Inhibition of NFκB-mediated pro-inflammatory gene expression in rat mesangial cells by the enolized 1,3-dioxane-4,6-dione-5-carboxamide, CGP-43182

British Journal of Pharmacology

Volumn 130, Issue 5, 2000, Pages 1183-1190

  Scholz Pedretti, Kirsten ^a   Eberhardt, Wolfgang ^a   Rupprecht, Gerhard ^a   Beck, Karl Friedrich ^a   Spitzer, Silke ^a   Pfeilschifter, Josef ^a   Kaszkin, Marietta ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Cyclic AMP; Cyclo oxygenase; Inducible nitric oxide synthase; Interleukin 1 ; I B; Mesangial cells; NF B; Secretory; Transcription factors

Indexed keywords

1,3 DIOXANE DERIVATIVE; ARACHIDONIC ACID; BUCLADESINE; CGP 43182; CYCLOOXYGENASE 2; ICOSANOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PROSTAGLANDIN E2; UNCLASSIFIED DRUG; CHLOROBENZENE; DNA BINDING PROTEIN; ENZYME INHIBITOR; I KAPPA B; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; ISOENZYME; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; NOS2 PROTEIN, RAT; PHOSPHOLIPASE A; PROSTACYCLIN; PROSTAGLANDIN SYNTHASE;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; ENZYME INDUCTION; ENZYME INHIBITION; GENE EXPRESSION REGULATION; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; MESANGIUM; METABOLISM; PHYSIOLOGY;

ANIMALS; CHLOROBENZENES; CYCLOOXYGENASE 2; DNA-BINDING PROTEINS; ENZYME INHIBITORS; EPOPROSTENOL; GENE EXPRESSION REGULATION; GLOMERULAR MESANGIUM; I-KAPPA B PROTEINS; INTERLEUKIN-1; ISOENZYMES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHOLIPASES A; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS;

EID: 0033624039     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703419     Document Type: Article

References (45)

1. BAEUERLE, P. (1998). IκB-NF-κB structures: at the interface of inflammation control. Cell, 95, 729-731.
2. BAEUERLE, P. & HENKEL, T. (1994). Function and activation of NF-κB in the immune system. Ann. Rev. Immunol., 12, 141-179.
3. BARNES, P.J. & KARIN, M. (1997). Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med., 336, 1066-1071.
4. BECK, K.F. & STERZEL, R.B. (1996). Cloning and sequencing of the proximal promoter of the rat iNOS gene: activation of NFκB is not sufficient for transcription of the iNOS gene in rat mesangial cells. FEBS Lett., 394, 263-267.
5. 2: enolizrd 1,3-dioxane-4,6-dione-5-carboxamides. Eur. J. Med. Chem., 29, 649-658.
6. BROWN, K., GERSTBERGER, S., CARLSON, L., FRANZOSO, G. & SIEBENLIST, U. (1995). Control of IκB-alpha proteolysis by site-specific, signal-induced phosphorylation. Science, 267, 1485-1488.
7. EBERHARDT, W., KUNZ, D. & PFEILSCHIFTER, J. (1994). Pyrrolidine dithiocarbamate differentially affects interleukin Iβ-and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells. Biochem. Biophys. Res. Commun., 200, 163-170.
8. EBERHARDT, W., PLÜSS, C., HUMMEL, R. & PFEILSCHIFTER, J. (1998). Molecular mechanisms of inducible nitric oxide synthase gene expression by IL-1β and cAMP in rat mesangial cells. J. Immunol., 160, 4961-4969.
9. 2 activity is raised in the uninvolved epidermis of psoriasis. Br. J. Dermatol., 108, 103-105.
10. GONZALEZ, G.A. & MONTMINY, M.R. (1989). Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell, 59, 675-680.
11. 2 activity associated with sepsis and septic shock is indistinguishable from that associated with rheumatoid arthritis. Inflammation, 15, 355-367.
12. 15N]nitrate in biological fluids. Anal. Biochem., 126, 131-138.
13. 2 in serum and pulmonary and renal complications in acute pancreatitis. Digestion, 52, 232-236.
14. 2 in rat renal mesangial cells. Biochim. Biophys. Acta. 1348, 257-272.
15. 2 antigen in arthritic synovium. Ann. Rheum. Dis., 57, 550-558.
16. 2 messenger RNA and protein in colorectal adenomas from familial adenomatous polyposis patients. Cancer Res., 58, 500-503.
17. KLEIN, T., NUSING, R.M., PFEILSCHIFTER, J. & ULLRICH, V. (1994). Selective inhibition of cyclooxygenase 2. Biochem. Pharmacol., 48, 1605-1610.
18. KUNZ, D., MÜHL, H., WALKER, G. & PFEILSCHIFTER, J. (1994). Two distinct signaling pathways trigger the expression of inducible nitric oxide synthase in rat renal mesangial cells. Proc. Natl. Acad. Sci. U.S.A., 91, 5387-5391.
19. LAEMMLI, U.K. (1970). Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature, 227, 680-685.
20. 2 in human polymorphonuclear leukocytes. Biochim. Biophys. Acta, 879, 149-156.
21. MARTIN, M., NEUMANN, D., HOFF, T., RESCH, K., DEWITT, D.L. & GOPPELT-STRUEBE, M. (1994). Interleukin-1-induced cyclooxygenase 2 expression is suppressed by cyclosporin A in rat mesangial cells. Kidney Int., 45, 150-158.
22. MERCURIO, F. & MANNING, A.M (1999). NFκB as a primary regulator of the stress response. Oncogene, 18, 6163-6171.
23. 2 gene expression by interleukin-1 and forskolin in rat mesangial cells. FEBS Lett., 301, 190-194.
24. 2 on the induction of nitric oxide- and prostanoid-forming pathways in cultured rat mesangial cells. Biochem. J., 313, 617-623.
25. PFEILSCHIFTER, J. (1994). Mesangial cells orchestrate inflammation in the renal glomerulus. News Physiol. Sci., 9, 271-276.
26. 2 in Clinical Inflammation. ed. Glaser, K.B., Vadas, P. pp 25-51. New York: CRC Press.
27. PFEILSCHIFTER, J. & MÜHL, H (1999). Immunopharmacology: anti-inflammatory therapy targeting transcription factors. Eur. J. Pharmacol., 375: 237-245.
28. PFEILSCHIFTER, J & SCHWARZENBACH, H. (1990). Interleukin 1 and tumor necrosis factor stimulate cGMP formation in rat renal mesangial cells. FEBS Lett., 273, 185-187.
29. PFEILSCHIFTER, J., KURTZ, A. & BAUER, C. (1984). Activation of phospholipase C and prostaglandin synthesis by [arginine]vasopressin in cultures of rat renal mesangial cells. Biochem. J., 223, 855-859.
30. 2 secretion from rat renal mesangial cells. Biochem. J., 273, 199-204.
31. 2 by rat mesangial cells. J. Clin. Invest., 92, 2516-2523.
32. 2, basic and clinical aspects in inflammatory diseases. Prog. Surg., 24, 31-37.
33. 2: preferential hydrolysis of acute phase HDL. J. Lipid Res., 39, 2150-2160.
34. RAY, B.K. & RAY, A. (1994). Expression of the gene encoding χ1-acid glycoprotein in rabbit liver under acute-phase conditions involves induction and activation of β and δ CAAT-enhancer-binding proteins. Eur. J. Biochem., 222, 891-900.
35. 2 and inducible NO-synthase in rat renal mesangial cells. Br. J. Pharmacol., 127, 51-56.
36. SALVEMINI, D. (1997). Regulation of cyclooxygenase enzymes by nitric oxide. Cell. Mol. Life Sci., 53, 576-582.
37. SAMBROOK, J., FROTSCJ, J. & MANIATIS, T. (1989). Molecular cloning: a Laboratory Manual. New York: Cold Spring Harbor Laboratory Press.
38. 2. J. Biol. Chem., 267, 8846-8851.
39. SCHREIBER, E., MATTHIAS, P., MÜLLER, M.M. & SCHAFFNER, W. (1989). Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res., 17, 6419.
40. 2 in healthy humans and in active Crohn's disease. Scand. J. Gastroenterol., 33, 1094-1098.
41. 2 mRNA and activity levels in interleukin 1β-and forskolin-stimulated mesangial cells. Biochem. J., 315, 435-441.
42. 2 as an autocrine growth factor mediating interleukin-1 action on mesangial cells. Biochim. Biophys. Acta, 1345, 99-108.
43. 2 expression in rat renal mesangial cells. Biochim. Biophys. Acta, 1391, 213-222.
44. 2 in rat renal mesangial cells. FEBS Lett., 364, 218-222.
45. 2 in rat renal mesangial cells. Br. J. Pharmacol., 121, 787-793.