Increase in systolic blood pressure and catecholamine level during hyperinsulinemia in a placebo-controlled euglycemic clamp in healthy subjects

Experimental and Clinical Endocrinology and Diabetes

Volumn 108, Issue 8, 2000, Pages 498-505

  Kern, W ^a   Fittje, A ^a   Fohr, W ^a   Kerner, W ^a   Born, J ^a   Fehm, H L ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Central nervous effects; Epinephrine; Healthy subjects; Hyperinsulinemia; Hypertension; Norepinephrine

Indexed keywords

ADRENALIN; CATECHOLAMINE; GLUCOSE; INSULIN; NORADRENALIN;

ADRENALIN BLOOD LEVEL; ADULT; ARTICLE; CATECHOLAMINE BLOOD LEVEL; CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN INFUSION; MALE; NORADRENALIN BLOOD LEVEL; NORMAL HUMAN; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE;

ADOLESCENT; ADULT; BLOOD GLUCOSE; DIASTOLE; EPINEPHRINE; GLUCOSE CLAMP TECHNIQUE; HEART RATE; HUMANS; HYPERINSULINISM; INFUSIONS, INTRAVENOUS; INSULIN; KINETICS; MALE; NOREPINEPHRINE; PLACEBOS; REFERENCE VALUES; SYSTOLE;

EID: 0033635326     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2000-11003     Document Type: Article

References (48)

1. Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans
2. The vasodilator action of insulin. Implications for the insulin hypothesis of hypertension
3. Nocturnal blood pressure elevation in patients with type 1 diabetes receiving intensive insulin therapy compared with that in patients receiving conventional insulin therapy
4. Reduced capacity and affinity of skeletal muscle for insulin-mediated glucose uptake in non-insulin-dependent diabetic subjects: Effects of insulin therapy
5. Hypoglycemic symptoms and decreased β-adrenergic sensitivity in insulin-dependent diabetic patients
6. The sympathetic response to euglycemic hyperinsulinaemia: Evidence from microelectrode nerve recordings in healthy subjects
7. Insulin-induced enhancement of uptake of noradrenaline in atrial strips
8. Lack of relationship between sympathetic nervous system activity, measured by two circulating markers, and blood pressure in diabetic and nondiabetic subjects
9. An inconsistent relationship between insulin and blood pressure in three Pacific island populations
10. The cardiovascular risk profile of adolescents with insulin-dependent diabetes mellitus
11. Evidence that the brain of the conscious dog is insulin sensitive
12. Brain of the conscious dog is sensitive to physiological changes in circulating insulin
13. Adrenomedullary hyperactivity in type I diabetic patients before and during continuous subcutaneous insulin treatment
14. High urinary excretion of adrenaline in insulin dependent diabetic subjects
15. Hyperinsulinemia as an independent risk factor for ischemic heart disease
16. Asymptomatic diabetes mellitus in normal weight subjects with hypertension. Studies on glucose tolerance, serum insulin and nonesterified fatty acids in essential hypertension
17. Sex differences in the coronary heart disease risk profile: A possible role for insulin
18. Hyperinsulinemia and elevated blood pressure: Cause, confounder, or coincidence
19. Relative roles of insulin and hypoglycaemia on induction of neuroendocrine responses to, symptoms of, and deterioration of cognitive function in hypoglycaemia in male and female humans
20. Insulin resistance in essential hypertension
21. Renal and cardiovascular effects of exogenous insulin in healthy volunteers
22. Intravenous insulin causing loss of intravascular water and albumin and increased adrenergic nervous activity in diabetics
23. Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after 1 episode of hypoglycemia in nondiabetic humans
24. Re: Hyperinsulinemia and elevated blood pressure: Cause, confounder, or coincidence
25. Sympathetic hyperacitvity and coronary risk in hypertension
26. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM
27. Evidence against a humoral control mechanism in adrenal catecholamine secretion during insulin-induced hypoglycemia
28. Insulin mediated glucose metabolism in the relationship between dietary intake and sympathetic nervous system activity
29. Abnormal sympathetic overactivity evoked by insulin in the skeletal muscle of patients with essential hypertension
30. Hypertension and hyperinsulinaemia: A relation in diabetes but not essential hypertension
31. Evidence against the hypothesis that hyperinsulinemia increases sympathetic nervous systen activity in man
32. The glucose clamp procedure activates the sympathetic nervous system even in the absence of hyperinsulinemia
33. Hyperinsulinaemia: A link between hypertension, obesity and glucose intolerance
34. An epidemiological test of the hyperinsulinemia-hypertension hypothesis
35. Mechanisms of insulin action on sympathetic nerve activity
36. Physiological hyperinsulinaemia increases distal artery systolic blood pressure without changing proximal blood pressure
37. Nocturnal blood pressure elevation is related to adrenomedullary hyper-activity, but not to hyperinsulinemia, in nonobese normoalbuminuric type 1 diabetes
38. The artificial beta cell-acontinuous control of blood sugar by external regulation of insulin infusion (glucose controlled insulin infusion system)
39. A role for insulin in the aetiology and course of hypertension?
40. Hypertension and associated metabolic abnormalities - The role of insulin resistance and the sympathoadrenal system
41. A role for alpha-adrenergic receptors in abnormal insulin secretion in diabetes mellitus
42. Effect of insulin and glucose infusions on sympathetic nervous system activity in normal man
43. Effect of insulin on central catecholamines
44. Effects of insulin on vascular tone and sympathetic nervous system in NIDDM
45. Circumventricular organs: Receptors and mediators of direct peptide hormone action on brain
46. Hormonal responses to exhausting physical exercise: The role of predictability and controllability of the situation
47. Increased integrated concentration of norepinephrine, epinephrine, aldosterone, and growth hormone in patients with uncontrolled juvenile diabetes mellitus
48. Elevated levels of leptin and insulin but not of TNF alpha are associated with hypertension in type 2 diabetic males