p27(kip1) expression distinguishes papillary hyperplasia in Graves' disease from papillary thyroid carcinoma

Modern Pathology

Volumn 13, Issue 9, 2000, Pages 1014-1019

  Erickson, Lori A ^a   Yousef, Omar M ^a   Jin, Long ^a   Lohse, Christine M ^a   Pankratz, V Shane ^a   Lloyd, Ricardo V ^a  

^a MAYO CLINIC   (United States)

Author keywords

Graves' disease; Ki 67; p27; Papillary carcinoma; Topoisomerase II

Indexed keywords

KI 67 ANTIGEN; PROTEIN P27; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DNA BINDING PROTEIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE II ALPHA; ISOENZYME; MICROTUBULE ASSOCIATED PROTEIN; TUMOR ANTIGEN; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CANCER DIAGNOSIS; CELL CYCLE; DIFFERENTIAL DIAGNOSIS; GRAVES DISEASE; HUMAN; HUMAN TISSUE; HYPERTHYROIDISM; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYROID CARCINOMA; THYROID DISEASE; THYROID PAPILLARY CARCINOMA; ADULT; CELL NUCLEUS; DRUG ANTAGONISM; ENZYME IMMUNOASSAY; FEMALE; HYPERPLASIA; MALE; METABOLISM; MIDDLE AGED; PAPILLARY CARCINOMA; PATHOLOGY; THYROID TUMOR;

ADULT; ANTIGENS, NEOPLASM; CARCINOMA, PAPILLARY; CELL CYCLE PROTEINS; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; DIAGNOSIS, DIFFERENTIAL; DNA TOPOISOMERASES, TYPE II; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; FEMALE; GRAVES DISEASE; HUMANS; HYPERPLASIA; IMMUNOENZYME TECHNIQUES; ISOENZYMES; KI-67 ANTIGEN; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; THYROID NEOPLASMS; TUMOR SUPPRESSOR PROTEINS;

EID: 0033626268     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1038/modpathol.3880182     Document Type: Article

References (35)

1. Tumors of the thyroid gland
2. Aberrant p27kip1 expression in endocrine and other tumors
3. Expression of p27kip1 and Ki-67 in benign and malignant thyroid tumors
4. Immunohistochemical analysis of p27/kip1 expression in thyroid carcinoma
5. P27kip1: A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers
6. TGF-B, TGF-B receptors. Ki-67 and p27kip1 expression in papillary thyroid carcinomas
7. Inhibitors of mammalian G1 cyclin-dependent kinases
8. G1 control in mammalian cells
9. Parathyroid hyperplasia, adenomas, and carcinomas: Differential expression of p27Kip1 protein
10. Downregulation of p27KIP1 and KI67/MIB-1 labeling index support the classification of thyroid carcinoma into prognostically relevant categories
11. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67
12. Differential expression of DNA topoisomerase I and II during the eukaryotic cell cycle
13. Human DNA topoisomerase II-alpha: A novel new marker of cell proliferation in invasive breast cancer
14. Immuno-histochemical staining for DNA topoisomerase II in non-Hodgkin's lymphomas
15. DNA topoisomerase II mutant of Saccharomyces cerevisiae: Topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication
16. DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosome breakage
17. Immunohistochemical analysis of thyroid carcinomas utilizing antibodies to p53 and Ki-67
18. Proliferation markers and their uses in the study of endocrine tumors
19. Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors: A phenotype/genotype correlation
20. Transforming growth factor-B, transforming growth factor-B receptor II, and p27kip1 expression in nontumorous and neoplastic human pituitaries
21. Expression of p27kip1 and Ki-67 in pituitary adenomas: An investigation of marker of adenoma invasiveness
22. Expression of cell cycle inhibitor p27 and Ki-67 in human adrenocortical neoplasms
23. The role of cell cycle regulatory proteins, cyclin D1, cyclin E, and p27 in thyroid carcinogenesis
24. Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells
25. Immunohistochemical staining of DNA topoisomerase II alpha in human gliomas
26. Immunohistochemical detection of DNA to-poisomerase type II alpha and Ki-67 in adenoid cystic carcinoma and pleomorphic adenoma of the salivary gland
27. Topoisomerase II alpha expression in esophageal squamous cell carcinoma
28. Topoisomerase II alpha expression in normal, inflammatory, and neoplastic conditions of the gastric and colonic mucosa
29. DNA topoisomerase II alpha and Ki-67 in human adrenocortical neoplasms: A possible marker of differentiation between adenomas and carcinomas
30. Immunohistochemical analysis of DNA topoisomerase II in thyroid neoplasia
31. Incidence of thyroid carcinoma in Graves' disease
32. Thyroid carcinoma in Graves' disease
33. The spectrum of thyroid disease in a community: The Whickham survey
34. Increased aggressiveness of thyroid cancer in patients with Graves' disease
35. The role of thyroid-stimulating antibodies of Graves' disease in differentiated thyroid cancer