Analysis of the doublesex female protein in Drosophila melanogaster: Role in sexual differentiation and behavior and dependence on intersex

Genetics

Volumn 152, Issue 4, 1999, Pages 1653-1667

  Waterbury, Julie A ^a   Jackson, Larry L ^b   Schedl, Paul ^a  

^a PRINCETON UNIVERSITY   (United States)

^b MONTANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; DNA; PHEROMONE; PROTEIN DSX; RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; FEMALE; GENE EXPRESSION; GENE MUTATION; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN DNA BINDING; RNA SPLICING; SEX DIFFERENTIATION; SEXUAL BEHAVIOR;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EGG PROTEINS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HERMAPHRODITISM; INSECT PROTEINS; MALE; PHEROMONES; SEX CHARACTERISTICS; SEX DIFFERENTIATION; SEXUAL BEHAVIOR, ANIMAL; TRANSGENES; VITELLOGENINS;

ANIMALIA; DROSOPHILA MELANOGASTER; HEXAPODA; INVERTEBRATA; MELANOGASTER;

EID: 0345363237     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. AN, W., and P. C. WENSINK, 1995a Three protein binding sites form an enhancer that regulates sex- and fat body-specific transcription of Drosophila yolk protein genes. EMBO J. 14: 1221-1230.
2. AN, W., and P. C. WENSINK, 1995b Integrating sex- and tissue-specific regulation within a single Drosophila enhancer. Genes Dev. 9: 256-266.
3. AN, W., S. CHO, H. ISHII and P. C. WENSINK, 1996 Sex-specific and non-sex-specific oligomerization domains in both of the doublesex transcription factors from Drosophila melanogaster. Mol. Cell. Biol. 16: 3106-3111.
4. ANTONY, C., and J. M. JALLON, 1982 The chemical basis for sex recognition in Drosophila melanogaster. J. Insect Physiol. 28: 873-880.
5. ANTONY, C., T. L. DAVIS, D. A. CARLSON, J. M. PECHINE and J. M. JALLON, 1985 Compared behavioral responses of male Drosophila melanogaster (Canton S) to natural and synthetic aphrodisiacs. J. Chem. Ecol. 11: 1617-1629.
6. BAKEK, B. S., 1989 Sex in flies: the splice of life. Nature 340:521-524.
7. BAKER, B. S., and K. A. RIDGE, 1980 Sex and the single cell. I. On the action of major loci affecting sex determination in Drosophila melanogaster. Genetics 94: 383-423.
8. BAKER, B. S., and M. F. WOLFNER, 1988 A molecular analysis of doublesex, a bifunctional gene that controls both male and female sexual differentiation in Drosophila melanogaster. Genes Dev. 2: 477-489.
9. BELLEN, H. J., C. J. O'KANE, C. WILSON, U. GROSSNIKLAUS, R. K. PEARSON et al., 1989 P-element-mediated enhancer detection: a versatile method to study development in Drosophila. Genes Dev. 3: 1288-1300.
10. BOPP, D., J. I. HORABIN, R. A. LERSCH, T. W. CLINE and P. SCHEDL, 1993 Expression of the Sex-lethal gene is controlled at multiple levels during Drosophila oogenesis. Development 118: 797-812.
11. BOWNES, M., and R. NÖTHIGER, 1981 Sex determining genes and vitellogenin synthesis in Drosophila melanogaster. Mol. Gen. Genet. 182: 222-228.
12. BURTIS, K. C., and B. S. BAKER, 1989 Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides. Cell 56: 997-1010.
13. BURTIS, K. C., K. T. COSCHIGANO, B. S. BAKER and P. C. WENSINK, 1991 The doublesex proteins of Drosophila melanogaster bind directly to a sex-specific yolk protein gene enhancer. EMBO J. 10: 2577-2582.
14. BUTTERWORTH, F. M., 1969 Lipids of Drosophila: a newly detected lipid in the male. Science 163: 1356-1357.
15. CARLSON, D. A., C. S. ROAN, R. A. YOST and J. HECTOR, 1989 Dimethyl disulfide derivatives of long chain alkenes, alkadienes, and alkatrienes for gas chromatography/mass spectrometry. Anal. Chem. 61: 1564-1571.
16. CHASE, B. A., and B. S. BAKER, 1995 A genetic analysis of intersex, a gene regulating sexual differentiation in Drosophila melanogaster females. Genetics 139: 1649-1661.
17. CHO, S., and P. C. WENSINK, 1997 DNA binding by the male and female doublesex proteins of Drosophila melanogaster. J. Biol. Chem. 272: 3185-3189.
18. CLINE, T. W., 1978 Two closely linked mutations in Drosophila melanogaster that are lethal to opposite sexes and interact with daughter-less. Genetics 90: 683-698.
19. CLINE, T. W., 1984 Autoregulation functioning of a Drosophila gene product that establishes and maintains the sexually determined state. Genetics 107: 231-277.
20. CLINE, T. W., 1988 Evidence that sisterless-a and sisterless-b are two of several discrete "numerator elements" of the X/A sex determination signal in Drosophila that switch Sxl between two alternative stable expression states. Genetics 119: 829-862.
21. CLINE, T. W., and B. J. MEYER, 1996 Vive la difference: males vs females in flies vs worms. Annu. Rev. Genet. 30: 637-702.
22. COBB, M., and J. F. FERVEUR, 1996a Female mate discrimination or male responses to female stimulation? Evolution 50: 1719-1720.
23. COBB, M., and J. F. FERVEUR, 1996b Evolution and genetic control of mate recognition and stimulation in Drosophila. Behav. Processes 35: 35-54.
24. COBB, M., and J. M. JALLON, 1990 Pheromones, mate recognition and courtship stimulation in Drosophila melanogaster species subgroup. Animal Behav. 39: 1058-1067.
25. COSCHIGANO, K. T., and P. C. WENSINK, 1993 Sex-specific transcriptional regulation by the male and female doublesex proteins of Drosophila. Genes Dev. 7: 42-54.
26. ERDMAN, S. E., and K. C. BURTIS, 1993 The Drosophila doublesex proteins share a novel zinc finger related DNA binding domain. EMBO J. 12: 527-535.
27. EROMAN, S. E., H. J. CHEN and K. C. BURTIS, 1996 Functional and genetic characterization of the oligomerization and DNA binding properties of the Drosophila doublesex proteins. Genetics 144: 1639-1652.
28. FERVEUR, J. F., 1997 The pheromonal role of cuticular hydrocarbons in Drosophila melanogaster. Bioessays 19: 353-358.
29. FERVEUR, J. F., and G. SUREAU, 1996 Simultaneous influence on male courtship of stimulatory and inhibitory pheromones produced by live sex-mosaic Drosophila melanogaster. Proc. R. Soc. Lond. B Biol. Sci. 263: 967-973.
30. FERVEUR, J. F., F. SAVARIT, C. J. O'KANE, G. SUREAU, R. J. GREENSPAN et al., 1997 Genetic feminization of pheromones and its behavioral consequences in Drosophila males. Science 276: 1555-1558.
31. FINLEY, K. D., B. J. TAYLOR, M. MILSTEIN and M. MCKEOWN, 1997 dissatisfaction, a gene involved in sex-specific behavior and neural development of Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 94: 913-918.
32. FINLEY, K. D., P. T. EDEEN, M. FOSS, E. GROSS, N. GHBEISH et al., 1998 dissatisfaction encodes a tailless-like nuclear receptor expressed in a subset of CNS neurons controlling Drosophila sexual behavior. Neuron 21: 1363-1374.
33. HALL, J. C., 1994 The mating of a fly. Science 264: 1702-1714.
34. HEDLEY, M. L., and T. MANIATIS, 1991 Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro. Cell 65: 579-586.
35. HING, A. L., and J. R. CARLSON, 1996 Male-male courtship behavior induced by ectopic expression of the Drosophila white gene: role of sensory function and age. J. Neurobiol. 30: 454-464.
36. HORABIN, J. I., and P. SCHEDL, 1993 Regulated splicing of the Drosophila sex-lethal male exon involves a blockage mechanism. Mol. Cell. Biol. 13: 1408-1414.
37. HUNG, M. C., T. BARNETT, C. WOOLFORD and P. C. WENSINK, 1982 Transcript maps of Drosophila yolk protein genes. J. Mol. Biol. 154: 581-602.
38. ITO, H., K. FUJITANI, K. USUI, K. SHIMIZU-NISHIKAWA, S. TANAKA et al., 1996 Sexual orientation in Drosophila is altered by the satori mutation in the sex-determination gene fruitless that encodes a zinc finger protein with a BTB domain. Proc. Natl. Acad. Sci. USA 93: 9687-9692.
39. JALLON, J. M., 1984 A few chemical words exchanged by Drosophila during courtship and mating. Behav. Genet. 14: 441-478.
40. JALLON, J. M., G. LAUGE, L. ORSSAUD and C. ANTONY, 1988 Female pheromones in Drosophila melanogaster are controlled by the doublesex locus. Genet. Res. 51: 17-22.
41. JURSNICH, V. A., and K. C. BURTIS, 1993 A positive role in differentiation for the male doublesex protein of Drosophila. Dev. Biol. 155: 235-249.
42. LI, H., and B. S. BAKER, 1998 hermaphrodite and doublesex function both dependency and independently to control various aspects of sexual differentiation in Drosophila. Development 125: 2641-2651.
43. MCROBERT, S. P., and L. TOMPKINS, 1985 The effect of transformer, doublesex and intersex mutations on the sexual behavior of Drosophila melanogaster. Genetics 111: 89-96.
44. MEISE, M., D. KILFIKER-KLEINER, A. D. BENDORFER, C. BRUNNER, R. NOTHIGER et al., 1998 Sex-lethal, the master sex-determining gene in Drosophila, is not sex-specifically regulated in Musca domestica. Development 125: 1487-1494.
45. NAGOSHI, R. N., and B. S. BAKER, 1990 Regulation of sex-specific RNA splicing at the Drosophila doublesex gene: cis-acting mutations in exon sequences alter sex-specific RNA splicing patterns. Genes Dev. 4: 89-97.
46. NAGOSHI, R. N., M. MCKEOWN, K. C. BURTIS, J. M. BELOTE and B. S. BAKER, 1988 The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster. Cell 53: 229-236.
47. PIRROTTA, V., 1988 Vectors for P-mediated transformation in Drosophila, pp. 437-456 in Vectors: A Survey of Molecular Cloning Vectors and Their Uses, edited by R. L. RODRIQUEZ and D. T. DENHARDT. Butterworths, Boston.
48. RAYMOND, C. S., C. E. SHAMU, M. M. SHEN, K. J. SEIFERT, B. HIRSCH et al., 1998 Evidence for evolutionary conservation of sex-determining genes. Nature 391: 691-695.
49. RYNER, L. C., and B. S. BAKER, 1991 Regulation of doublesex pre-mRNA processing occurs by 3′-splice site activation. Genes Dev. 5: 2071-2085.
50. RYNER, L. C., S. F. GOODWIN, D. H. CASTRILLON, A. ANAND, A. VILLELLA et al., 1996 Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell 87: 1079-1089.
51. SCOTT, D., 1986 Sexual mimicry regulates the attractiveness of mated Drosophila melanogaster females. Proc. Natl. Acad. Sci. USA 83: 8429-8433.
52. SCOTT, D., 1996 Reply to: female mate discrimination or male responses to female stimulation? Evolution 50: 1720-1723.
53. TAYLOR, B. J., 1992 Differentiation of a male-specific muscle in Drosophila melanogaster does not require the sex-determining genes doublesex or intersex. Genetics 132: 179-191.
54. TAYLOR, B. J., and J. W. TRUMAN, 1992 Commitment of abdominal neuroblasts in Drosophila to a male or female fate is dependent on genes of the sex-determining hierarchy. Development 114: 625-642.
55. TAYLOR, B. J., A. VILLELLA, L. C. RYNER, B. S. BAKER and J. C. HALL, 1994 Behavioral and neurobiological implications of sex-determining factors in Drosophila. Dev. Genet. 15: 275-296.
56. TIAN, M., and T. MANIATIS, 1994 A splicing enhancer exhibits both constitutive and regulated activities. Genes Dev. 8: 1703-1712.
57. TOMPKINS, L., and S. P. MCROBERT, 1989 Regulation of behavioral and pheromonal aspects of sex determination in Drosophila melanogaster by the Sex-lethal gene. Genetics 123: 535-541.
58. VILLELLA, A., and J. C. HALL, 1996 Courtship anomalies caused by doublesex mutations in Drosophila melanogaster. Genetics 143: 331-344.
59. WILKINS, A. S., 1995 Moving up the hierarchy: a hypothesis on the evolution of a genetic sex determination pathway. Bioessays 17: 71-77.
60. ZHANG, S. D., and W. F. ODENWALD, 1995 Misexpression of the white (w) gene triggers male-male courtship in Drosophila. Proc. Natl. Acad. Sci. USA 92: 5525-5529.