High incidence of sudden death with conduction system and myocardial disease due to lamins A and C gene mutation

PACE - Pacing and Clinical Electrophysiology

Volumn 23, Issue 11 I, 2000, Pages 1661-1666

  BÉCANE, Henri Marc ^a   Bonne, GisÈle ^b   Varnous, Shaida ^b   Muchir, Antoine ^b   Ortega, VÉronique ^a   Hammouda, El Hadi ^a   Urtizberea, J Andoni ^a   Lavergne, Thomas ^c   Fardeau, Michel ^a,b   Eymard, Bruno ^a   Weber, Simon ^c   Schwartz, Ketty ^b   Duboc, Denis ^a,b,c  

^a Institut de Myologie   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c Université Paris Descartes   (France)

Author keywords

Arrhythmia; Familial cardiomyopathy; Lamins A and C; LMNA gene; Nonsense mutation; Sudden death

Indexed keywords

LAMIN A; LAMIN C;

ADULT; ARTICLE; ATRIOVENTRICULAR CONDUCTION; AUTOSOMAL DOMINANT DISORDER; CARDIOMYOPATHY; CHROMOSOME 1Q; EMERY DREIFUSS MUSCULAR DYSTROPHY; FEMALE; GENE MUTATION; HEART ARRHYTHMIA; HEART ELECTROPHYSIOLOGY; HEART LEFT VENTRICLE FUNCTION; HEART TRANSPLANTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MYOCARDIAL DISEASE; NONSENSE MUTATION; SUDDEN DEATH;

ADOLESCENT; ADULT; AGED; ARRHYTHMIA; CARDIOMYOPATHIES; COMORBIDITY; DEATH, SUDDEN, CARDIAC; DNA MUTATIONAL ANALYSIS; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; FRANCE; GENES, DOMINANT; HEART CONDUCTION SYSTEM; HUMANS; INCIDENCE; LAMINS; MALE; MIDDLE AGED; MUTATION; NUCLEAR PROTEINS; PEDIGREE; PHENOTYPE; RETROSPECTIVE STUDIES;

EID: 0033636387     PISSN: 01478389     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9592.2000.01661.x     Document Type: Article

References (27)

1. Sudden death in hypertrophic cardiomyopathy A profile of 78 patients
2. Right ventricular cardiomyopathy and sudden death in young people
3. Clinical characteristics of sudden death victims in heritable (chromosome 1p1-1q1) conduction and myocardial disease
4. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation
5. Genetic and molecular basis of cardiac arrhythmias: Impact on clinical management parts I and II
6. Genetic and molecular basis of cardiac arrhythmias: Impact on clinical management part III
7. The frequency of familial dilated cardiomyopathy in a series of patients with idiopathic dilated cardiomyopathy
8. Familial dilated cardiomyopathy: Cardiac abnormalities are common in asymptomatic relatives and may represent early disease
9. Frequency and phenotypes of familial dilated cardiomyopathy
10. Actin mutations in dilated cardiomyopathy, a heritable form of heart failure
11. Desmin mutation responsible for idiopathic dilated cardiomyopathy
12. Genetic basis of cardiomyopathy
13. A gene defect that causes conduction system disease and dilated cardiomyopathy maps to chromosome 1p1-1q1
14. Investigation of a family with autosomal dominant dilated cardiomyopathy defines a novel locus on chromosome 2q14-q22
15. Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy
16. Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease
17. 60th ENMC International Workshop: Non X-linked Emery-Dreifuss Muscular Dystrophy, 5-7 June 1998
18. Should ICDs be implanted in all patients with dilated cardiomyopathy and unexplained syncope?
19. Treatment and prevention of sudden cardiac death: Effect of recent clinical trials
20. Familial hypertrophic cardiomyopathy: From mutations to functional defects
21. Familial dilated cardiomyopathy: Evidence for genetic and phenotypic heterogeneity
22. Emery-Dreifuss syndrome
23. Lamin A/C gene mutation associated with dilated cardiomyopathy with variable skeletal muscle involvement
24. Missense mutations in desmin associated with familial cardiac and skeletal myopathy
25. Brief report: Deletion of the dystrophin muscle-promoter region associated with X-linked dilated cardiomyopathy
26. Cardiac involvement in carriers of Duchenne and Becker muscular dystrophy
27. Signs and symptoms of Duchenne muscular dystrophy and Becker muscular dystrophy among carriers in The Netherlands: A cohort study