Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective β3 adrenergic receptor agonist antiobesity agents

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 13, 2000, Pages 1431-1434

  Biftu, Tesfaye ^a   Feng, Dennis D ^a   Liang, Gui Bai ^a   Kuo, Howard ^a   Qian, Xiaoxia ^a   Naylor, Elizabeth M ^a   Colandrea, Vincent J ^a   Candelore, Mari R ^a   Cascieri, Margaret A ^a   Colwell, Lawrence F ^a   Forrest, Michael J ^a   Hom, Gary J ^a   MacIntyre, D Euan ^a   Stearns, Ralph A ^a   Strader, Catherine D ^a   Wyvratt, Matthew J ^a   Fisher, Michael H ^a   Weber, Ann E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 BENZYL OXADIAZOLE DERIVATIVE; ANTIOBESITY AGENT; BENZENESULFONAMIDE DERIVATIVE; BETA 3 ADRENERGIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DOG; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG SYNTHESIS; NONHUMAN; OBESITY; RHESUS MONKEY; STRUCTURE ACTIVITY RELATION;

ADRENERGIC BETA-AGONISTS; ANIMALS; ANTI-OBESITY AGENTS; BIOLOGICAL AVAILABILITY; CHO CELLS; CRICETINAE; DOGS; DRUG DESIGN; GLYCEROL; HEART RATE; HUMANS; MACACA MULATTA; OXADIAZOLES; RECEPTORS, ADRENERGIC, BETA-3; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

ANIMALIA; CANIS FAMILIARIS; MACACA MULATTA;

EID: 0034601158     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00268-7     Document Type: Article

References (6)

1. Feng D.D., Biftu T., Liang G.-B., Kuo H., Qian X., Naylor E.M., Colandrea V.J., Candelore M.R., Cascieri M.A., Colwell L.F. Jr., Forrest M.J., Hom G.J., MacIntyre D.E., Stearns R.A., Wyvratt M.J., Fisher M.H., Weber A.E. Bioorg. Med. Chem. Lett. 10:2000;1427.
2. For experimental detail see Biftu, T.; Feng, D.; Fisher, M. H.; Kuo, K.; Liang, G.-B.; Weber, A. E. Patent Application WO 09746556 A1, 1997; Chem. Abstr. 1998, 128, 75405f.
3. For experimental detail see Biftu, T.; Feng, D.; Fisher, M. H.; Kuo, K.; Liang, G.-B.; Weber, A. E. Patent Application WO 09746556 A1, 1997; Chem. Abstr. 1998, 128, 75405f.
4. Liang G.-B., Feng D.D. Tetrahedron Lett. 37:1996;6627.
5. Boualem, O.; Moeini, L.; Benoit, M.; Villemin, D.; Garrigues, B. Synth. Comm. 1995, 1451.
6. All new compounds were characterized by NMR and mass spectrometry.