Presence of the DRB4*0103102N null allele in different DRB1*04-positive individuals

Tissue Antigens

Volumn 55, Issue 1, 2000, Pages 37-43

  Voorter, C E M ^a   Lardy, N M ^b   Van Den Berg Loonen, Ella M ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b CENTRAL LABORATORY   (Netherlands)

Author keywords

DRB1*04; DRB4*0103102N; HLA class II; Null allele; Sequence based typing

Indexed keywords

HLA ANTIGEN CLASS 2; HLA DR ANTIGEN; HLA DR4 ANTIGEN; HLA DR53 ANTIGEN; HLA DR7 ANTIGEN; PRIMER DNA; UNCLASSIFIED DRUG; DNA; HLA DRB4; HLA-DRB1 ANTIGEN; HLA-DRB4;

ALLELE; ANTIBODY SPECIFICITY; ARTICLE; CLINICAL ARTICLE; FAMILY STUDY; FEMALE; HAPLOTYPE; HLA TYPING; HUMAN; HUMAN CELL; KIDNEY DISEASE; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEROLOGY; CHEMISTRY; GENE; GENETICS; NULL CELL; PEDIGREE;

ALLELES; DNA; DNA PRIMERS; GENES, MHC CLASS II; HAPLOTYPES; HLA-DR ANTIGENS; HUMANS; LYMPHOCYTES, NULL; PEDIGREE;

EID: 0033629674     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0039.2000.550106.x     Document Type: Article

References (29)

1. 1. Kappes D, Strominger JL. Human class II major histocompatibility complex genes and proteins. Annu Rev Biochem 1988: 57: 991-1028.
2. 2. Bodmer JG, Marsh SGE, Albert ED et al. Nomenclature for factors of the HLA system, 1991. Tissue Antigens 1992: 39: 161-73.
3. 3. Perrier P, Leotard B, Henry MA. A novel HLA haplotype containing a DRB5 gene associated with the DRB1*0103 allele. Tissue Antigens 1993: 42: 518-21.
4. 4. Van den Berg-Loonen EM. AHS11: HLA-DR2 (DR15, DR16), DR51. In: Charron D, ed. Genetic Diversity of HLA: Functional and medical implications. Sevres: EDK, 1997: 91-4.
5. 5. Wisecarver J, Shepherd S, Beisel K, Rubocki R. Serologic and molecular studies of two kindreds expressing recombinant HLA DR1/DR2 haplotypes. Tissue Antigens 1993: 41: 148-54.
6. 6. Tautz C, Marsh DG, Baur X. A novel HLA-haplotype containing a DRB5 gene not associated with DRB1*15 or DRB1*16 alleles. Tissue Antigens 1992: 39: 91-4.
7. 7. Bidwell JL, Bidwell EA, Dupont E et al. Molecular characterization of a recombinant HLA-DR1/DR2 haplotype. Hum Immunol 1992: 33: 289-93.
8. 8. Oudshoorn M, du Toit ED, Martell RW. New HLA-DR2-related specificities detected in South African Blacks and individuals of mixed ancestry. Tissue Antigens 1990: 35: 211-6.
9. 9. Young NT, Darke C. Molecular characterization of the HLA-DR2LUM haplotype. Tissue Antigens 1994: 43: 28-33.
10. 10. Voorter CEM, Roeffaers HET, du Toit ED, van den Berg-Loonen EM. The absence of DR51 in a DRB5-positive individual DR2ES is caused by a null allele (DRB5*0108N). Tissue Antigens 1997: 50: 326-33.
11. 11. Sutton VR, Kienzle BK, Knowles RW. An altered splice site is found in the DRB4 gene that is not expressed in HLA-DR7,Dw11 individuals. Immunogenetics 1989: 29: 317-22.
12. 12. Robbins FM, Hurley CK, Yao TTH et al. Diversity associated with the second expressed HLA-DRB locus in the human population. Immunogenetics 1997: 46: 104-10.
13. 13. Knowles RW, Flomenberg N, Horibe K, Winchester R, Radka SF, Dupont B. Complexity of the supertypic HLA-DRw53 specificity: two distinct epitopes differentially expressed on one or all of the DR β-chains depending on the HLA-DR allotype. J Immunol 1986: 137: 2618-26.
14. 14. Matsuyama T, Schwenzer J, Silver J, Winchester R. Structural relationships between the DRβ1 and DRβ2 subunits in DR4, 7 and w9 haplotypes and the DRw53 (MT3) specificity. J Immunol 1986: 137: 934-40.
15. 15. Lardy NM, van der Horst AR, van de Weerd MJ, de Waal LP, Bontrop RE. HLA-DRB4 gene encoded HLA-DR53 specificity segregating with the HLA-DR7, -DQ9 haplotype: unusual association. Hum Immunol 1998: 59: 115-8.
16. 16. Lardy NM, van der Horst AR, van den Berg-Loonen EM, Bontrop ER, de Waal LP. Fine specificity of the alloantiserum MSD-51: epitope mapping of HLA-DRw53 determinants. Hum Immunol 1991: 32: 65-71.
17. 17. Bein G, Gläser R, Kirchner H. Rapid HLA-DRB1 genotyping by nested PCR amplification. Tissue Antigens 1992: 39: 68-73.
18. 18. Savelkoul PHM, De Bruyn-Geraets DP, Van den Berg-Loonen EM. High resolution HLA-DRB1 SSP typing for cadaveric donor transplantation. Tissue Antigens 1995: 45: 41-8.
19. 19. Voorter CEM, Rozemuller EH, De Bruyn-Geraets D, Van der Zwan A-W, Tilanus MGJ, Van den Berg-Loonen EM. Comparison of DRB sequence based typing using different strategies. Tissue Antigens 1997: 49: 471-6.
20. 20. Voorter CEM, de Bruyn-Geraets D, van den Berg-Loonen EM. High-resolution HLA typing for the DRB3/4/5 genes by sequence-based typing. Tissue Antigens 1997: 50: 283-90.
21. 21. Voorter CEM, Kik MC, van den Berg-Loonen EM. High-resolution HLA typing for the DQB1 gene by sequence-based typing. Tissue Antigens 1998: 51: 80-7.
22. 22. Naruse RK, Ando R, Nose Y et al. HLA-DRB4 genotyping by PCR-RFLP: diversity in the associations between HLA-DRB4 and DRB1 alleles. Tissue Antigens 1997: 49: 152-9.
23. 23. O'Neill CM, Bunce M, Welsh KI. Detection of the DRB4 null gene, DRB4*0101102N, by PCR-SSP and its distinction from other DRB4 genes. Tissue Antigens 1996: 47: 245-8.
24. 24. De-Canck I, Demanet C, Mersch G et al. Characterization of a new DRB4 allele (DRB4*0104). Tissue Antigens 1996: 48: 213-6.
25. 25. Buyse IM, Couture C, Sargent MD, Hashemi-Tavoularis S. A three-step allele-level DRB1-DRB3-DRB4-DRB5 genotyping assay using polymerase chain reaction with immobilized sequence-specific oligoprobes. Tissue Antigens 1997: 50: 291-302.
26. 26. Moses JH, Marsh SGE, Ikeda H, Trowsdale J, Bodmer J. A novel method of screening alloantisera in a microcytotoxicity assay using human mutant cells transfected with HLA-Class II alleles. Tissue Antigens 1992: 39: 156-8.
27. 27. Gregersen PK, Kao H, Nunez-Roldan A, Hurley CK, Karr RW, Silver J. Recombination sites in the HLA class II region are haplotype dependent. J Immunol 1988: 141: 1365-8.
28. 28. Wucherpfennig KW, Sette A, Southwood S et al. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J Exp Med 1994: 179: 279-90.
29. 29. Rosen-Bronson S, Jaraquemada D. On the relative immunogenicity of DR alloantigens: T cell recognition of HLA-DR2a and HLA-DR2b. Hum Immunol 1991: 30: 215-21.