Induction of female Sex-lethal RNA splicing in male germ cells: Implications for Drosophila germline sex determination

Development

Volumn 124, Issue 24, 1997, Pages 5033-5048

  Hager, Jeffrey H ^a   Cline, Thomas W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Drosophila melanogaster; Germ cell; RNA splicing; Sex determination; Sex lethal; Splicing necessary factor; Triploid intersexes

Indexed keywords

MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOREGULATION; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; EMBRYO; FEMALE; FEMINIZATION; GENE; GENE DOSAGE; GERM CELL; GERM LINE; MALE; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; RNA SPLICING; SEX DETERMINATION; SPERMATOGENESIS; TRIPLOIDY; X CHROMOSOME;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CROSSES, GENETIC; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; GENE DOSAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GERM CELLS; INSECT PROTEINS; MALE; MUTATION; PHENOTYPE; POLYPLOIDY; RIBONUCLEOPROTEIN, U1 SMALL NUCLEAR; RNA SPLICING; RNA-BINDING PROTEINS; SEX DETERMINATION (GENETICS); TRANSCRIPTION FACTORS; X CHROMOSOME;

EID: 0031468235     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Albrecht, E. B. and Salz, H. K. (1993). The Drosophila sex determination gene snf is utilised for the establishment of the female-specific splicing pattern of Sex-lethal. Genetics 134, 801-7.
2. Bachiller, D. B. and Sánchez, L. (1986). Mutations affecting dosage compensation in Drosophila melanogaster: effects in the germline. Dev. Biol. 118, 379-384.
3. Bae, E., Cook, K. R., Geyer, P. K. and Nagoshi, R. N. (1994). Molecular characterization of ovarian tumors in Drosophila. Mech. Dev. 47, 151-164.
4. Bashaw, G. J. and Baker, B. S. (1997). The regulation of the Drosophila msl-2 gene reveals a function for Sex-lethal in translational control. Cell 89, 789-798.
5. Bell, L. R., Horabin, J. I., Schedl, P. and Cline, T. W. (1991). Positive autoregulation of Sex-lethal by alternative splicing maintains the female determined state in Drosophila. Cell 65, 229-239.
6. Bell, L. R., Maine, E. M., Schedl, P. and Cline, T. W. (1988). Sex-lethal, a Drosophila sex determination switch gene. exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins. Cell 55, 1037-1046.
7. Bernstein, M., Lersch, R. A., Subrahmanyan, L. and Cline, T. W. (1995). Transposon insertions causing constitutive Sex-lethal activity in Drosophila melanogaster affect Sxl sex-specific transcript splicing. Genetics 139, 631.
8. Bopp, D., Bell, L. R., Cline, T. W. and Schedl, P. (1991). Developmental distribution of female-specific Sex-lethal proteins in Drosophila melanogaster. Genes Dev. 5, 403-415.
9. Bopp, D., Calhoun, G., Horabin, J. I., Samuels, M. and Schedl, P. (1996). Sex-specific control of Sex-lethal is a conserved mechanism for sex determination in the genus Drosophila. Development 122, 971-82.
10. Bopp, D., Horabin, J. I., Lersch, R. A., Cline, T. W. and Schedl, P. (1993). Expression of the Sex-lethal gene is controlled at multiple levels during Drosophila oogenesis. Development 118, 797-812.
11. Cline, T. W. (1983a). Functioning of the genes daughterless and Sex-lethal in Drosophila germ cells. Genetics 104, s16-s17 (Abstr.).
12. Cline, T. W. (1983b). The interaction between daughterless and Sex-lethal in triploids: a lethal sex-transforming maternal effect linking sex determination and dosage compensation in Drosophila melanogaster. Dev. Biol. 95, 260-74.
13. Cline, T. W. (1984). Autoregulatory functioning of a Drosophila gene product that establishes and maintains the sexually determined state. Genetics 107, 231-277.
14. Cline, T. W. (1988). Evidence that sisterless-a and sisterless-b are two of several discrete 'numerator elements' of the X/A sex determination signal in Drosophila that switch Sxl between two alternative stable expression states. Genetics 119, 829-862.
15. Cline, T. W. and Meyer, B. J. (1996). Vive la difference: males vs. females in flies vs. worms. Anna. Rev. Genet. 30, 637-702.
16. Comer, A. R., Searles, L. L. and Kalfayan, L. J. (1992). Identification of a genomic DNA fragment containing the Drosophila melanogaster ovarian tumor gene (otu) and localization of regions governing its expression. Gene 118, 171-179.
17. Cronmiller, C. and Cline, T. W. (1987). The Drosophila sex determination gene daughterless has different functions in the germ line versus the soma. Cell 48, 479-87.
18. Flickinger, T. W. and Salz, H. K. (1994). The Drosophila sex determination gene snf encodes a nuclear protein with sequence and functional similarity to the mammalian U1A snRNP protein. Genes Dev. 8, 914-925.
19. Fuller, M. T. (1993). Spermatogenesis. In The development of Drosophila melanogaster. (ed. M. Bate and A. Martinez-Arias). Vol. 1, pp. 71-147. Plainview, New York: Cold Spring Harbor Laboratory Press.
20. Gans, M., Audit, C. and Masson, M. (1975). Isolation and characterization of sex-linked female-sterile mutations in Drosophila melanogaster. Genetics 81, 683-704.
21. Geyer, P. K., Pattern, J. S., Rodesch, C. and Nagoshi, R. N. (1993). Genetic and molecular characterization of P element-induced mutations reveals that the Drosophila ovarian tumor gene has maternal activity and a variable null phenotype. Genetics 133, 265-278.
22. Gollin, S. M. and King, R. C. (1981). Studies of fs(1)1621, a mutation producing ovarian tumors in Drosophila melanogaster. Dev. Genet. 2, 203-218.
23. Gönczy, P., Viswanathan, S. and DiNardo, S. (1992). Probing spermatogenesis in Drosophila with P-element enhancer detectors. Development 114, 89-98.
24. Gunderson, S. I., Beyer, K., Martin, G., Keller, W., Boelens, W. C. and Mattaj, I. W. (1994). The human U1A snRNP protein regulates polyadenylation via a direct interaction with poly(A) polymerase. Cell 76, 531-541.
25. Horabin, J. I., Bopp, D., Waterbury, J. and Schedl, P. (1995). Selection and maintenance of sexual identity in the Drosophila germline. Genetics 141, 1521-1535.
26. Kelley, R. L., Wang, J., Bell, L. and Kuroda, M. I. (1997). Sex-lethal controls dosage compensation in Drosophila by a non-splicing mechanism. Nature 387, 195-199.
27. Keyes, L. N., Cline, T. W. and Schedl, P. (1992). The primary sex determination signal of Drosophila acts at the level of transcription. Cell 68, 933-943.
28. Lersch, R., Hager, J. and Cline, T. W. (1994). Mutant lesions in the sex-determination gene, Sex-lethal, differentially affecting somatic and germline functions. In 35th Annual Drosophila Conference (ed. V. Finnerty). Vol. 35, pp. 246. Chicago. Illinois: Genetics Society of America.
29. Lindsley, D. L. and Zimm, G. G. (1992). The Genome of Drosophila melanogaster. San Diego, CA: Academic Press.
30. Mahowald, A. P. and Wei, G. (1994). Sex determination of germ cells in Drosophila. Ciba Found Symp 182, 193-202: discussion 202-9.
31. Maine, E. M., Salz, H. K., Cline, T. W. and Schedl, P. (1985). The Sex-lethal gene of Drosophila: DNA alterations associated with sex-specific lethal mutations. Cell 43, 521-529.
32. Marsh, J. L. and Wieschaus, E. (1978). Is sex determination in germ line and soma controlled by separate genetic mechanisms? Nature 272, 249-251.
33. McKeown, M., Belote, J. M. and Boggs, R. T. (1988). Ectopic expression of the female transformer gene product leads to female differentiation of chromosomally male Drosophila. Cell 53, 887-95.
34. Nagoshi, R. N., Patton, J. S., Bae, E. and Geyer, P. (1995). The somatic sex determines the requirement for ovarian tumor gene activity in the proliferation of the Drosophila germline. Development 121, 579-587.
35. Nicklas, J. A. and Cline, T. W. (1983). Vital genes that flank Sex-lethal, an X-linked sex-determining gene of Drosophila melanogaster. Genetics 103, 617-631.
36. Nöthiger, R., Jonglez, M., Leuthold, M., Gerschwiler, P. M. and Weber, T. (1989). Sex determination in the germline of Drosophila depends on genetic-signals and inductive somatic factors. Development 107, 505-518.
37. Oliver, B., Kim, Y.-J. and Baker, B. S. (1993). Sex-lethal, master and slave: a hierarchy of germ-line sex determination in Drosophila. Development 119, 897-908.
38. Oliver, B., Perrimon, N. and Mahowald, A. (1988). Genetic evidence that the sans fille locus is involved in Drosophila sex determination. Genetics 120, 159-171.
39. Oliver, B., Perrimon, N. and Mahowald, A. P. (1987). The ovo locus is required for sex-specific germ line maintenance in Drosophila. Genes Dev. 1, 913-923.
40. + in germ-line sex determination depends on X-chromosome number. Development 120, 3185-95.
41. Parkhurst, S. M., Lipshitz, H. D. and Ish-Horowicz, D. (1993). achaetescute feminizing activities and Drosophila sex determination. Development 117, 737-749.
42. Pauli, D., Oliver, B. and Mahowald, A. P. (1993). The role of the ovarian tumor locus in Drosophila melanogaster germ line sex determination. Development 119, 123-134.
43. Pirrotta, V. (1988). Vectors for P-mediated transformation in Drosophila. In Vectors, a survey of molecular cloning vectors and their uses. (ed. R. L. Rodriguez and D. T. Denhardt). Boston, MA: Butterworths.
44. Poirié, M., Niederer, E. and Steinmann-Zwicky, M. (1995). A sex-specific number of germ cells in embryonic gonads of Drosophila. Development 121, 1867-73.
45. Rodesch, C., Geyer, P. K., Patton, J. S., Bae, E. and Nagoshi, R. N. (1995). Developmental analysis of the ovarian tumor gene during Drosophila oogenesis. Genetics 141, 191-202.
46. Salz, H. K. (1992). The genetic analysis of snf: a Drosophila sex determination gene required for activation of Sex-lethal in both the germline and the soma. Genetics 130, 547-554.
47. Salz, H. K. and Hickinger, T. W. (1996). Both loss-of-function and gain-of-function mutations in snf define a role for snRNP proteins in regulating Sex-lethal pre-mRNA splicing in Drosophila development. Genetics 144, 95-108.
48. Salz, H. K., Maine, E. M., Keyes, L. N., Samuels, M. E., Cline, T. W. and Schedl, P. (1989). The Drosophila female-specific sex-determination gene. Sex-lethal, has stage-, tissue-, and sex-specific RNAs suggesting multiple modes of regulation. Genes Dev. 3, 708-19.
49. Schüpbach, T. (1982). Autosomal mutations that interfere with sex determination in somatic cells of Drosophila have no direct influence on the germ line. Dev. Biol. 89, 117-127.
50. Schüpbach, T. (1985). Normal female germ cell differentiation requires the female X chromosome to autosome ratio and expression of Sex-lethal in Drosophila melanogaster. Genetics 109, 529-548.
51. Spradling, A. C. (1986). P-element-mediated transformation. In Drosophila, a Practical Approach. (ed. D. B. Roberts). Oxford, UK: IRL Press.
52. Spradling, A. C. (1993). Developmental genetics of oogenesis. In The Development of Drosophila melanogaster. (ed. M. Bate and A. Martinez-Arias). Vol. 1, pp. 1-70. Plainview, New York: Cold Spring Harbor Laboratory Press.
53. Staab, S., Heller, A. and Steinmann-Zwicky, M. (1996). Somatic sex-determining signals act on XX germ cells in Drosophila embryos. Development 122, 4065-4071.
54. Staab, S. and Steinmann-Zwicky, M. (1995). Female germ cells of Drosophila require zygotic ovo and otu products for survival in larvae and pupae respectively. Mech. Dev. 54, 205-210.
55. Steinmann-Zwicky, M. (1988). Sex determination in Drosophila: the X-chromosomal gene liz is required for Sxl activity. EMBO J. 7, 3889-3898.
56. Steinmann-Zwicky, M. (1993). Sex determination in Drosophila: sis-b. a major numerator element of the X:A ratio in the soma. does not contribute to the X:A ratio in the germ line Development 117, 763-7.
57. Steinmann-Zwicky, M. (1994a). Sex determination of the Drosophila germ line: tra and dsx control somatic inductive signals. Development 120, 707-16.
58. Steinmann-Zwicky, M. (1994b). Sxl in the germline of Drosophila: a target for somatic late induction. Dev. Genet. 15, 265-74.
59. Steinmann-Zwicky, M., Schmid, H. and Nöthiger, R. (1989). Cell autonomous and inductive signals can determine the sex of the germline of Drosophila by regulating the gene Sxl. Cell 57, 157-166.
60. Wei, G., Oliver, B., Pauli, D. and Mahowald, A. P. (1994). Evidence for sex transformation of germline cells in ovarian tumor mutants of Drosophila. Dev. Biol. 161, 318-320.
61. Zhou, S., Yang, Y., Scott, M. J., Pannuti, A., Fehr, K. C., Eisen, A., Koonin, E. V., Fouts, D. L., Wrightsman, R., Manning, J. E. and Lucchesi, J. C. (1995). Male-specific lethal-2, a dosage compensation gene of Drosophila undergoes sex-specific regulation and encodes a protein with a RING finger and a metallolhionein-like cysteine cluster. EMBO J. 14, 2884-2895.