Radioimmunotherapy of solid tumors: A review 'Of mice and men'

Hybridoma

Volumn 16, Issue 1, 1997, Pages 101-107

  Behr, Thomas M ^a,b   Goldenberg, David M ^b   Becker, Wolfgang S ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY I 131; FLUOROURACIL; FOLINIC ACID; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; YTTRIUM 90;

ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; BONE MARROW TOXICITY; CLINICAL TRIAL; CONFERENCE PAPER; DRUG HALF LIFE; DRUG UPTAKE; HUMAN; LUNG TUMOR; NONHUMAN; NUDE MOUSE; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RADIATION DOSE; RADIATION RESPONSE; RADIOIMMUNOTHERAPY; SOLID TUMOR; TUMOR MODEL;

EID: 0030892553     PISSN: 0272457X     EISSN: None     Source Type: Journal    
DOI: 10.1089/hyb.1997.16.101     Document Type: Conference Paper

References (18)

1. Goldenberg DM (ed.). Cancer Therapy with Radiolabeled Antibodies. CRC Press, Boca Raton, Ann Arbor, London, Tokyo, 1995.
2. Köhler G, and Milstein C: Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975:256:495-499.
3. Behr TM, Sharkey RM, Juweid ME, Blumenthal RD, Dunn RM, Bair HJ, Griffiths GL, Wolf FG, Becker WS, and Goldenberg DM: Reduction of the renal uptake of radiolabeled monoclonal antibody fragments by cationic amino acids and their derivatives. Cancer Res 1995:55:3825-3834.
4. Behr TM, Becker WS, Sharkey RM, Juweid ME, Dunn RM, Bair HJ, Wolf FG, and Goldenberg DM: Reduction of the renal uptake of monoclonal antibody fragments by amino acid infusion. J Nucl Med 1996;37:829-833.
5. Behr TM, and Goldenberg DM: Improved prospects for cancer therapy with radiolabeled antibody fragments and peptides? J Nucl Med 1996;37:834-836.
6. Behr TM, Sharkey RM, Blumenthal RD, Sgouros G, Dunn RM, Alisauskus R, Griffiths G, and Goldenberg DM: Overcoming nephrotoxicity in therapy with radiometal-conjugated antibody fragments and peptides: Improvement of their therapeutic efficacy? J Nucl Med 1996;37:96P.
7. Press OW, Eary JF, Appelbaum FR, Martin PJ, Badger CC, Nelp WB, Glenn S, Butchko G, Fisher D, Porter B, Matthews DC, Fisher LD, and Bernstein ID: Radiolabeled-antibody therapy of B-cell lymphoma with autologous bone marrow support. N Engl J Med 1993:329:1219-1224.
8. 131I-labeled anti-CEA murine IgG monoclonal antibody. J Nucl Med 1997;38 (in press).
9. Schmid J, Möller P, Moldenhauer G, Dörken B, Bihl H, and Matzku S: Monoclonal antibody uptake in B-cell lymphomas: experimental studies in nude mouse xenografts. Cancer Immunol Immunother 1993:36:274-280.
10. Galenos: Über die krankhaften Geschwülste ("περι των παρα φυσιν ογκων"). Translated by P. Richter. In: Klassiker der Medizin. Sudhoff K (Ed.). Verlag von Johann Ambrosius Barth, Leipzig, 1913.
11. 131I-labeled monoclonal antibodies. Cancer Res 1992:52:6036-6044.
12. Blumenthal RD, Sharkey RM, Natale AM, Kashi R, Wong G, and Goldenberg DM: Comparison of equitoxic radioimmunotherapy and chemotherapy in the treatment of human colonic cancer xenografts. Cancer Res 1994:54:142-151.
13. Jain RK. Determination of tumor blood flow: A review. Cancer Res 1988:48:2641-2658.
14. Juweid M, Neumann R, Paik C, Perez-Becete MJ, Sato J, van Osdol W, and Weinstein JN: Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier. Cancer Res 1992:52:5144-5153.
15. 99mTc-labeled anti-CEA monoclonal antibodies for immunoscintigraphy in colorectal cancer. J Nucl Med 1995:36: 430-441.
16. 99mTc: the role of metabolism and kinetics. Cancer Res 1995;55:5777s-5785s.
17. 90YDosimetry in the nude mouse: evaluation of three dosimetry models in relation to the observed biological effects in the radioimmunotherapy (RAIT) of human colon cancer xenografts. Proceedings of the 6th International Radiopharmaceutical Dosimetry Symposium in Gatlinburg, TN, 1997 (in press).
18. Behr TM, Sharkey RM, Juweid ME, Aninipot R, Mattes MJ, Stein R, Griffiths GL, and Goldenberg DM: Residualizing (indium, yttrium) versus released (iodine) isotopes in radioimmunodetection and therapy with internalizing antibodies. J Nucl Med 1995;36:20P (abstract 71).