The absence of DR51 in a DRB5-positive individual DR2ES is caused by a null allele (DRB5*0108N)

Tissue Antigens

Volumn 50, Issue 4, 1997, Pages 326-333

  Voorter, C E M ^a   Roeffaers, H E T ^a   Du Toit, E D ^b   Van Den Berg Loonen, E M ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Lab for Tissue Immunol Observ   (South Africa)

Author keywords

DR2ES; HLA DRB5; Null allele; Sequencing

Indexed keywords

COMPLEMENTARY DNA; DNA; HLA DR ANTIGEN;

ALLELE; ARTICLE; CASE REPORT; EXON; FEMALE; GENE SEQUENCE; GENETIC DISORDER; HLA TYPING; HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STOP CODON;

EID: 0030882377     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-0039.1997.tb02882.x     Document Type: Article

References (25)

1. Bodmer JG, Pickbourne P, Richards S. In: Bodmer WF, Batchelor JR, Bodmer JG, Festenstein H, Morris PJ, ed. Histocompatibility testing 1977. Copenhagen: Munksgaard, 1977: 35.
2. Batchelor JR, Curtoni S, Mervart H, Noreen H, Davey NJ, Moses JH, Amoroso A. Antigen Society #22 report (DR2). In: Dupont B, ed. Immunology of HLA, vol 1. New York: Springer-Verlag, 1989: 240-2.
3. Oudshoorn M, du Toit ED, Martell RW. New HLA-DR2-related specificities detected in South African Blacks and individuals of mixed ancestry. Tissue Antigens 1990: 35: 211-6.
4. Mervart M, Perkins HA, Van den Berg-Loonen EM et al. Antigen Society no. 202, part 1: HLA-DR2. In: Tsuji K, Aizawa M, Sasazuki T, ed. HLA 1991 vol 1. Oxford: Oxford University Press, 1992: 349-54.
5. Schreuder GMT, Van den Berg-Loonen PM, Verduyn W et al. Increasing complexity of HLA-DR2 as detected by serology and oligonucleotide typing. Hum Immunol 1991: 32: 141-9.
6. Bodmer JG, Marsh SGE, Parham P et al. Nomenclature for factors of the HLA system 1989. Tissue Antigens 1990: 35: 1-8.
7. Böhme J, Andersson M, Andersson G, Möller E, Peterson PA, Rask L. HLA-DR β genes vary in number between different DR specificities, whereas the number of DQ β genes is constant. J Immunol 1985: 135: 2149-55.
8. Andersson G, Larhammar D, Widmark E, Servenius B, Peterson PA, Rask L. Class II genes of the human major histocompatibility complex: organization and evolutionary relationship of the DRβ genes. J Biol Chem 1987: 262: 8748-58.
9. Bodmer JG, Marsh SGE, Albert ED et al. Nomenclature for factors of the HLA system, 1996. Tissue Antigens 1997: 49: 297-321.
10. Tiercy J-M, Jeannet M, Mach B. Oligonucleotide typing analysis for the linkage disequilibrium between the polymorphic DRB1 and DRB5 loci in DR2 haplotypes. Tissue Antigens 1991: 37: 161-4.
11. Bontrop RE, Schreuder GMT, Elferink DG, Mikulski MMA, Geerse R, Giphart MJ. Molecular, serologic and functional evidence for an apparent HLA-DR triplet. J Immunol 1986: 137: 211-6.
12. Perrier P, Leotard B, Henry MA. A novel HLA haplotype containing a DRB5 gene associated with the DRB1*0103 allele. Tissue Antigens 1993: 42: 518-21.
13. Van den Berg-Loonen EM, Bignon JD, Du Toit E et al. AHS11: HLA-DR2 (DR15, DR16), DR51. In: Charron D, ed. Genetic diversity of HLA: functional and medical implications. Sevres: EDK (in press).
14. Wisecarver J, Shepherd S, Beisel K, Rubocki R. Serologic and molecular studies of two kindreds expressing recombinant HLA DR1/DR2 haplotypes. Tissue Antigens 1993: 41: 148-54.
15. Tautz C, Marsh DG, Baur X. A novel HLA-haplotype containing a DRB5 gene not associated with DRB1*15 or DRB1*16 alleles. Tissue Antigens 1992: 39: 91-4.
16. Bidwell JL, Bidwell EA, Dupont E et al. Molecular characterization of a recombinant HLA-DR1/DR2 haplotype. Hum Immunol 1992: 33: 289-93.
17. Salazar M, Granja CB, Selvakumar A et al. New HLA-DR haplotypes containing the DRB6 pseudogene. Tissue Antigens 1996: 48: 575-9.
18. Nesci S, Talevi N, Andreani M, Manna M, Iliescu A, Lucarelli G. An unusual DRB1*1503 haplotype without a detectable DRB5 locus in a black African family. Tissue Antigens 1997: 49: 53-5.
19. Young NT, Darke C. Molecular characterization of the HLA-DR2LUM haplotype. Tissue Antigens 1994: 43: 28-33.
20. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988: 16: 1215.
21. Voorter C, Savelkoul P, Bielefeld M, Van den Berg-Loonen EM. Sequencing based typing for HLA-class II genes with an ALF automated sequencer. In: Tilanus MGJ, Eliaou JF, ed. Technical handbook sequencing based typing. Twelfth International Histocompatibility Workshop, 1995.
22. Martell RW, Arendse A, Jacobs M, Taljaard D, Du Toit ED. A new HLA-DR2-related specificity (DR2LUM) in South African populations detected using polymerase chain reaction and sequence-specific oligonucleotide typing. Tissue Antigens 1991: 37: 232-4.
23. Schreuder GMT, Verduyn W, Du Toit ED, Oudshoorn M, Giphart MJ. Absence of HLA-DR2 DRB1 and DRB5 genes in DR1+2s and DR2LUM specificities, respectively. In: Tsuji K, Aizawa M, Sasazuki T, ed. HLA 1991 vol. 2. Oxford: Oxford University Press, 1992: 259-62.
24. Naruse TK, Ando R, Nose Y et al. HLA-DRB4 genotyping by PCR-RFLP: diversity in the associations between HLA-DRB4 and DRB1 alleles. Tissue Antigens 1997: 49: 152-159.
25. Ting A, Morris PJ. Matching for B-cell antigens of the HLA-DR series in cadaver renal transplantation. Lancet 1978: i: 575-7.