Evaluation of 225Ac for vascular targeted radioimmunotherapy of lung tumors

Cancer Biotherapy and Radiopharmaceuticals

Volumn 15, Issue 3, 2000, Pages 235-244

  Kennel, Stephen J ^a   Chappell, Lara L ^b   Dadachova, Kate ^b   Brechbiel, Martin W ^b   Lankford, Trish K ^a   Davis, Ila A ^a   Stabin, Michael ^c   Mirzadeh, Saed ^a  

^a OAK RIDGE NATIONAL LABORATORY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

Ac 225; HEHA; Radiotoxicity; Vascular targeting

Indexed keywords

ACTINIUM;

ALPHA RADIATION; ANIMAL EXPERIMENT; ARTICLE; AXILLARY LYMPH NODE; CANCER IMMUNOTHERAPY; CANCER RADIOTHERAPY; FEMALE; LUNG TUMOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOTHERAPY; ANIMAL; BAGG ALBINO MOUSE; RADIATION DOSE; TISSUE DISTRIBUTION; VASCULARIZATION;

ACTINIUM; ALPHA PARTICLES; ANIMALS; FEMALE; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; RADIOIMMUNOTHERAPY; RADIOTHERAPY DOSAGE; TISSUE DISTRIBUTION;

EID: 0033624570     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/108497800414329     Document Type: Article

References (29)

1. McDevitt MR, Sgouros G, Finn RD, Humm JL, Jurcic JG, Larson SM, Scheinberg, DA. Radioimmunotherapy with alpha-emitting nuclides. Eur J Nucl Med 1998; 25: 1341.
2. th.
3. McLendon RE, Archer GE, Larsen RH, Akabani G, Bigner DD, Zalutsky MR. Radiotoxicity of systematically administered 211 At-labeled human/mouse chimeric monoclonal antibody: a long term survival study with histologic analysis. Int J Radiat Oncol Biol Phys 1999; 45:491.
4. Zalutsky MR, Akabani G, Cokgor I, Friedman HS, Coleman RE, Friedman AH, McLendon RE, Reist CJ, Pegram CN, Zhau X-G, Bugner, DD. Phase I Trial of astatine-211 labeled human/mouse chimeric antitenascin antibody administerd into malignant brain tumor resection cavities. Neuro-Oncology 1999; 1: S65.
5. Behr TM, Goldenberg DM, Becker WS. Radioimmunotherapy of solid tumors: a review "of mice and men." Hybridoma 1999; 16: 101.
6. 225Ac as a source of α-particles in radioimmunotherapy. Nucl Med Commun 1993; 14: 121.
7. Chen X, Ji M, Fisher D, Wai, CM. Carboxylate-derived calixerines with high selectivity for actinium-225. Chem Commun 1998; 377.
8. 225Actinium chelates: Tissue distribution and radiotoxicity. Nucl Med Biol 1999; 26: 581
9. Deal KA, Davis IA, Mirzadeh S, Kennel SJ, Brechbiel MW. The improved stability of Actinium-225 macrocyclic complexes. J Med Chem 1999; 42: 2988.
10. 225Ac for applications in radioimmunotherapy. Bioconjugate Chem 2000; in press.
11. Ford VA, Stringer C, Kennel SJ. Quantitation of thrombomodulin in BALB/c organs suggests preferential expression in lung microvessels. J Biol Chem 1993; 267: 5446.
12. 213Bi. Radiochim Acta 1997; 79:87.
13. Kennel SJ, Lee R, Boltman S, Kabalka G. Rat monoclonal antibody distribution in mice. An epitope inside the vascular space mediates very efficient localization. Nucl Med Biol 1990; 17: 193.
14. Hughes BJ, Kennel S, Lee R, Huang L. Monoclonal antibody targeting of liposomes to mouse lung in vivo. Cancer Res 1989; 49: 6214.
15. 213Bi-An alphaparticle emitter. Nucl Med Biol 1998; 25:241.
16. 213Bi. Brit J Cancer 1999; 80:175.
17. 213Bi. Nucl Med Biol 1999; 26:149.
18. Rockwell SC, Kallman RF, Fajardo LF. Characteristics of a serially transplanted mouse mammary tumor and its tissue-culture-adapted derivative. J Natl Cancer Inst 1972; 49: 735.
19. 213Bi. Radichem Acta 1997; 79: 145.
20. Kennel SJ, Lankford T, Hughes B, Hotchkiss JA. Quantitation of a specific murine lung endothelial cell protein, P112, with a double monoclonal antibody assay. Lab Invest 1983; 59: 692.
21. Mirzadeh S, Brechbiel MW, Gansow OA. Radiometal labeling of immunoproteins: covalent linkage of 2-(4-isothiocyanatobenzyl)-DTPA to immunoglobulin. Bioconjugate Chem 1990; 1: 59
22. Dadachova E, Chappell L, Brechbiel MW. Spectrophotometric method for determination of bifunctional macrocyclic ligand-protein conjugates. Nucl Med Biol 1999; 26: 977.
23. 212Pb(DOTA)2~ complex. Radiochemica Acta 1993; 60:1
24. Beyer GJ, Offord RE, Kunzi G, Jones RML, Ravin U, Aleksandrova Y, Werlen RC, Macke H, Lindros M, Jahn S, Tengblad D. Biokinetics of monoclonal antibodies labelled with radio-lanthanides and 225-Ac in xenografted nude mice. J Label Cmpds Radiopharm 1995; 37: 529.
25. Brechbiel MW, Gansow OA. Synthesis of C-functionised trans cyclohexyldiethyleneaminopenta-acetic acids for labeling of monoclonal antibodies with the bismuth-212 α particle emitter. J Chem Soc Perkin Tran I. 1992; 1173.
26. Kumar K, Magerstadt M, Gansow OA. Lead (III) and Bi (III) complexes of the polyazacycloalkane-N-acetic Acid NOTA, DOTA and TETA. J Chem Soc Chem Commun 1989; 145.
27. Mears CF. Chelating agents for the binding of metal ions to antibodies. J Nucl Med Biol 1986; 13: 311.
28. Delgado R, de Silva JJRF. Metal complexes of cyclic tetra-azatetra-acetic acids. Talanta 1982; 29: 815.
29. Pauling L. Nature of Chemical Bond, 3rd ed. Ithaca, NY, Cornell University, 1960