intestinal mucosal biopsies. In situ hybridisation of the mRNA for interleukin-1β, interleukin-6 and tumour necrosis factor-α in inflammatory bowel disease. Eur Cytokine Netw 1994; 5:387-95.
39. Cappello M, Keshav S, Prince C, Jewell DP, Gordon S. Detection of mRNAs for macrophage products in inflammatory bowel disease by in situ hybridisation. Gut 1992; 33:1214-9.
40. Neurath MF, Fuss I, Pasparakis M et al. Predominant pathogenic role of tumour necrosis factor in experimental colitis in mice. Eur J Immunol 1997; 27:1743-50.
41. hi CD4 T cells from IFN-γ knockout mice do not induce wasting disease. JAI 1997; 10:455-9.
42. Vassali P. The pathophysiology of tumour necrosis factors. Ann Rev Immunol 1992; 10:411-52.
43. Spriggs DR, Imamura K, Rodriguez C, Sariban E, Kufe D. Tumour necrosis factor expression in human epithelial tumour cell lines. J Clin Invest 1988; 81:455-60.
44. Greten TF, Moeller J, Feldmeier H, Eigler A, Endres S. Synthesis of tumour necrosis factor-α in tissue culture of rat caecum: lack of suppression by phosphodiesterase inhibitors and prostanoids. Eur J Gast Hepat 1996; 8:679-84.
45. Jung HC, Eckmann L, Yang S-K, Panja A, Fierer J, Morzycka- Wroblewska B, Kagnoff MF. A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J Clin Invest 1995; 95:55-65.
46. Mohler KM, Butler LD. Quantitation of cytokine mRNA levels utilising the reverse transcriptase polymerase chain reaction following primary antigen specific sensitisation in vivo. I. Verification of linearity, reproducibility and specificity. Mol Immunol 1991; 28:437-47.
47. di Giovine FS, Malawista SE, Thornton E, Duff GW. Urate crystals stimulate production of tumour necrosis factor alpha from human blood monocytes and synovial cells: cytokine mRNA and protein kinetics, and cellular distribution. J Clin Invest 1991; 87:1375-81.
48. Caput D, Beutler B, Hartog K, Thayer R, Brown-Shimer S, Cerami A. Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators. Proc Natl Acad Sci USA 1986; 83:1670-4.
49. Shaw G, Kamen R. A conserved AU sequence from the 3′-untranslated region of GM-CSF mRNA mediates selective mRNA degradation
50. Bohjanen PR, Petryniak B, June CH, Thompson CB, Lindsten T. An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3′-untranslated region of lymphokine mRNA. Mol Cell Biol 1991; 1:3288-95.
51. Plevy SE, Targan SR, Rotter JI, Toyoda H. Tumour necrosis factor (TNF) microsatellite associations within HLA-DR2 patients define Crohn's disease (CD) and ulcerative colitis (UC)-specific genotypes. Gastroenterol 1994; 106:A754.
52. Guy-Grand D, DiSanto JP, Henchoz P, Malassis-Seris M, Vassalli P. Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-γ, TNF-α) in the induction of epithelial cell death and renewal. Eur J Immunol 1998; 28:730-44.
53. Pender SLF, Tickle SP, Docherty AJP, Howie D, Wathen NC, MacDonald TT. A major role for matrix metalloproteinases in T cell injury in the gut. J Immunol 1997; 158:1582-90.
54. Cordone MH, Salvesen GS, Widman C, Johnson G, Frisch SM. The regulation of anoikis: MEKK-I activation requires cleavage by caspases. Cell 1997; 90:315-23.
55. Nathens AB, Rotstein OD, Dackiw APB, Marshall JC. Intestinal epithelial cells down-regulate macrophage tumour necrosis factor a secretion: a mechanism for immune homeostasis in the gut associated lymphoid tissue. Surgery 1995; 118:343-51.